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Context Info
Confidence 0.15
First Reported 2001
Last Reported 2002
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.87
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdyn) lyase activity (Ddc) plasma membrane (Pdyn)
intracellular (Ddc) cellular amino acid metabolic process (Ddc) cytoplasm (Ddc)
Ddc (Rattus norvegicus)
Pdyn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 1 77.88 Quite High
Dopamine 2 66.32 Quite High
Enkephalin 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Dyskinesias 7 91.88 High High
Disease 5 75.00 Quite High
Parkinson's Disease 1 65.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
L-DOPA, but not bromocriptine, induced high striatal levels of FosB/DeltaFosB immunoreactivity and prodynorphin mRNA, and these did not differ between short-term and long-term L-DOPA-treated rats.
L-DOPA Neg (not) Positive_regulation (induced) of prodynorphin
1) Confidence 0.15 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11683909 Disease Relevance 0.31 Pain Relevance 0.11
Both AIM development and the associated upregulation of prodynorphin mRNA by L-DOPA are significantly inhibited by the intrastriatal infusion of fosB antisense.
L-DOPA Positive_regulation (upregulation) of prodynorphin
2) Confidence 0.14 Published 2002 Journal Amino Acids Section Abstract Doc Link 12373525 Disease Relevance 0.56 Pain Relevance 0.03

General Comments

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