INT99170

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Context Info
Confidence 0.11
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.20
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Mc1r, Tyr) cell proliferation (Tyr) signal transduction (Mc1r)
oxidoreductase activity (Tyr) plasma membrane (Mc1r) cytoplasm (Tyr)
Mc1r (Mus musculus)
Tyr (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 12 98.10 Very High Very High Very High
antagonist 6 97.86 Very High Very High Very High
melanocortin 1 receptor 2 75.00 Quite High
Potency 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Skin Cancer 2 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antagonist and agonist activities of chemically synthetized mouse agouti protein fragment (91-131) (AP91-131) at the melanocortin type-1 receptor (MC1-R) were assessed using B 16-F1 mouse melanoma cells in vitro and the following assay systems: (i) receptor binding, (ii) adenylate cyclase, (iii) tyrosinase, (iv) melanin production, and (v) cell proliferation.
melanocortin type-1 receptor Binding (binding) of tyrosinase associated with antagonist, agonist and skin cancer
1) Confidence 0.11 Published 2001 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 11693171 Disease Relevance 0.10 Pain Relevance 0.32
Antagonist and agonist activities of chemically synthetized mouse agouti protein fragment (91-131) (AP91-131) at the melanocortin type-1 receptor (MC1-R) were assessed using B 16-F1 mouse melanoma cells in vitro and the following assay systems: (i) receptor binding, (ii) adenylate cyclase, (iii) tyrosinase, (iv) melanin production, and (v) cell proliferation.
MC1-R Binding (binding) of tyrosinase associated with antagonist, agonist and skin cancer
2) Confidence 0.11 Published 2001 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 11693171 Disease Relevance 0.10 Pain Relevance 0.32

General Comments

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