INT99116

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Context Info
Confidence 0.48
First Reported 2001
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 15
Total Number 17
Disease Relevance 7.33
Pain Relevance 13.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cacna2d3)
Anatomy Link Frequency
neuronal 1
nervous tissues 1
neocortex 1
spinal cord 1
amygdala 1
Cacna2d3 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 38 100.00 Very High Very High Very High
Gabapentin 23 99.98 Very High Very High Very High
pregabalin 111 99.80 Very High Very High Very High
Neurotransmitter 14 99.68 Very High Very High Very High
Hippocampus 12 98.48 Very High Very High Very High
amygdala 17 97.96 Very High Very High Very High
Spinal cord 18 97.40 Very High Very High Very High
Neuronal excitability 12 97.24 Very High Very High Very High
Fibrositis 204 90.40 High High
Post herpetic neuralgia 10 89.68 High High
Disease Link Frequency Relevance Heat
Convulsion 13 97.12 Very High Very High Very High
Anxiety Disorder 27 96.60 Very High Very High Very High
Manic Depressive Disorder 1 93.64 High High
Partial Seizures 10 92.40 High High
Sleep Disorders 214 90.40 High High
Herpes Simplex Virus Infection 10 89.48 High High
Pain 167 89.36 High High
Neuralgia 10 89.12 High High
Diabetic Neuropathy 6 88.96 High High
Diabetes Mellitus 8 88.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pregabalin subtly reduces the synaptic release of several neurotransmitters, apparently by binding to alpha2-delta subunits, and possibly accounting for its actions in vivo to reduce neuronal excitability and seizures.
alpha2-delta Binding (binding) of in neuronal associated with pregabalin, neurotransmitter, convulsion and neuronal excitability
1) Confidence 0.48 Published 2007 Journal Epilepsy Res. Section Abstract Doc Link 17126531 Disease Relevance 0.67 Pain Relevance 1.09
Several studies indicate that the pharmacology of pregabalin requires binding to alpha2-delta subunits, including structure-activity analyses of compounds binding to alpha2-delta subunits and pharmacology in mice deficient in binding at the alpha2-delta Type 1 protein.
alpha2-delta Spec (analyses) Binding (binding) of associated with pregabalin
2) Confidence 0.48 Published 2007 Journal Epilepsy Res. Section Abstract Doc Link 17126531 Disease Relevance 0.62 Pain Relevance 1.07
Several studies indicate that the pharmacology of pregabalin requires binding to alpha2-delta subunits, including structure-activity analyses of compounds binding to alpha2-delta subunits and pharmacology in mice deficient in binding at the alpha2-delta Type 1 protein.
alpha2-delta Spec (analyses) Binding (binding) of associated with pregabalin
3) Confidence 0.37 Published 2007 Journal Epilepsy Res. Section Abstract Doc Link 17126531 Disease Relevance 0.62 Pain Relevance 1.07
Several studies indicate that the pharmacology of pregabalin requires binding to alpha2-delta subunits, including structure-activity analyses of compounds binding to alpha2-delta subunits and pharmacology in mice deficient in binding at the alpha2-delta Type 1 protein.
alpha2-delta Binding (binding) of associated with pregabalin
4) Confidence 0.36 Published 2007 Journal Epilepsy Res. Section Abstract Doc Link 17126531 Disease Relevance 0.57 Pain Relevance 1.03
Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery.
alpha2-delta Binding (target) of associated with pregabalin and calcium channel
5) Confidence 0.36 Published 2007 Journal Epilepsy Res. Section Title Doc Link 17126531 Disease Relevance 0.69 Pain Relevance 1.00
Calcium channel alpha2-delta type 1 subunit is the major binding protein for pregabalin in neocortex, hippocampus, amygdala, and spinal cord: an ex vivo autoradiographic study in alpha2-delta type 1 genetically modified mice.
alpha2-delta Binding (binding) of in neocortex associated with pregabalin, calcium channel, hippocampus, amygdala and spinal cord
6) Confidence 0.36 Published 2006 Journal Brain Res. Section Title Doc Link 16460711 Disease Relevance 0.61 Pain Relevance 0.99
Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery.
alpha2-delta Binding (target) of associated with pregabalin and calcium channel
7) Confidence 0.31 Published 2007 Journal Epilepsy Res. Section Title Doc Link 17126531 Disease Relevance 0.69 Pain Relevance 1.00
