INT9908

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 1987
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 29
Total Number 30
Disease Relevance 19.37
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IAPP) extracellular region (IAPP) cell-cell signaling (IAPP)
Anatomy Link Frequency
abdomen 4
tube 1
blood 1
muscle 1
superior 1
IAPP (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 4 99.22 Very High Very High Very High
Snapping jaw 5 96.12 Very High Very High Very High
agonist 29 94.24 High High
palliative 2 90.56 High High
anesthesia 15 84.60 Quite High
Neuropeptide 5 81.04 Quite High
Angina 10 75.00 Quite High
noradrenaline 9 73.28 Quite High
Dopamine 5 71.84 Quite High
Nucleus accumbens 3 70.00 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 229 100.00 Very High Very High Very High
Diabetes Mellitus 147 100.00 Very High Very High Very High
Pressure And Volume Under Development 90 99.62 Very High Very High Very High
Hypertension 85 98.68 Very High Very High Very High
Hepatocellular Cancer 4 98.16 Very High Very High Very High
Breast Cancer 91 97.84 Very High Very High Very High
Pancreatic Cancer 37 97.36 Very High Very High Very High
Cancer 344 97.24 Very High Very High Very High
Necrosis 16 97.00 Very High Very High Very High
Fistula 12 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Individual groups analysis showed significative reductions of SAP, DAP and HR in propranolol group.
Negative_regulation (reductions) of DAP
1) Confidence 0.57 Published 1992 Journal Arq. Bras. Cardiol. Section Body Doc Link 1444872 Disease Relevance 0.07 Pain Relevance 0
The apoptosis induced by PTX-2 in Hep3B cells was associated with the down-regulation of anti-apoptotic Bcl-2 members (Bcl-2 and Bcl-xL) and IAP family proteins, the up-regulation of pro-apoptotic Bax protein and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-receptor 1/receptor 2 (DR4/DR5) and mitochondrial dysfunction.
Negative_regulation (down-regulation) of IAP associated with parkinson's disease, necrosis, cancer and apoptosis
2) Confidence 0.57 Published 2008 Journal Oncol. Rep. Section Abstract Doc Link 18202802 Disease Relevance 1.69 Pain Relevance 0.12
Insufficient decrease in SAP and DAP at nighttime was detected.
Negative_regulation (decrease) of DAP
3) Confidence 0.57 Published 2008 Journal Klin Med (Mosk) Section Abstract Doc Link 19048842 Disease Relevance 0.35 Pain Relevance 0.14
During clenching without the IOA, pressures ranged from 20 to 200 mm Hg (mean, 68.8 +/- 49.1), decreasing by 81.2% to IAP levels ranging from 0 to 40 mm Hg (mean, 7.9 +/- 10.9; P < .001) with the appliance in place.
Negative_regulation (decreasing) of IAP
4) Confidence 0.43 Published 1994 Journal J. Oral Maxillofac. Surg. Section Abstract Doc Link 8006730 Disease Relevance 0.36 Pain Relevance 0.51
We hypothesized that increased IAP decreases during PEEP release, and that this effect is more pronounced in the upper abdomen and intra-vascularly.


Negative_regulation (decreases) of IAP in abdomen
5) Confidence 0.42 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912801 Disease Relevance 0.07 Pain Relevance 0.13
In all four groups a slight decrease in HR and SVR occurred while a marked decrease in arterial blood pressure (SAP, MAP, DAP) and cardiac output was seen.
Negative_regulation (decrease) of DAP in blood
6) Confidence 0.42 Published 1987 Journal Anaesthesist Section Abstract Doc Link 2892430 Disease Relevance 0.09 Pain Relevance 0.28
Degree of SAP and DAP nighttime decrease initially was upon the average 8.1 +/- 1.1% and 7.0 +/- 1.0% respectively (non-dippers), and after combined treatment was 13.4 +/- 0.9% (p = 0.003) and 11.0 +/- 1.1% (dippers), which proved recovery of normal daily AP profile.
Negative_regulation (decrease) of DAP
7) Confidence 0.42 Published 2008 Journal Klin Med (Mosk) Section Abstract Doc Link 19048842 Disease Relevance 0.31 Pain Relevance 0.13
SAP and DAP variability was significantly decreased only at daytime from 23.1 +/- 1.7 to 18.8 +/- 1.4 (p = 0.05) and from 18.1 +/- 0.5 to 16.5 +/- 0.4 respectively.
