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Context Info
Confidence 0.22
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.08
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Pomc, Tyr) cell-cell signaling (Pomc) pigmentation (Tyr)
cell proliferation (Tyr) extracellular space (Pomc) generation of precursor metabolites and energy (Pomc)
Pomc (Mus musculus)
Tyr (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 6 94.52 High High
antagonist 3 76.72 Quite High
melanocortin 1 receptor 1 75.00 Quite High
Potency 1 36.56 Quite Low
Disease Link Frequency Relevance Heat
Skin Cancer 1 84.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alpha-MSH-induced tyrosinase activation and melanin production were completely inhibited by a 100-fold higher concentration of AP9 l -131; the IC50 values for AP91-131 in thetwo assay systems were 91 +/- 22 nM and 95 +/- 15 nM respectively.
Negative_regulation (inhibited) of Alpha-MSH Positive_regulation (activation) of tyrosinase
1) Confidence 0.22 Published 2001 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 11693171 Disease Relevance 0.08 Pain Relevance 0.35

General Comments

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