INT99126

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.37
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LDHA) small molecule metabolic process (LDHA) oxidoreductase activity (LDHA)
cytoplasm (LDHA)
Anatomy Link Frequency
blood 2
alveolar macrophages 2
platelet 2
LDHA (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 9 97.84 Very High Very High Very High
cytokine 3 93.92 High High
Pain 1 85.36 High High
cva 13 75.92 Quite High
Glutamate 54 73.44 Quite High
alcohol 6 66.48 Quite High
chemokine 1 31.88 Quite Low
corticosteroid 12 5.00 Very Low Very Low Very Low
Versed 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis 35 100.00 Very High Very High Very High
Chronic Hepatitis 31 100.00 Very High Very High Very High
Adult Respiratory Distress Syndrome 21 99.92 Very High Very High Very High
Cirrhosis 57 99.76 Very High Very High Very High
Myocardial Infarction 9 99.68 Very High Very High Very High
Oliguria 1 99.04 Very High Very High Very High
Cv Unclassified Under Development 9 98.52 Very High Very High Very High
Infection 17 98.12 Very High Very High Very High
Pleural Effusion 1 97.76 Very High Very High Very High
Shock 1 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This conflicts with previous data where increased glass fiber concentration decreased chemiluminescence and increased LDH in rat alveolar macrophages but major length-dependent effects were evident.
Negative_regulation (decreased) of Positive_regulation (increased) of LDH in alveolar macrophages
1) Confidence 0.43 Published 2006 Journal Part Fibre Toxicol Section Body Doc Link PMC1459188 Disease Relevance 0 Pain Relevance 0
Analysis of total ERK1/2 (42/44 kDa), a principle kinase in growth factor signaling, showed a slight reduction in AH, and moderate increases in CH, LDH, and CIRR.
Negative_regulation (reduction) of Positive_regulation (increases) of LDH associated with chronic hepatitis, cirrhosis and hepatitis
2) Confidence 0.24 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 2.18 Pain Relevance 0.03
However, fatal outcomes were associated with decreased platelet counts, increased LDH, ARDS, cardiac failure, and lack of antiviral treatment in the bivariate analyses.
Spec (analyses) Negative_regulation (decreased) of Spec (analyses) Positive_regulation (increased) of LDH in platelet associated with adult respiratory distress syndrome and myocardial infarction
3) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2515635 Disease Relevance 0.37 Pain Relevance 0
Sustained activation of lactate dehydrogenase insufficiently replenishes NAD+.
Negative_regulation (replenishes) of Positive_regulation (activation) of lactate dehydrogenase
4) Confidence 0.09 Published 2010 Journal Crit Care Section Body Doc Link PMC2875528 Disease Relevance 0.44 Pain Relevance 0.20
Laboratory parameters disclosed elevated transaminase, lactate dehydrogenase, uric acid and D-dimer blood levels.
Negative_regulation (disclosed) of Positive_regulation (elevated) of lactate dehydrogenase in blood
5) Confidence 0.02 Published 2001 Journal Ann. Ital. Med. Int. Section Abstract Doc Link 11688358 Disease Relevance 1.38 Pain Relevance 0.09

General Comments

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