Negative_regulation (decreased) of DAP
8) Confidence 0.42 Published 2008 Journal Klin Med (Mosk) Section Abstract Doc Link 19048842 Disease Relevance 0.37 Pain Relevance 0.15
Increases in IAP are also associated with increased respiratory pressures, and decreased lung compliance and gas exchange [41,42].
Negative_regulation (decreased) of IAP in lung
9) Confidence 0.41 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912801 Disease Relevance 0.31 Pain Relevance 0
Inclusion of melatonin in traditional therapy leaded to more expressed decrease in average daily, daytime and nighttime AP indices and significant decrease in load by pressure value (SAP and DAP time indices were significantly reduced both at daytime and at nighttime).
Negative_regulation (reduced) of DAP
10) Confidence 0.41 Published 2008 Journal Klin Med (Mosk) Section Abstract Doc Link 19048842 Disease Relevance 0.32 Pain Relevance 0.13
In addition, IND also down-regulated anti-apoptotic genes of the IAP family.
Negative_regulation (down-regulated) of IAP
11) Confidence 0.41 Published 2006 Journal World J. Gastroenterol. Section Body Doc Link 17072976 Disease Relevance 0.21 Pain Relevance 0
The subcutaneous approach eliminates the open abdomen, but might not be effective enough, as suggested by our own experience in 7 patients so far, where the decrease of IAP was sufficient in 4 patients.
Negative_regulation (decrease) of IAP in abdomen
12) Confidence 0.39 Published 2008 Journal World J Emerg Surg Section Body Doc Link PMC2266717 Disease Relevance 0.79 Pain Relevance 0
Although percutaneous drainage of ascites can in some cases decrease IAP at least temporarily, surgical decompression, most commonly performed through a long vertical midline incision leaving the abdomen open and covered with a negative abdominal pressure dressing, is the preferred method of treatment [8].
Negative_regulation (decrease) of IAP in abdomen associated with pressure and volume under development
13) Confidence 0.39 Published 2008 Journal World J Emerg Surg Section Body Doc Link PMC2266717 Disease Relevance 0.97 Pain Relevance 0
It has been shown that bolus administration of opioids and muscle relaxants can increase and decrease, respectively, IAP [47,48].
Negative_regulation (decrease) of IAP in muscle associated with opioid
14) Confidence 0.36 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912801 Disease Relevance 0.05 Pain Relevance 0.10
A reduction of IAP may also improve renal perfusion by lowering venous and retroperitoneal pressure.
Negative_regulation (reduction) of IAP
15) Confidence 0.34 Published 2008 Journal Crit Care Section Body Doc Link PMC2374626 Disease Relevance 0.12 Pain Relevance 0
Midline decompressive laparostomy is effective in decreasing IAP, rapid and easy to perform, but it is associated with a high risk of intestinal fistulas (about 5% in trauma patients with open abdomen) [10], and in many cases failure to close the fascia requiring complex reconstructive surgery 9–12 months later [16].
Negative_regulation (decreasing) of IAP in abdomen associated with fistula and injury
16) Confidence 0.34 Published 2008 Journal World J Emerg Surg Section Body Doc Link PMC2266717 Disease Relevance 0.88 Pain Relevance 0
The decrease in IAP was correlated with the relative change in SVRI after paracentesis (r = 0.586, P = 0.007).
Negative_regulation (decrease) of IAP
17) Confidence 0.30 Published 2008 Journal Crit Care Section Body Doc Link PMC2374626 Disease Relevance 0.30 Pain Relevance 0
Improved glycemic control reduces the risk of microvascular complications and macrovascular events in type 2 diabetes [12,13].
Negative_regulation (reduces) of diabetes associated with diabetes mellitus
18) Confidence 0.26 Published 2008 Journal Osteopath Med Prim Care Section Body Doc Link PMC2276216 Disease Relevance 1.15 Pain Relevance 0
After paracentesis there was a marked decrease in IAP and RPP.
Negative_regulation (decrease) of IAP
19) Confidence 0.25 Published 2008 Journal Crit Care Section Body Doc Link PMC2374626 Disease Relevance 0.77 Pain Relevance 0
During paracentesis, IAP decreased from 22 mmHg (18 to 24) to 9 mmHg (8 to 12).
Negative_regulation (decreased) of IAP
20) Confidence 0.22 Published 2008 Journal Crit Care Section Abstract Doc Link PMC2374626 Disease Relevance 1.15 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox