INT99095

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Context Info
Confidence 0.37
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.51
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL4A4)
Anatomy Link Frequency
plasma 1
muscle 1
basement membrane 1
COL4A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
pain flank 1 95.56 Very High Very High Very High
Inflammation 12 95.12 Very High Very High Very High
imagery 1 80.32 Quite High
abdominal pain 1 79.08 Quite High
palliative 1 8.68 Low Low
metalloproteinase 16 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
iatrogenic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hematuria 3 99.98 Very High Very High Very High
Stomach Cancer 27 99.84 Very High Very High Very High
Neurilemmoma 7 99.46 Very High Very High Very High
Leptospirosis 29 98.96 Very High Very High Very High
Cancer 121 97.76 Very High Very High Very High
Flank Pain 1 95.56 Very High Very High Very High
INFLAMMATION 12 95.12 Very High Very High Very High
Hyperplasia 1 90.96 High High
Deafness 1 90.80 High High
Disease 58 87.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Benign familial hematuria associated with a novel COL4A4 mutation.
COL4A4 Binding (associated) of associated with hematuria
1) Confidence 0.37 Published 2001 Journal Pediatr. Nephrol. Section Title Doc Link 11685592 Disease Relevance 0.63 Pain Relevance 0.10
This study proved that the construct could produce a functional protein capable of trimerizing with COL4A3 and COL4A4 (Heikkilä et al. 2001).
COL4A4 Binding (trimerizing) of
2) Confidence 0.36 Published 2007 Journal Mamm Genome Section Body Doc Link PMC1998873 Disease Relevance 0.30 Pain Relevance 0
The diagnosis of schwannoma was supported by positive immunoreactivity for S-100 protein and collagen IV and absence of reactivity for keratin, muscle related antigens, and CD34 in both cases.
collagen IV Binding (immunoreactivity) of in muscle associated with neurilemmoma
3) Confidence 0.18 Published 2006 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 16699318 Disease Relevance 1.19 Pain Relevance 0.17
The percentage of immunoreactive positive cells and intensity for MMP9, MMP2, type IV collagen in GC were assessed.
IV collagen Binding (intensity) of associated with stomach cancer
4) Confidence 0.15 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 0.35 Pain Relevance 0
Immunostaining for fibronectin and type IV collagen was weak at the surface of the sheet but positive at the intercellular space (Figure 4).


type IV collagen Binding (Immunostaining) of
5) Confidence 0.06 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267690 Disease Relevance 0.27 Pain Relevance 0
The HAM’s basement membrane contains type IV collagen, ln-1, Ln-5, fibronectin, and collagen VII.
type IV collagen Binding (contains) of in basement membrane
6) Confidence 0.06 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693999 Disease Relevance 0.36 Pain Relevance 0.03
A stronger interaction was observed with laminin, collagen IV and plasma fibronectin.
collagen IV Binding (interaction) of in plasma
7) Confidence 0.01 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2386478 Disease Relevance 0.41 Pain Relevance 0

General Comments

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