INT99260

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.11
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.98
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Defb42) cellular_component (Defb42) biological_process (Defb42)
Anatomy Link Frequency
brain 3
cortex 1
Defb42 (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 8 100.00 Very High Very High Very High
cINOD 30 99.90 Very High Very High Very High
Inflammatory response 2 93.92 High High
Hippocampus 1 84.40 Quite High
Inflammation 2 66.80 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 6 99.76 Very High Very High Very High
Alzheimer's Dementia 15 99.46 Very High Very High Very High
Disease 6 98.24 Very High Very High Very High
INFLAMMATION 11 93.52 High High
Toxicity 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings suggest that NSAIDs directly affect amyloid pathology in the brain by reducing Abeta42 peptide levels independently of COX activity and that this Abeta42-lowering activity could be optimized to selectively target the pathogenic Abeta42 species.
Negative_regulation (reducing) of Abeta42 in brain associated with alzheimer's dementia and cinod
1) Confidence 0.11 Published 2001 Journal Nature Section Abstract Doc Link 11700559 Disease Relevance 0.42 Pain Relevance 0.73
Here we report that the NSAIDs ibuprofen, indomethacin and sulindac sulphide preferentially decrease the highly amyloidogenic Abeta42 peptide (the 42-residue isoform of the amyloid-beta peptide) produced from a variety of cultured cells by as much as 80%.
Negative_regulation (decrease) of Abeta42 associated with alzheimer's dementia and cinod
2) Confidence 0.07 Published 2001 Journal Nature Section Abstract Doc Link 11700559 Disease Relevance 0.44 Pain Relevance 0.74
Post-hoc analysis showed that ibuprofen-dependent reductions of both soluble Abeta and Abeta42 were most marked in entorhinal cortex (p < 0.05).
Negative_regulation (reductions) of Abeta42 in cortex associated with abeta
3) Confidence 0.03 Published 2001 Journal Neurobiol. Aging Section Abstract Doc Link 11755007 Disease Relevance 0.42 Pain Relevance 0.32
Administration of Y-27632, a selective Rock inhibitor, also preferentially lowered brain levels of Abeta42 in a transgenic mouse model of Alzheimer's disease.
Negative_regulation (lowered) of Abeta42 in brain associated with targeted disruption and disease
4) Confidence 0.03 Published 2003 Journal Science Section Abstract Doc Link 14615541 Disease Relevance 0.54 Pain Relevance 0.43
Thus, the Rho-Rock pathway may regulate amyloid precursor protein processing, and a subset of NSAIDs can reduce Abeta42 through inhibition of Rho activity.
Negative_regulation (reduce) of Abeta42 associated with alzheimer's dementia and cinod
5) Confidence 0.02 Published 2003 Journal Science Section Abstract Doc Link 14615541 Disease Relevance 0.52 Pain Relevance 0.42
In a human neuroglioma cell line expressing Swedish mutated form of amyloid precursor protein (H4swe), CHF5074 reduced Abeta42 and Abeta40 secretion, with an IC50 of 3.6 and 18.4 microM, respectively, values consistent with those measured in the brain of the CHF5074-treated Tg2576 mice (6.4 +/- 0.4 microM).
Negative_regulation (reduced) of Abeta42 in brain associated with alzheimer's dementia
6) Confidence 0.01 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17895400 Disease Relevance 0.64 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox