INT99076

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Context Info
Confidence 0.62
First Reported 2001
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 1.34
Pain Relevance 7.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (FosB) DNA binding (FosB)
Anatomy Link Frequency
nucleus accumbens 2
brain 2
nucleus 2
FosB (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 1 100.00 Very High Very High Very High
Ventral tegmentum 4 99.98 Very High Very High Very High
Nucleus accumbens 14 99.68 Very High Very High Very High
psychological dependence 2 99.66 Very High Very High Very High
Morphine 54 99.00 Very High Very High Very High
Abstinence syndrome 1 98.80 Very High Very High Very High
narcan 7 98.54 Very High Very High Very High
withdrawal 13 97.52 Very High Very High Very High
addiction 8 96.80 Very High Very High Very High
Glutamate receptor 2 94.04 High High
Disease Link Frequency Relevance Heat
Recurrence 1 99.92 Very High Very High Very High
Drug Dependence 4 99.66 Very High Very High Very High
Disease 3 98.80 Very High Very High Very High
Syndrome 1 98.36 Very High Very High Very High
Stress 4 98.00 Very High Very High Very High
Morphine Dependence 3 97.16 Very High Very High Very High
Parkinson's Disease 1 91.52 High High
Weight Loss 2 75.40 Quite High
Dyskinesias 1 74.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We studied the effects of osmotic stimulation on the expression of FosB and c-Fos in the supraoptic nucleus (SON) and paraventricular nucleus (PVN).
Regulation (effects) of Gene_expression (expression) of FosB in nucleus
1) Confidence 0.62 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15899256 Disease Relevance 0 Pain Relevance 0.09
This study investigates the effects of time postdenervation and L-dopa treatment duration on the striatal expression of opioid precursor mRNAs and FosB/DeltaFosB-related proteins.
Spec (investigates) Regulation (effects) of Gene_expression (expression) of FosB associated with opioid
2) Confidence 0.58 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11683909 Disease Relevance 0.34 Pain Relevance 0.14
All these results suggest that agmatine could inhibit morphine-induced psychological dependence and relapses by affecting the expression of transcription factor FosB.
Regulation (affecting) of Gene_expression (expression) of FosB associated with psychological dependence, recurrence and morphine
3) Confidence 0.56 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15899480 Disease Relevance 0.33 Pain Relevance 0.83
Moreover, altered innate expression of FosB/DeltaFosB and pCREB in AA rats is likely to affect the sensitivity of these rats to abused drugs.
Regulation (altered) of Gene_expression (expression) of FosB
4) Confidence 0.44 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19324071 Disease Relevance 0 Pain Relevance 1.00
Moreover, altered innate expression of FosB/DeltaFosB and pCREB in AA rats is likely to affect the sensitivity of these rats to abused drugs.
Regulation (altered) of Gene_expression (expression) of DeltaFosB
5) Confidence 0.37 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19324071 Disease Relevance 0 Pain Relevance 1.00
Ionotropic glutamatergic neurotransmission in the ventral tegmental area modulates DeltaFosB expression in the nucleus accumbens and abstinence syndrome in morphine withdrawal rats.
Regulation (modulates) of Gene_expression (expression) of DeltaFosB in nucleus accumbens associated with nucleus accumbens, ventral tegmentum, syndrome, narcan, withdrawal, morphine and abstinence syndrome
6) Confidence 0.21 Published 2005 Journal Eur. J. Pharmacol. Section Title Doc Link 16303124 Disease Relevance 0.26 Pain Relevance 1.44
This study was designed to evaluate the possible modifications in FosB/DeltaFosB expression in both hypothalamic and extrahypothalamic brain stress system during morphine dependence and withdrawal.
Spec (possible) Regulation (modifications) of Gene_expression (expression) of FosB/DeltaFosB in brain associated with stress, addiction, withdrawal and morphine
7) Confidence 0.20 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20438612 Disease Relevance 0.41 Pain Relevance 0.88
Moreover, altered innate expression of FosB/DeltaFosB and pCREB in AA rats is likely to affect the sensitivity of these rats to abused drugs.
Spec (likely) Regulation (affect) of Gene_expression (expression) of DeltaFosB
8) Confidence 0.16 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19324071 Disease Relevance 0 Pain Relevance 0.97
Moreover, altered innate expression of FosB/DeltaFosB and pCREB in AA rats is likely to affect the sensitivity of these rats to abused drugs.
Regulation (sensitivity) of Gene_expression (expression) of DeltaFosB
9) Confidence 0.16 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19324071 Disease Relevance 0 Pain Relevance 0.97

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