INT99206

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Context Info
Confidence 0.08
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.41
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Edc4) cytoplasm (Edc4)
Anatomy Link Frequency
nervous tissues 1
Edc4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 72 100.00 Very High Very High Very High
ischemia 201 92.72 High High
Spinal cord 2 84.72 Quite High
Central nervous system 1 76.64 Quite High
cerebral cortex 4 73.92 Quite High
Hippocampus 43 72.56 Quite High
Dorsal horn 1 70.16 Quite High
Inflammation 1 66.16 Quite High
Dynorphin 1 47.36 Quite Low
Opioid 1 42.40 Quite Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 177 92.72 High High
Cognitive Disorder 48 92.16 High High
Death 18 76.92 Quite High
Apoptosis 15 75.16 Quite High
Targeted Disruption 27 70.16 Quite High
INFLAMMATION 1 66.16 Quite High
Brain Hemorrhage 6 30.60 Quite Low
Cv Unclassified Under Development 18 5.00 Very Low Very Low Very Low
Stroke 18 5.00 Very Low Very Low Very Low
Middle Cerebral Artery Infarction 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The study further showed that EDC was incapable of recruiting nuclear ER?
Gene_expression (incapable) of EDC
1) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.13 Pain Relevance 0.06
It should be noted that the enhanced expression of BDNF by EDC was delayed in our study as compared to the CREB activation, as BDNF elevation occurred at 6–24h after reperfusion, while pCREB elevation occurred as early as 10min post-reperfusion.
Gene_expression (expression) of EDC associated with bdmf
2) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.77 Pain Relevance 0.39
EDC treatment significant increased p-ERK levels in the CA1 region from 10 min - 6h, as compared to the reperfusion or vehicle control.
Gene_expression (levels) of EDC
3) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.45 Pain Relevance 0.22
Examining sites of receptor mRNA expression by Northern blot we show that NK4 mRNA is expressed in numerous rat tissues, in contrast to the NK3 receptor which has been shown to have a distribution principally in nervous tissues.
Gene_expression (expressed) of NK4 mRNA in nervous tissues
4) Confidence 0.02 Published 2001 Journal Recept. Channels Section Abstract Doc Link 11697232 Disease Relevance 0.07 Pain Relevance 0.26

General Comments

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