Currently, there are two drugs on the market, gabapentin (Neurontin) and pregabalin (Lyrica), that are proposed to exert their therapeutic effect through binding to the alpha2-delta subunit of voltage-sensitive calcium channels.
alpha2-delta Binding (binding) of associated with pregabalin, calcium channel and gabapentin
8) Confidence 0.24 Published 2010 Journal Curr Opin Investig Drugs Section Abstract Doc Link 20571971 Disease Relevance 0 Pain Relevance 0.28
The alpha2-delta protein: an auxiliary subunit of voltage-dependent calcium channels as a recognized drug target.
alpha2-delta Binding (recognized) of associated with calcium channel
9) Confidence 0.24 Published 2010 Journal Curr Opin Investig Drugs Section Title Doc Link 20571971 Disease Relevance 0 Pain Relevance 0.29
Calcium channel alpha2-delta type 1 subunit is the major binding protein for pregabalin in neocortex, hippocampus, amygdala, and spinal cord: an ex vivo autoradiographic study in alpha2-delta type 1 genetically modified mice.
alpha2-delta Binding (binding) of in hippocampus associated with pregabalin, calcium channel, hippocampus, amygdala and spinal cord
10) Confidence 0.12 Published 2006 Journal Brain Res. Section Title Doc Link 16460711 Disease Relevance 0.61 Pain Relevance 0.99
Calcium channel alpha2-delta type 1 subunit is the major binding protein for pregabalin in neocortex, hippocampus, amygdala, and spinal cord: an ex vivo autoradiographic study in alpha2-delta type 1 genetically modified mice.
alpha2-delta Binding (binding) of in spinal cord associated with pregabalin, calcium channel, hippocampus, amygdala and spinal cord
11) Confidence 0.12 Published 2006 Journal Brain Res. Section Title Doc Link 16460711 Disease Relevance 0.61 Pain Relevance 0.99
Calcium channel alpha2-delta type 1 subunit is the major binding protein for pregabalin in neocortex, hippocampus, amygdala, and spinal cord: an ex vivo autoradiographic study in alpha2-delta type 1 genetically modified mice.
alpha2-delta Binding (binding) of in amygdala associated with pregabalin, calcium channel, hippocampus, amygdala and spinal cord
12) Confidence 0.12 Published 2006 Journal Brain Res. Section Title Doc Link 16460711 Disease Relevance 0.61 Pain Relevance 0.99
Although recent findings indicate that drug binding to alpha2-delta-1 is required for pharmacology of pregabalin and gabapentin, previous work has not addressed the location of alpha2-delta-1 protein within nervous tissues.
alpha2-delta Binding (binding) of in nervous tissues associated with pregabalin and gabapentin
13) Confidence 0.09 Published 2008 Journal Neuroscience Section Abstract Doc Link 18616987 Disease Relevance 0 Pain Relevance 0.66
Inhibition of gabapentin binding to alpha2delta-2 by selected amino acids and gabapentin analogs produced a binding profile similar, but not identical to that of alpha2delta-1.
alpha2delta-2 Binding (binding) of associated with gabapentin
14) Confidence 0.08 Published 2001 Journal J. Membr. Biol. Section Abstract Doc Link 11687876 Disease Relevance 0 Pain Relevance 0.40
Of the four subtypes of alpha2-delta, only alpha2-delta types 1 and 2 (alpha2-delta-1 and alpha2-delta-2) bind the drugs gabapentin (Neurontin) and pregabalin (Lyrica).
alpha2-delta Binding (bind) of associated with pregabalin and gabapentin
15) Confidence 0.07 Published 2008 Journal Neuroscience Section Abstract Doc Link 18616987 Disease Relevance 0 Pain Relevance 0.55
Of the four subtypes of alpha2-delta, only alpha2-delta types 1 and 2 (alpha2-delta-1 and alpha2-delta-2) bind the drugs gabapentin (Neurontin) and pregabalin (Lyrica).
alpha2-delta Binding (bind) of associated with pregabalin and gabapentin
16) Confidence 0.07 Published 2008 Journal Neuroscience Section Abstract Doc Link 18616987 Disease Relevance 0 Pain Relevance 0.55
An alternative first line medication approach is an alpha 2 delta ligand, which may be particularly helpful in patients with prominent sleep disturbances or anxiety.
alpha 2 delta Binding (ligand) of associated with anxiety disorder
17) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779399 Disease Relevance 1.02 Pain Relevance 0.59

General Comments

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