INT99237

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Context Info
Confidence 0.77
First Reported 2001
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 84
Total Number 85
Disease Relevance 38.68
Pain Relevance 20.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk3) plasma membrane (Ntrk3) kinase activity (Ntrk3)
cytoplasm (Ntrk3)
Anatomy Link Frequency
neurons 24
embryos 6
muscle 4
sensory neurons 3
mechanoreceptors 3
Ntrk3 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 271 100.00 Very High Very High Very High
Calcium channel 6 100.00 Very High Very High Very High
trigeminal ganglion 3086 99.96 Very High Very High Very High
Central nervous system 111 99.88 Very High Very High Very High
nociceptor 1472 99.84 Very High Very High Very High
dorsal root ganglion 474 99.82 Very High Very High Very High
neurotrophin 3 15 99.72 Very High Very High Very High
Hippocampus 11 99.68 Very High Very High Very High
calcitonin gene related peptide 451 99.60 Very High Very High Very High
Pyramidal cell 10 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 4206 99.96 Very High Very High Very High
Nociception 415 99.90 Very High Very High Very High
Targeted Disruption 2026 99.88 Very High Very High Very High
Panic Disorder 8 99.84 Very High Very High Very High
Neurodegenerative Disease 209 99.60 Very High Very High Very High
Stress 30 99.60 Very High Very High Very High
Death 393 97.72 Very High Very High Very High
Pain 226 96.44 Very High Very High Very High
Repression 311 95.36 Very High Very High Very High
Sprains And Strains 35 95.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Susceptibility to stress in transgenic mice overexpressing TrkC, a model of panic disorder.
Gene_expression (overexpressing) of TrkC associated with panic disorder, targeted disruption and stress
1) Confidence 0.77 Published 2010 Journal J Psychiatr Res Section Title Doc Link 19698958 Disease Relevance 1.09 Pain Relevance 0.11
To this aim, we have analyzed the functionality of HPA axis and the behavioral consequences of different types of stressful conditions in a mouse model of panic disorder, which overexpresses TrkC, the high affinity-receptor for NT-3 (TgNTRK3).
Gene_expression (overexpresses) of TrkC associated with panic disorder
2) Confidence 0.77 Published 2010 Journal J Psychiatr Res Section Abstract Doc Link 19698958 Disease Relevance 1.11 Pain Relevance 0.13
These data indicate that the abrogation of Necdin results in a partial loss of sensory neurons expressing TrkA and TrkC receptors.
Gene_expression (expressing) of TrkC in sensory neurons
3) Confidence 0.72 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.32 Pain Relevance 0
At early developmental stages, most DRG neurons synthesize TrkC protein first before the onset of TrkB synthesis.
Gene_expression (synthesize) of TrkC in developmental stages associated with dorsal root ganglion
4) Confidence 0.69 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 1.13 Pain Relevance 0.41
Subsequently, the ratio of TrkB/TrkC-hybrid neurons declines to produce DRG neurons that synthesize either TrkC or TrkB (Figure 1a).
Gene_expression (synthesize) of TrkC in neurons associated with dorsal root ganglion
5) Confidence 0.69 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 1.18 Pain Relevance 0.43
sites and/or factors other than BDNF/TrkB signaling such as NT3/TrkC.
Gene_expression (signaling) of TrkC
6) Confidence 0.65 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2964534 Disease Relevance 0 Pain Relevance 0
Later in development and in adult, we showed that PV-fibers and CGRP-fibers that express TrkC and TrkA respectively are correctly patterned; however we detected a reduction in the number of fibers.
Gene_expression (express) of TrkC associated with nociception
7) Confidence 0.63 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.26 Pain Relevance 0.12
At all stages, Trka, Trkb and Trkc expressing cells were detected in mutant mice as shown at E13.5 (Fig. 2G–I).
Gene_expression (expressing) of Trkc
8) Confidence 0.63 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.07 Pain Relevance 0
The abrogation of Necdin results in a relatively selective loss of neurons in DRGs: TrkA and TrkC cell populations are reduced but not TrkB population.
Neg (not) Gene_expression (population) of TrkC in neurons associated with nociception
9) Confidence 0.63 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.52 Pain Relevance 0
Thus this specific defect of the TrkC neurons might suggest an involvement of Necdin in axonal growth.
Gene_expression (neurons) of TrkC in neurons
10) Confidence 0.63 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.37 Pain Relevance 0.08
In DRG neurogenesis, dynamic changes are observed during the synthesis of neurotrophin receptors (TrkB, TrkC) [25].
Gene_expression (synthesis) of TrkC associated with dorsal root ganglion and neurodegenerative disease
11) Confidence 0.60 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 1.20 Pain Relevance 0.47
Ectopic synthesis of TrkC receptor per se influences the lineage commitment of DRG neurons [44], while Runx3 plays a crucial role in TrkB/TrkC status [25,45].
Gene_expression (synthesis) of TrkC in neurons associated with dorsal root ganglion
12) Confidence 0.60 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.64 Pain Relevance 0.18
Subsequently, the ratio of TrkB/TrkC-hybrid neurons declines to produce DRG neurons that synthesize either TrkC or TrkB (Figure 1a).
Gene_expression (ratio) of TrkC in neurons associated with dorsal root ganglion
13) Confidence 0.60 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 1.13 Pain Relevance 0.45
Plausible candidates are TrkC/TrkA signalling and the basic helix-loop-helix transcription factors Ngn2/Ngn1; however, a genetic study has excluded these possibilities [25].
Gene_expression (signalling) of TrkC
14) Confidence 0.60 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.62 Pain Relevance 0.18
During this segregation, Runx3 is observed in most TrkC+ neurons but not in TrkB+ neurons [25].
Gene_expression (neurons) of TrkC in neurons
15) Confidence 0.60 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 1.18 Pain Relevance 0.45
Neurotrophin-3 (NT-3), its cognate receptor trkC, and voltage-gated calcium channels are coexpressed by embryonic pyramidal neurons before target contact, but their functions at this stage of development are still unclear.
Gene_expression (coexpressed) of trkC in pyramidal neurons associated with pyramidal cell and calcium channel
16) Confidence 0.59 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11698591 Disease Relevance 0 Pain Relevance 0.24
Additionally we found no significant change in the post-axotomy expression of Ntrk2 (TrkB; the primary BDNF receptor) and Ntrk3 (TrkC/NT-3; neurotrophin 3).
Gene_expression (expression) of Ntrk3 associated with neurotrophin 3
17) Confidence 0.58 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.20 Pain Relevance 0.08
Additionally we found no significant change in the post-axotomy expression of Ntrk2 (TrkB; the primary BDNF receptor) and Ntrk3 (TrkC/NT-3; neurotrophin 3).
Gene_expression (expression) of TrkC associated with neurotrophin 3
18) Confidence 0.58 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.25 Pain Relevance 0.08
However, we have shown that the lack of Necdin leads to a loss of TrkC expressing cells that in turn could explain the absence or reduction of afferent projections.
Gene_expression (expressing) of TrkC
19) Confidence 0.56 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.41 Pain Relevance 0.08
We performed three separate double labelling experiments with a p75NTR riboprobe and either an anti-Islet1/2 antibody (Fig. 4A), an anti-Necdin antibody (Fig 4B), or an anti-Runx3 antibody, labelling the TrkC expressing neurons (Fig. 4C).
Gene_expression (expressing) of TrkC in neurons
20) Confidence 0.56 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.30 Pain Relevance 0

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