INT99138

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Context Info
Confidence 0.01
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.73
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Coq10a) kinase activity (Insrr) cellular_component (Coq10a)
biological_process (Coq10a)
Coq10a (Mus musculus)
Insrr (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 5 100.00 Very High Very High Very High
Potency 1 97.36 Very High Very High Very High
Opioid 8 97.04 Very High Very High Very High
MU agonist 2 94.72 High High
Morphine 5 93.72 High High
analgesia 3 90.88 High High
dorsal root ganglion 3 86.68 High High
Analgesic 1 75.16 Quite High
tolerance 2 75.00 Quite High
addiction 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 3 95.04 Very High Very High Very High
Vibrio Infection 2 88.60 High High
Ganglion Cysts 3 86.68 High High
Nociception 1 78.56 Quite High
Drug Dependence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study provides more direct evidence that endogenous GM1 plays a physiologic role in regulating excitatory opioid receptor functions in vivo by demonstrating that cotreatment with remarkably low doses of CTX-B (10 ng/kg, s.c.) selectively blocks hyperalgesic effects elicited by morphine or by a kappa opioid agonist, thereby unmasking potent opioid analgesia.
GM1 Regulation (regulating) of receptor associated with hyperalgesia, mu agonist, opioid receptor, opioid, analgesia and morphine
1) Confidence 0.01 Published 2001 Journal Brain Res. Section Abstract Doc Link 11689159 Disease Relevance 0.73 Pain Relevance 1.81

General Comments

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