INT99258

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Context Info
Confidence 0.25
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 2.79
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Aph1a) Golgi apparatus (Aph1a) endoplasmic reticulum (Aph1a)
Anatomy Link Frequency
Notch 2
cleavage 1
Aph1a (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 18 99.84 Very High Very High Very High
Abeta 5 99.08 Very High Very High Very High
Inflammation 1 85.56 High High
diclofenac 1 75.68 Quite High
aspirin 1 72.64 Quite High
Inflammatory response 1 68.88 Quite High
Hippocampus 2 45.60 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 7 99.20 Very High Very High Very High
Alzheimer's Dementia 11 98.92 Very High Very High Very High
Disease 13 97.60 Very High Very High Very High
Targeted Disruption 5 97.08 Very High Very High Very High
Amyloid Plaque 1 93.52 High High
Toxicity 6 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some nonsteroidal anti-inflammatory drugs has been shown to allosterically modulate the activity of gamma-secretase, the enzymatic complex responsible for the formation of beta-amyloid (Abeta). 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074) is a new gamma-secretase modulator, devoid of anticyclooxygenase (COX) and Notch-interfering activities in vitro.
Regulation (modulate) of gamma-secretase in Notch associated with inflammation, alzheimer's dementia, cinod and abeta
1) Confidence 0.25 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17895400 Disease Relevance 0.57 Pain Relevance 0.18
Some nonsteroidal anti-inflammatory drugs has been shown to allosterically modulate the activity of gamma-secretase, the enzymatic complex responsible for the formation of beta-amyloid (Abeta). 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074) is a new gamma-secretase modulator, devoid of anticyclooxygenase (COX) and Notch-interfering activities in vitro.
Regulation (responsible) of gamma-secretase in Notch associated with inflammation, alzheimer's dementia, cinod and abeta
2) Confidence 0.19 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17895400 Disease Relevance 0.57 Pain Relevance 0.19
The proposed mechanism for this activity is an allosteric modulation of gamma-secretase activity, the enzyme responsible for the formation of amyloid-beta.
Regulation (modulation) of gamma-secretase associated with alzheimer's dementia
3) Confidence 0.06 Published 2004 Journal Expert Opin Investig Drugs Section Abstract Doc Link 15500394 Disease Relevance 1.20 Pain Relevance 0.52
In cultured cells, the decrease in Abeta42 secretion was accompanied by an increase in the Abeta(1-38) isoform, indicating that NSAIDs subtly alter gamma-secretase activity without significantly perturbing other APP processing pathways or Notch cleavage.
Regulation (alter) of gamma-secretase in cleavage associated with cinod and abeta
4) Confidence 0.05 Published 2001 Journal Nature Section Abstract Doc Link 11700559 Disease Relevance 0.45 Pain Relevance 0.79

General Comments

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