INT99270

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Context Info
Confidence 0.08
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 5.74
Pain Relevance 3.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Pvalb)
Anatomy Link Frequency
brainstem 4
dorsal 3
sensory nerve 2
cochlear 1
Pvalb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 27 100.00 Very High Very High Very High
substance P 19 100.00 Very High Very High Very High
Glutamate 11 100.00 Very High Very High Very High
Neuropeptide 10 100.00 Very High Very High Very High
Enkephalin 6 100.00 Very High Very High Very High
Dorsal column 2 98.12 Very High Very High Very High
Thalamus 2 91.40 High High
Neurotransmitter 11 87.76 High High
Limbic system 6 80.80 Quite High
qutenza 8 79.24 Quite High
Disease Link Frequency Relevance Heat
Lissencephaly 4 98.48 Very High Very High Very High
Infantile Spasms 26 97.96 Very High Very High Very High
Brain Hypoxia-ischemia 8 97.32 Very High Very High Very High
Syndrome 20 96.48 Very High Very High Very High
Gliosis 2 96.00 Very High Very High Very High
Cough 72 95.00 High High
Stress 2 82.96 Quite High
Asphyxia 2 82.52 Quite High
Dystonia 4 75.12 Quite High
Freckles 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, we reported the reduced expression of tyrosine hydroxylase, methionine enkephalin and parvalbumin in the brainstem in autopsy cases of lissencephaly and sequels of HIE manifested as WS/LGS, regardless of the cerebral changes.
Negative_regulation (reported) of Gene_expression (expression) of parvalbumin in brainstem associated with brain hypoxia-ischemia, medulla, infantile spasms, syndrome, enkephalin and lissencephaly
1) Confidence 0.08 Published 2001 Journal Brain Dev. Section Abstract Doc Link 11701247 Disease Relevance 2.13 Pain Relevance 0.56
Recently, we reported the reduced expression of tyrosine hydroxylase, methionine enkephalin and parvalbumin in the brainstem in autopsy cases of lissencephaly and sequels of HIE manifested as WS/LGS, regardless of the cerebral changes.
Negative_regulation (reduced) of Gene_expression (expression) of parvalbumin in brainstem associated with brain hypoxia-ischemia, medulla, infantile spasms, syndrome, enkephalin and lissencephaly
2) Confidence 0.08 Published 2001 Journal Brain Dev. Section Abstract Doc Link 11701247 Disease Relevance 2.12 Pain Relevance 0.56
Immunohistochemical studies of other sensory nerve populations have successfully used the expression of proton pump isozymes, vesicular glutamate transporters (vGluts; a marker for glutamatergic neurons), neuropeptides and calcium binding proteins (such as calretinin, calbindin and parvalbumin) as useful markers for characterizing sensory nerve subtypes.
Negative_regulation (used) of Gene_expression (expression) of parvalbumin in sensory nerve associated with glutamate and neuropeptide
3) Confidence 0.04 Published 2008 Journal Cough Section Body Doc Link PMC2586627 Disease Relevance 0.45 Pain Relevance 0.50
Nevertheless, the expressions of parvalbumin, substance P, and methionine-enkephalin in the brainstem were comparatively preserved; the exception being reduced immunoreactivity for them in the cochlear and dorsal column nuclei in 3 cases.
Negative_regulation (reduced) of Gene_expression (expressions) of parvalbumin in dorsal associated with medulla, enkephalin, dorsal column and substance p
4) Confidence 0.03 Published 2004 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 15535132 Disease Relevance 0.52 Pain Relevance 0.76
Nevertheless, the expressions of parvalbumin, substance P, and methionine-enkephalin in the brainstem were comparatively preserved; the exception being reduced immunoreactivity for them in the cochlear and dorsal column nuclei in 3 cases.
Negative_regulation (reduced) of in cochlear Gene_expression (expressions) of parvalbumin in dorsal associated with medulla, enkephalin, dorsal column and substance p
5) Confidence 0.01 Published 2004 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 15535132 Disease Relevance 0.52 Pain Relevance 0.76

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