INT99156

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Context Info
Confidence 0.38
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 0.57
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSPA5) endoplasmic reticulum (HSPA5) ATPase activity (HSPA5)
nucleus (HSPA5) protein binding, bridging (HSPA5)
Anatomy Link Frequency
fibroblasts 1
HSPA5 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 5 99.68 Very High Very High Very High
dopamine receptor 5 98.22 Very High Very High Very High
Serotonin 2 97.40 Very High Very High Very High
GABA receptor 2 96.98 Very High Very High Very High
Glutamate receptor 6 96.48 Very High Very High Very High
Neurotransmitter 4 95.90 Very High Very High Very High
Inflammation 9 94.36 High High
Analgesic 1 89.40 High High
Opioid 4 56.24 Quite High
chemokine 6 42.40 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 10 94.36 High High
Schizophrenia 100 84.56 Quite High
Bordatella Infection 3 52.80 Quite High
Disease 28 25.12 Quite Low
Necrosis 1 10.56 Low Low
Cancer 47 10.20 Low Low
Heart Rate Under Development 3 5.00 Very Low Very Low Very Low
Mental Disorders 3 5.00 Very Low Very Low Very Low
Osteoarthritis 3 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aspirin and salicylate bind to immunoglobulin heavy chain binding protein (BiP) and inhibit its ATPase activity in human fibroblasts.
immunoglobulin heavy chain binding protein Binding (bind) of in fibroblasts associated with aspirin
1) Confidence 0.38 Published 2001 Journal FASEB J. Section Title Doc Link 11689471 Disease Relevance 0.18 Pain Relevance 0.42
Among the four well-known neurotransmitter pathways (glutamate receptor signaling, GABA receptor signaling, serotonin receptor signaling and dopamine receptor signaling), GRB2 appeared in all the four pathways and HSPA5 in three pathways, and the interaction between GRB2 and HSPA5 appeared in three pathways.
HSPA5 Spec (appeared) Binding (interaction) of associated with neurotransmitter, dopamine receptor, gaba receptor, glutamate receptor and serotonin
2) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894047 Disease Relevance 0.28 Pain Relevance 0.31
Localization patterns of Nuc, COX-2 and GRP-78 systematically matched with each other, suggesting that Nuc and COX-2 both reside in the Golgi and ER structures [44].
GRP-78 Binding (matched) of
3) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2373884 Disease Relevance 0 Pain Relevance 0
Interestingly, Bip interaction was lost with the non-glycosylated form of the ?
Bip Binding (interaction) of
4) Confidence 0.11 Published 2010 Journal J Mol Signal Section Body Doc Link PMC2954983 Disease Relevance 0 Pain Relevance 0
Although interactions with calreticulin, PDI and GRP94 appear to be conserved through all receptor pairs, differences in the interaction pattern can be observed in the case of Bip, which interacts only with the ?
Bip Binding (interacts) of
5) Confidence 0.10 Published 2010 Journal J Mol Signal Section Body Doc Link PMC2954983 Disease Relevance 0.05 Pain Relevance 0.06
Although interactions with calreticulin, PDI and GRP94 appear to be conserved through all receptor pairs, differences in the interaction pattern can be observed in the case of Bip, which interacts only with the ?
Bip Binding (case) of
6) Confidence 0.10 Published 2010 Journal J Mol Signal Section Body Doc Link PMC2954983 Disease Relevance 0.05 Pain Relevance 0.05

General Comments

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