INT99163

Context Info Confidence 0.49 First Reported 2001 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 18 Total Number 19 Disease Relevance 16.02 Pain Relevance 7.91

extracellular space (Cd14) plasma membrane (Cd14) response to stress (Cd14)

Anatomy Link Frequency monocytes 3 TMJ 2 spinal nerve 1 plasma 1 vessels 1 Cd14 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Snapping jaw 26 100.00 nud 260 99.84 cytokine 31 99.60 metalloproteinase 12 99.46 Cancer pain 49 99.12 Angina 34 98.84 Inflammation 135 96.56 Potency 11 93.84 c fibre 2 87.92 substance P 4 86.64

Disease Link Frequency Relevance Heat Cancer 39 100.00 Temporomandibular Joint Syndrome 26 100.00 Fibromyalgia 12 100.00 Necrosis 3 100.00 Pressure And Volume Under Development 10 99.88 Dyspepsia 260 99.84 Respiratory Syncytial Virus 232 99.78 Bone Cancer 56 99.32 Acquired Immune Deficiency Syndrome Or Hiv Infection 87 99.24 Cv General 3 Under Development 26 98.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Since CD14 is known to be up-regulated in cells exposed to LPS, these observations suggest that prolonged Mg-deficiency results in increased intestinal permeability to bacterial products that induce the endotoxin receptor in cells localized to myocardial and intestinal tissues.

Positive_regulation (up-regulated) of CD14

1) Confidence 0.49 Published 2005 Journal Mol. Cell. Biochem. Section Abstract Doc Link 16180088 Disease Relevance 0.30 Pain Relevance 0.32

Estrogenic group differences in CFA induced swelling were independent of TMJ CD14+, CD14+/CD16+ or CD16+ cell numbers suggesting E2 action on the CFA immune response primarily excluded CD16 receptor action.

Neg (independent) Positive_regulation (independent) of CD14 in TMJ associated with pressure and volume under development and snapping jaw

2) Confidence 0.43 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 16153820 Disease Relevance 1.79 Pain Relevance 1.02

Estrogenic group differences in CFA induced swelling were independent of TMJ CD14+, CD14+/CD16+ or CD16+ cell numbers suggesting E2 action on the CFA immune response primarily excluded CD16 receptor action.

Neg (independent) Positive_regulation (independent) of CD14 in TMJ associated with pressure and volume under development and snapping jaw

3) Confidence 0.43 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 16153820 Disease Relevance 1.79 Pain Relevance 1.02

The spinal lumbar mRNA expression of ITGAM, TLR4, and CD14 was upregulated at 4 h post surgery, CD14 peaked 4 days after spinal nerve transection while ITGAM and TLR4 continued to increase until day 14 and returned to almost normal levels by postoperative day 28.

Positive_regulation (upregulated) of CD14 in spinal nerve

4) Confidence 0.43 Published 2004 Journal Neurochem. Int. Section Abstract Doc Link 15145554 Disease Relevance 0.42 Pain Relevance 0.35

It has been reported that the transcriptional activity of the CD14-159T allele was found, by the luciferase reporter assay, to be increased in monocytic Mono Mac 6 cells [35].

Positive_regulation (increased) of CD14

5) Confidence 0.42 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266053 Disease Relevance 1.32 Pain Relevance 0.48

Baseline MC membrane fluidity measurements and sCD14 levels in patients with CCS class IV angina were significantly increased on comparison with MCs from normal volunteers (p < 0.001).

Positive_regulation (increased) of sCD14

6) Confidence 0.40 Published 2001 Journal J. Am. Coll. Cardiol. Section Body Doc Link 11691505 Disease Relevance 0.06 Pain Relevance 0

Meanwhile, the CD14 genotype distribution in FD was 31CC (28.4%), 56CT (51.4%), 22TT (20.2%).

Positive_regulation (distribution) of CD14 associated with nud

7) Confidence 0.39 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2266053 Disease Relevance 1.07 Pain Relevance 0.46

Meanwhile, the CD14 genotype distribution in FD was 31CC (28.4%), 56CT (51.4%), 22TT (20.2%).

Positive_regulation (distribution) of CD14 associated with nud

8) Confidence 0.39 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266053 Disease Relevance 0.59 Pain Relevance 0.16

Homozigous carriers of the T allele also have a significant increase in serum level of soluble CD14 and correlation with high IFN?

