INT99150

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Context Info
Confidence 0.79
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 6.20
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VCAM1) aging (VCAM1) cell adhesion (VCAM1)
plasma membrane (VCAM1)
Anatomy Link Frequency
endothelial cells 1
stellate cells 1
umbilical vein 1
HGF 1
eosinophil 1
VCAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 26 99.98 Very High Very High Very High
dexamethasone 40 97.84 Very High Very High Very High
Inflammation 86 96.48 Very High Very High Very High
cINOD 2 82.60 Quite High
Inflammatory mediators 1 80.12 Quite High
Inflammatory marker 6 76.48 Quite High
Analgesic 1 69.96 Quite High
Neuropeptide 1 68.56 Quite High
Dismenorea 1 65.36 Quite High
chemokine 3 54.88 Quite High
Disease Link Frequency Relevance Heat
Adhesions 44 100.00 Very High Very High Very High
Hypertension 10 98.68 Very High Very High Very High
Nicotine Addiction 79 98.16 Very High Very High Very High
Cancer 86 97.16 Very High Very High Very High
INFLAMMATION 100 96.48 Very High Very High Very High
Cirrhosis 46 96.40 Very High Very High Very High
Cardiovascular Disease 41 90.76 High High
Atherosclerosis 41 85.28 High High
Disease 40 83.44 Quite High
Hypersensitivity 16 83.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Co-localization of alpha-smooth muscle actin (red) and VCAM-1 (green) in stellate cells (orange) in hepatic tissues is shown by immunofluorescence analysis (Figure 8C).
Localization (localization) of VCAM-1 in stellate cells
1) Confidence 0.79 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.12 Pain Relevance 0.09
In culture, hematein also significantly inhibited the secretion of soluble VCAM-1 and of monocyte chemotactic protein-1 (MCP-1) respectively induced by tumor necrotic factor alpha (TNF-alpha) and mildly oxidized low density lipoprotein in human umbilical vein endothelial cell (HUVEC) culture.
Localization (secretion) of VCAM-1 in umbilical vein associated with cancer
2) Confidence 0.67 Published 2001 Journal Atherosclerosis Section Abstract Doc Link 11689202 Disease Relevance 0.43 Pain Relevance 0.11
The simultaneous presence of FOXF1, VCAM1, and HGF in colon and urinary tract SMC gene clusters (Figure 4D) suggests that their regulatory relationship may be preserved in these SMCs.
Localization (presence) of VCAM1 in HGF
3) Confidence 0.58 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.15 Pain Relevance 0.10
-induced ECP release and their adhesion to immobilised VCAM-1, ICAM-1 and IgG.
Localization (immobilised) of VCAM-1 associated with adhesions
4) Confidence 0.51 Published 2005 Journal Clin Mol Allergy Section Body Doc Link PMC1131914 Disease Relevance 0.57 Pain Relevance 0.42
induced eosinophil degranulation, cytokines release and adhesion to VCAM-1, ICAM-1 and IgG.


Localization (release) of VCAM-1 in eosinophil associated with adhesions and cytokine
5) Confidence 0.51 Published 2005 Journal Clin Mol Allergy Section Body Doc Link PMC1131914 Disease Relevance 0.90 Pain Relevance 0.50
and bacterial lipopolysaccharide (LPS), increase the expression of cell adhesion molecules (CAMs) including intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin on endothelial cells.2 Thus, upon inflammatory stimulation, the endothelial barrier function is rapidly lost and preformed P-selectin is translocated to the luminal surface of endothelial cells, followed by expression and release of E-selectin, ICAM-1, and VCAM-1 – substances that regulate the attachment and trans-endothelial migration of leukocytes.
Localization (release) of VCAM-1 in endothelial cells associated with inflammation and adhesions
6) Confidence 0.45 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2828103 Disease Relevance 1.82 Pain Relevance 0.25
Further evidence in support of pro-adhesive events elicited in the vascular wall by CS constituents has been provided by Mazzone and colleagues who found sICAM and sVCAM to be significantly elevated in hypertensive smokers as compared to non-smoking hypertensive patients (

Mazzone and others, 2001

), a finding that further underlines the independence of smoking from other known risk factors for CVD.

Localization (found) of sVCAM associated with nicotine addiction, cardiovascular disease and hypertension
7) Confidence 0.02 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688374 Disease Relevance 1.21 Pain Relevance 0.12

General Comments

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