INT99261

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Context Info
Confidence 0.11
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.71
Pain Relevance 2.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Defb42) cellular_component (Defb42) biological_process (Defb42)
Anatomy Link Frequency
brain 2
cleavage 2
Defb42 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 35 99.72 Very High Very High Very High
Abeta 7 98.44 Very High Very High Very High
Hippocampus 1 84.40 Quite High
Inflammatory response 1 73.64 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 16 100.00 Very High Very High Very High
INFLAMMATION 9 99.02 Very High Very High Very High
Disease 6 97.96 Very High Very High Very High
Targeted Disruption 4 84.44 Quite High
Toxicity 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In cultured cells, the decrease in Abeta42 secretion was accompanied by an increase in the Abeta(1-38) isoform, indicating that NSAIDs subtly alter gamma-secretase activity without significantly perturbing other APP processing pathways or Notch cleavage.
Negative_regulation (decrease) of Localization (secretion) of Abeta42 in cleavage associated with cinod and abeta
1) Confidence 0.11 Published 2001 Journal Nature Section Abstract Doc Link 11700559 Disease Relevance 0.47 Pain Relevance 0.81
Recent evidence indicates that some NSAIDs specifically inhibit secretion of the amyloidogenic A beta 42 peptide in cultured cells and mouse models of Alzheimer's disease.
Negative_regulation (inhibit) of Localization (secretion) of beta 42 peptide associated with cinod and disease
2) Confidence 0.04 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12805356 Disease Relevance 0.44 Pain Relevance 0.58
A subset of nonsteroidal anti-inflammatory drugs (NSAIDs) has been shown to preferentially reduce the secretion of the highly amyloidogenic, 42-residue amyloid-beta peptide Abeta42.
Negative_regulation (reduce) of Localization (secretion) of Abeta42 associated with inflammation, alzheimer's dementia and cinod
3) Confidence 0.03 Published 2003 Journal Science Section Abstract Doc Link 14615541 Disease Relevance 0.49 Pain Relevance 0.43
Among non-selective NSAIDs, flurbiprofen and sulindac sulfide concentration-dependently reduced the secretion not only of Abeta42 but also of Abeta40.
Negative_regulation (reduced) of Localization (secretion) of Abeta42 associated with cinod
4) Confidence 0.01 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14690522 Disease Relevance 0.67 Pain Relevance 0.86
In a human neuroglioma cell line expressing Swedish mutated form of amyloid precursor protein (H4swe), CHF5074 reduced Abeta42 and Abeta40 secretion, with an IC50 of 3.6 and 18.4 microM, respectively, values consistent with those measured in the brain of the CHF5074-treated Tg2576 mice (6.4 +/- 0.4 microM).
Negative_regulation (reduced) of Localization (secretion) of Abeta42 in brain associated with alzheimer's dementia
5) Confidence 0.01 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17895400 Disease Relevance 0.64 Pain Relevance 0.16

General Comments

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