INT99104

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Title
Documents 5
Total Number 5
Disease Relevance 3.31
Pain Relevance 2.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Npr1) plasma membrane (Npr1) intracellular (Npr1)
Anatomy Link Frequency
Spinal cord 1
heart 1
Npr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 24 99.90 Very High Very High Very High
Pain 8 99.90 Very High Very High Very High
neuralgia 4 99.90 Very High Very High Very High
nociceptor 1 99.90 Very High Very High Very High
Neuropathic pain 4 98.20 Very High Very High Very High
Spinal cord 5 97.46 Very High Very High Very High
central sensitization 2 91.24 High High
fibrosis 76 85.60 High High
Morphine 9 80.72 Quite High
Analgesic 4 78.56 Quite High
Disease Link Frequency Relevance Heat
Coronary Heart Disease 42 99.82 Very High Very High Very High
Natriuresis 16 99.72 Very High Very High Very High
INFLAMMATION 22 98.88 Very High Very High Very High
Neuropathic Pain 5 98.20 Very High Very High Very High
Body Weight 12 97.50 Very High Very High Very High
Hypertrophy 6 90.96 High High
Pain 6 90.88 High High
Cardiovascular Disorder Under Development 56 86.24 High High
Fibrosis 21 83.12 Quite High
Nociception 3 81.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because both natriuretic peptides and NPRA gene expression are upregulated in states of pressure overload, we speculated that the effects of the natriuretic peptides on cardiac structure and function would be most apparent after pressure overload.
Gene_expression (expression) of NPRA associated with natriuresis
1) Confidence 0.78 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15778276 Disease Relevance 0.62 Pain Relevance 0.07
cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I.
Gene_expression (produced) of NO-sensitive guanylyl cyclase associated with inflammation and neuropathic pain
2) Confidence 0.54 Published 2008 Journal J. Neurosci. Section Title Doc Link 18716216 Disease Relevance 1.00 Pain Relevance 1.66
Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2

Cardiac atrial natriuretic peptide (ANP) locally counteracts cardiac hypertrophy via the guanylyl cyclase-A (GC-A) receptor and cGMP production, but the downstream signalling pathways are unknown.

Gene_expression (production) of guanylyl cyclase associated with natriuresis and coronary heart disease
3) Confidence 0.21 Published 2010 Journal Basic Res Cardiol Section Title Doc Link PMC2916114 Disease Relevance 0.52 Pain Relevance 0
Spinal cord tissue contains two enzyme systems capable of producing monoxide gases which in turn are linked to the stimulation of soluble guanylate cyclase, nitric oxide synthase (NOS) which produces NO and heme oxygenase (HO) which produces CO.
Neg (NO) Gene_expression (produces) of guanylate cyclase in Spinal cord associated with spinal cord
4) Confidence 0.08 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11687280 Disease Relevance 0.34 Pain Relevance 0.79
Pioglitazone treatment increased heart–to–body weight ratios and cardiac BNP mRNA expression in AngII-infused mice but did not alter SBP, cardiomyocyte diameters, or ventricular ANP mRNA expression (Table 1, two-way ANOVA).
Gene_expression (expression) of ANP mRNA in heart associated with body weight
5) Confidence 0.07 Published 2008 Journal Diabetes Section Body Doc Link PMC2518499 Disease Relevance 0.84 Pain Relevance 0.28

General Comments

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