INT99091

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2001
Last Reported 2010
Negated 6
Speculated 5
Reported most in Body
Documents 70
Total Number 76
Disease Relevance 31.68
Pain Relevance 5.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (AR) transport (AR) enzyme binding (AR)
DNA binding (AR) cell-cell signaling (AR) cytoplasm (AR)
Anatomy Link Frequency
brain 2
kidney 2
22RV1 2
MDA-kb2 2
embryos 1
AR (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 181 100.00 Very High Very High Very High
Acupuncture 110 99.64 Very High Very High Very High
agonist 275 99.56 Very High Very High Very High
Pain 53 99.20 Very High Very High Very High
Cannabinoid receptor 5 99.20 Very High Very High Very High
adenocard 146 98.94 Very High Very High Very High
Inflammation 77 96.16 Very High Very High Very High
Rostral ventromedial medulla 51 95.76 Very High Very High Very High
Central grey 93 95.60 Very High Very High Very High
Endocannabinoid 5 94.40 High High
Disease Link Frequency Relevance Heat
Rhinitis 112 100.00 Very High Very High Very High
Prostate Cancer 1298 99.84 Very High Very High Very High
Reprotox - General 1 565 99.76 Very High Very High Very High
Carcinoma 26 99.60 Very High Very High Very High
Alopecia 143 99.48 Very High Very High Very High
Cancer 1310 99.44 Very High Very High Very High
Hypersensitivity 75 99.26 Very High Very High Very High
Pain 60 99.20 Very High Very High Very High
Disease 202 99.12 Very High Very High Very High
Chronic Sinusitis 14 98.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of essential oils, such as raspberry ketone, on androgen (AR) receptor was investigated using a MDA-kb2 human breast cancer cell line for predicting potential AR activity.
Spec (investigated) Regulation (effect) of androgen in MDA-kb2 associated with breast cancer
1) Confidence 0.45 Published 2010 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 20226658 Disease Relevance 0.18 Pain Relevance 0.11
It is worth noting how few AR target genes are deregulated in PC346Flu1 versus the parental PC346C (Fig. 2).
Regulation (deregulated) of AR
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0 Pain Relevance 0.04
AR location analysis discloses ligand-independent, AR-dependent gene regulation
Neg (independent) Regulation (regulation) of AR-dependent
3) Confidence 0.45 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 0 Pain Relevance 0
E2 was the only steroid tested that altered AR mRNA and protein levels.
Regulation (altered) of AR mRNA
4) Confidence 0.40 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1192819 Disease Relevance 0.13 Pain Relevance 0
The effect of essential oils, such as raspberry ketone, on androgen (AR) receptor was investigated using a MDA-kb2 human breast cancer cell line for predicting potential AR activity.
Spec (investigated) Regulation (effect) of AR in MDA-kb2 associated with breast cancer
5) Confidence 0.40 Published 2010 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 20226658 Disease Relevance 0.18 Pain Relevance 0.11
The influence of artemin (AR) on herpes-related pain responses was examined using mice infected with herpes simplex virus (HSV).
Regulation (influence) of AR associated with pain, cold sores and herpes simplex virus
6) Confidence 0.36 Published 2006 Journal In Vivo Section Abstract Doc Link 16900785 Disease Relevance 0.74 Pain Relevance 0.20
(Rosaceae) extracts on androgen receptor-mediated transcriptional regulation.
Regulation (regulation) of androgen receptor
7) Confidence 0.36 Published 2008 Journal J Ethnopharmacol Section Title Doc Link 18562138 Disease Relevance 0 Pain Relevance 0.14
However, despite the presence of possible AREs in the AR cDNA we did not observe any auto-regulation of kidney AR by androgens.
Regulation (regulation) of AR in kidney
8) Confidence 0.35 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1192819 Disease Relevance 0.13 Pain Relevance 0
Treating tumors with hAR-siRNA was as efficient as treating with the antagonist bicalutamide, which affects AR signaling in prostate and testes.
Regulation (affects) of AR in testes associated with cancer and antagonist
9) Confidence 0.35 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.90 Pain Relevance 0.05
In patients, castration or AR antagonists affect not only the tumor cells, but also normal tissues, triggering deleterious side effects.
Regulation (affect) of AR associated with cancer and antagonist
10) Confidence 0.35 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.74 Pain Relevance 0.05
Since the early 1990s, several procedures for antigen retrieval (AR) have been developed and proven to be effective for immunohistochemistry on light microscopic preparations in human brain tissue [4].
Regulation (effective) of AR in brain
11) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566591 Disease Relevance 0 Pain Relevance 0
The present study further substantiates this hypothesis by showing a strong down-regulation of AR target genes compared to the parental PC346C (Fig. 2).
Regulation (regulation) of AR
12) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.14 Pain Relevance 0
For example, in the present study, we discovered OAT as an AR-regulated gene, although it did not respond to DHT.
Regulation (regulated) of AR
13) Confidence 0.33 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 0 Pain Relevance 0
Differential regulation of genes near AR-occupied regions in LNCaP versus C4-2B cells
Regulation (regulation) of AR
14) Confidence 0.33 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 0.17 Pain Relevance 0
We therefore measured whether AR silencing affected the production of this hormone, and found no significant differences between untreated mice (0.88±0.69 ng/ml), and mice treated for 3 weeks with cont-siRNA (0.53±0.31 ng/ml) or panAR-siRNA (0.81±0.52 ng/ml).
Regulation (affected) of AR
15) Confidence 0.30 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.34 Pain Relevance 0.03
Down-regulation of AR by estrogens is a common feature of AR, and E2 was shown to reduce both the AR mRNA and protein levels of stickleback kidney.
Regulation (regulation) of AR in kidney
16) Confidence 0.30 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1192819 Disease Relevance 0.13 Pain Relevance 0
None of the three tested androgens regulated AR protein as determined by radioreceptor assay, or AR mRNA as determined by slot blot.
Regulation (regulated) of AR
17) Confidence 0.30 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1192819 Disease Relevance 0 Pain Relevance 0
At the core of androgen action is the regulation of Androgen Receptor (AR) by hormones such as testosterone.
Regulation (regulation) of Androgen
18) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.91 Pain Relevance 0
At the core of androgen action is the regulation of Androgen Receptor (AR) by hormones such as testosterone.
Regulation (regulation) of AR
19) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.91 Pain Relevance 0
Genetic alterations in the AR gene may cause impaired development resulting in androgen insensitivity syndromes (AIS) or in neurodegenerative diseases like Kennedy syndrome.
Regulation (alterations) of AR associated with syndrome, neurodegenerative disease, spinal muscular atrophy and androgen insensitivity
20) Confidence 0.27 Published 2001 Journal Eur. Urol. Section Abstract Doc Link 11684838 Disease Relevance 0.60 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox