INT99090

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Context Info
Confidence 0.55
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.33
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Hgf) extracellular space (Hgf) cell morphogenesis (Hgf)
Anatomy Link Frequency
bladder 2
liver 1
PGE2 1
Hgf (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 3 99.42 Very High Very High Very High
Antinociceptive 1 94.32 High High
antagonist 7 92.16 High High
Inflammatory response 1 90.08 High High
Spinal cord 2 79.84 Quite High
Inflammation 1 75.00 Quite High
cytokine 2 73.84 Quite High
substance P 1 72.16 Quite High
qutenza 4 65.96 Quite High
Calcitonin gene-related peptide 3 56.44 Quite High
Disease Link Frequency Relevance Heat
Nociception 2 99.88 Very High Very High Very High
Pressure And Volume Under Development 10 98.52 Very High Very High Very High
Overflow Incontinence 1 97.52 Very High Very High Very High
Cystitis 2 96.72 Very High Very High Very High
Overactive Bladder 1 96.48 Very High Very High Very High
Necrosis 2 84.12 Quite High
Cancer 2 83.76 Quite High
INFLAMMATION 2 75.00 Quite High
Hyperplasia 1 61.04 Quite High
Targeted Disruption 12 54.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Due to the multitude of HGF/c-Met functions, including regulation of mitogenesis, motogenesis, and morphogenesis, HGF signaling is considered to be a primary stimulator of liver regeneration.
Regulation (regulation) of HGF in liver
1) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.28 Pain Relevance 0.04
These findings suggest an involvement of tachykinins and NK2 receptors in the response to chemical irritation of the LUT in mice and also suggest that tachykinins contribute to the regulation of normal reflex bladder activity.
Regulation (involvement) of NK2 in bladder
2) Confidence 0.44 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11684339 Disease Relevance 0.19 Pain Relevance 0.26
This study examined the contribution of vanilloid-1 (TRPV1), peripheral NK1 receptors to CPM-evoked nociceptive behaviors and bladder edema, and its possible modulation by alpha, beta-amyrin.
Spec (examined) Regulation (contribution) of NK1 in bladder associated with nociception and pressure and volume under development
3) Confidence 0.44 Published 2007 Journal Inflamm. Res. Section Abstract Doc Link 18210232 Disease Relevance 0.52 Pain Relevance 0.08
Collectively, these findings indicate that edematogenic responses elicited by PGE2 are mediated by EP3 receptor activation, also involving the stimulation of PLC, PKC, and MAPKs pathways and the participation of TRPV1 and NK1 receptors.
Regulation (participation) of NK1 in PGE2 associated with kinase c
4) Confidence 0.12 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16644903 Disease Relevance 0.33 Pain Relevance 0.38

General Comments

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