INT99077

Context Info Confidence 0.50 First Reported 2001 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.04 Pain Relevance 1.67

nucleus (FosB) DNA binding (FosB)

FosB (Rattus norvegicus)

Pain Link Frequency Relevance Heat cocaine 14 99.20 antagonist 12 95.56 Cannabinoid receptor 3 92.12 withdrawal 15 91.24 Morphine 9 91.12 agonist 4 88.40 Cannabinoid 7 88.08 cannabis 3 81.76 Serotonin 4 78.12 Opioid 13 75.76

Disease Link Frequency Relevance Heat Recurrence 5 96.80 Dyskinesias 1 89.76 Targeted Disruption 6 84.04 Cannabis Dependence 1 83.36 Disease 5 75.00 Cocaine Dependence 1 63.92 Parkinson's Disease 1 63.36 Drug Dependence 15 50.00 Opiate Addiction 8 24.40 Alcohol Addiction 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

L-DOPA, but not bromocriptine, induced high striatal levels of FosB/DeltaFosB immunoreactivity and prodynorphin mRNA, and these did not differ between short-term and long-term L-DOPA-treated rats.

Transcription (levels) of FosB

1) Confidence 0.50 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11683909 Disease Relevance 0.30 Pain Relevance 0.10

Effect on transcription factor FosB

Transcription (transcription factor) of FosB

2) Confidence 0.18 Published 2007 Journal Indian Journal of Psychiatry Section Body Doc Link PMC2917090 Disease Relevance 0.74 Pain Relevance 1.56

General Comments

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