INT99071

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Context Info
Confidence 0.55
First Reported 2001
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 9.87
Pain Relevance 7.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)
Anatomy Link Frequency
neurons 4
hepatocytes 2
nerves 2
DRG 2
Mapk8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 227 100.00 Very High Very High Very High
Spinal nerve ligature 7 99.98 Very High Very High Very High
Kinase C 43 99.68 Very High Very High Very High
Morphine 21 99.28 Very High Very High Very High
dorsal root ganglion 20 99.20 Very High Very High Very High
ischemia 45 99.12 Very High Very High Very High
tolerance 12 97.92 Very High Very High Very High
substance P 12 97.08 Very High Very High Very High
Thalamus 3 95.96 Very High Very High Very High
Sciatic nerve 26 94.80 High High
Disease Link Frequency Relevance Heat
Stress 173 99.84 Very High Very High Very High
Sepsis 63 99.22 Very High Very High Very High
Ganglion Cysts 39 99.20 Very High Very High Very High
Cv Unclassified Under Development 38 99.12 Very High Very High Very High
Death 151 98.68 Very High Very High Very High
Urological Neuroanatomy 5 96.28 Very High Very High Very High
Hypoxia 55 96.08 Very High Very High Very High
Apoptosis 183 95.48 Very High Very High Very High
Injury 61 95.44 Very High Very High Very High
Obesity 20 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we found that preemptive edaravone treatment can reduce the SNL-induced pJNK expression in the ipsilateral DRG.
Positive_regulation (induced) of Gene_expression (expression) of pJNK in DRG associated with dorsal root ganglion and spinal nerve ligature
1) Confidence 0.55 Published 2009 Journal Brain Res. Section Abstract Doc Link 19028459 Disease Relevance 1.44 Pain Relevance 1.84
Sepsis induced an increase in the expression/activation of TLR4 and its downstream signaling JNK and IKK/NF-?
Positive_regulation (activation) of Gene_expression (signaling) of JNK associated with sepsis
2) Confidence 0.35 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2997789 Disease Relevance 0.72 Pain Relevance 0.20
The results showed that danshen increased the expressions of uPA, cyclin D1, E and ERK, JNK, and P38 MAP kinases via the FGF-2 signaling pathway in a dose-dependent manner.
Positive_regulation (increased) of Gene_expression (expressions) of JNK
3) Confidence 0.33 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2997511 Disease Relevance 0 Pain Relevance 0.05
Roth and colleagues (2003) reported that JNK expression was significantly increased within 6 hours after ischemia-reperfusion.
Positive_regulation (increased) of Gene_expression (expression) of JNK associated with ischemia
4) Confidence 0.33 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.59 Pain Relevance 0.05
JNK expression as well as ASK1 and SEK1/MEK4 expression in the GCL was significantly increased only at the initial phase after reperfusion.
Positive_regulation (increased) of Gene_expression (expression) of JNK
5) Confidence 0.33 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.67 Pain Relevance 0.04
To identify the role of MAPK signaling in danshen-induced nerve cell proliferation, we examined the MAPK signaling activities in regenerated nerves and found that the levels of phosphorylated ERK, JNK, and P38 were increased (Figure 1(b)).
Positive_regulation (increased) of Gene_expression (levels) of JNK in nerves
6) Confidence 0.31 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0 Pain Relevance 0.04
Total expression of the three MAPKs (JNK, ERK, and p38) and ?
Positive_regulation (Total) of Gene_expression (expression) of JNK
7) Confidence 0.27 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2089075 Disease Relevance 1.08 Pain Relevance 0
in As-induced JNK activation.
Positive_regulation (induced) of Gene_expression (activation) of JNK
8) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.30 Pain Relevance 0.65
Pre-exposure of hepatocytes to a JNK inhibitor SP600125 prevented As-induced caspase-3 activation, ROS production and loss in cell viability.
Positive_regulation (activation) of Gene_expression (exposure) of JNK in hepatocytes
9) Confidence 0.25 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935368 Disease Relevance 1.01 Pain Relevance 0
Distinct PKC-activated MAPK pathways, including p38MAPK, ERK1/2 and JNK, were investigated in chronic oxaliplatin rat.
Spec (investigated) Positive_regulation (activated) of Spec (investigated) Gene_expression (pathways) of JNK
10) Confidence 0.23 Published 2009 Journal Pain Section Abstract Doc Link 19683395 Disease Relevance 0.88 Pain Relevance 0.64
Repeated morphine exposure (10-20 microm) for 6 days increased the number of neurons expressing phosphorylated (p) mitogen-activated protein (MAP) kinases, including the extracellular signal-regulated kinase (pERK), c-jun N-terminal kinase (pJNK) and P38 (pP38 MAPK).
Positive_regulation (increased) of Gene_expression (expressing) of pJNK in neurons associated with morphine
11) Confidence 0.19 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11683901 Disease Relevance 0.85 Pain Relevance 1.61
Repeated morphine exposure (10-20 microm) for 6 days increased the number of neurons expressing phosphorylated (p) mitogen-activated protein (MAP) kinases, including the extracellular signal-regulated kinase (pERK), c-jun N-terminal kinase (pJNK) and P38 (pP38 MAPK).
Positive_regulation (increased) of Gene_expression (expressing) of c-jun N-terminal kinase in neurons associated with morphine
12) Confidence 0.19 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11683901 Disease Relevance 0.84 Pain Relevance 1.61
Moreover, the MEK/ERK pathway, but not JNK or p38 MAPK, is required for NOS I mRNA or protein expression and activity in PC12 cells [18].
Positive_regulation (required) of Gene_expression (expression) of JNK
13) Confidence 0.18 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.48 Pain Relevance 0.19
Interestingly, Liu et al. [38] reported that restraint, like swim, elevated both P-MKK4 and P-JNK levels in mice, but the effects in the former stress model were smaller than in the latter.
Positive_regulation (elevated) of Gene_expression (levels) of P-JNK associated with stress
14) Confidence 0.17 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.67 Pain Relevance 0.09
Dopamine and NMDA stimulation converge on ERK2 but not p38 nor JNK
Neg (not) Positive_regulation (not) of Gene_expression (Dopamine) of JNK associated with dopamine
15) Confidence 0.06 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762427 Disease Relevance 0 Pain Relevance 0.28
Dopamine and NMDA stimulation converge on ERK2 but not p38 nor JNK
Neg (nor) Positive_regulation (on) of Gene_expression (Dopamine) of JNK associated with dopamine
16) Confidence 0.06 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762427 Disease Relevance 0 Pain Relevance 0.28
Stress signal-induced ATF3 expression, via JNK and
               p53 pathways, has been shown in various types of cells [46], [47]. 
Positive_regulation (induced) of Gene_expression (expression) of JNK associated with stress
17) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771921 Disease Relevance 0.34 Pain Relevance 0

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