Positive_regulation (increase) of CD14

9) Confidence 0.39 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266053 Disease Relevance 1.23 Pain Relevance 0.42

A two- to three-fold increase in the mRNA expression levels of microglial activation markers CD11b and CD14 was observed in bone cancer pain rats at days 6 and 12 after inoculation (n = 4, ANOVA1w, P < 0.01, post hoc Dunnett testing).

Positive_regulation (increase) of CD14 associated with cancer pain and bone cancer

10) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.68 Pain Relevance 0.58

More recently, Ancuta et al. (2008) showed that elevated sCD14 and lipopolysachharide (LPS) levels are associated with HAD.

Positive_regulation (elevated) of sCD14

11) Confidence 0.28 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 1.37 Pain Relevance 0.13

Enhanced levels of oxidized low-density lipoprotein prime monocytes to cytokine overproduction via upregulation of CD14 and toll-like receptor 4 in unstable angina.

Positive_regulation (upregulation) of CD14 in monocytes associated with angina and cytokine

12) Confidence 0.24 Published 2007 Journal Arterioscler. Thromb. Vasc. Biol. Section Title Doc Link 17600225 Disease Relevance 0.10 Pain Relevance 0.28

Similarly to c-fms, expression of the lipopolysacharide receptor CD14 was significantly upregulated by low doses (10 and 100 nM) of RSV analogues PDM02 and PDM10, whereas high doses (1 ?

Positive_regulation (upregulated) of CD14 associated with fibromyalgia and respiratory syncytial virus

13) Confidence 0.23 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.75 Pain Relevance 0.04

We conclude that treatment with RSV analogues induces a similar expression pattern of the monocytic markers c-fms and CD14, which is clearly distinct from the effects on RANK expression.

Positive_regulation (induces) of CD14 associated with fibromyalgia and respiratory syncytial virus

14) Confidence 0.23 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.80 Pain Relevance 0.05

RESULTS: PTCA induced a marked up-regulation of CD18, CD11b, CD14 and GPIIb/IIIa with L-selectin shedding and reduced SO formation, whereas only minor L-selectin down-regulation and decreased SO production indicated activation in UA.

Positive_regulation (up-regulation) of CD14 in CD14

15) Confidence 0.16 Published 2005 Journal Int. J. Cardiol. Section Body Doc Link 15771923 Disease Relevance 0.15 Pain Relevance 0

The CRP levels in serum and the percentages of cell surface antigens had no correlation with extent of coronary artery disease (no differences among one, two or three vessels) but Type C lesion had significantly higher percentages of HLA-DR, CD14, CD16+56 and the serum levels of CRP than Type A and Type B lesions.

Positive_regulation (percentages) of CD14 in vessels associated with coronary artery disease

16) Confidence 0.08 Published 2002 Journal Jpn Heart J Section Abstract Doc Link 12558124 Disease Relevance 1.34 Pain Relevance 1.03

In conclusion, the progression of coronary artery disease was mirrored by an increasing MMP-9/TIMP-1 ratio in the peripheral circulating CD14+ monocytes and serum, respectively.

Positive_regulation (circulating) of CD14 in monocytes associated with coronary artery disease and metalloproteinase

17) Confidence 0.08 Published 2010 Journal Am. J. Cardiol. Section Abstract Doc Link 20152234 Disease Relevance 0.61 Pain Relevance 0.74

Concurrent elevations of tissue CD14, a high affinity receptor for lipopolyssacharide, suggest that intestinal permeability may be compromised leading to endotoxemia.

Positive_regulation (elevations) of CD14 associated with endotoxemia

18) Confidence 0.07 Published 2006 Journal Heart Fail Rev Section Abstract Doc Link 16819576 Disease Relevance 0.90 Pain Relevance 0.68

Previously, we reported an increase in soluble tumor necrosis factor-alpha receptor two (sTNF-R2) and soluble CD14 (sCD14) in the plasma of HIV-seropositive individuals with neurocognitive dysfunction compared to their cognitively intact counterparts.

Positive_regulation (increase) of sCD14 in plasma associated with necrosis, cancer and acquired immune deficiency syndrome or hiv infection

19) Confidence 0.01 Published 2004 Journal AIDS Res. Hum. Retroviruses Section Abstract Doc Link 15000697 Disease Relevance 0.75 Pain Relevance 0.13

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