INT99287

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Context Info
Confidence 0.35
First Reported 2001
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.87
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (GOLPH3) mitochondrion (GOLPH3) Golgi apparatus (GOLPH3)
cytoplasm (GOLPH3) cytosol (GOLPH3) cell proliferation (GOLPH3)
Anatomy Link Frequency
blood 1
GOLPH3 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 56 100.00 Very High Very High Very High
chemokine 4 99.60 Very High Very High Very High
Migraine 135 96.12 Very High Very High Very High
Pain 17 57.28 Quite High
opioid receptor 1 52.24 Quite High
Opioid 2 28.56 Quite Low
antagonist 3 25.00 Low Low
agonist 2 25.00 Low Low
mu opioid receptor 1 25.00 Low Low
depression 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Headache 188 100.00 Very High Very High Very High
Hypertension 106 100.00 Very High Very High Very High
Adhesions 1 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 99.92 Very High Very High Very High
Bacillus Anthracis Infection 17 98.28 Very High Very High Very High
Cancer 3 94.92 High High
Pain 17 75.60 Quite High
Poisoning 19 73.04 Quite High
Death 12 71.72 Quite High
Pressure And Volume Under Development 6 65.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both the chemokine SDF-1alpha and the human immunodeficiency virus-1 (HIV-1) coat protein gp120 can bind to CXCR4 chemokine receptors but with different signaling consequences.
coat protein Binding (bind) of associated with chemokine and acquired immune deficiency syndrome or hiv infection
1) Confidence 0.35 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15014135 Disease Relevance 0.27 Pain Relevance 0.16
Physicians also identified MIDAS scores they associated with different degrees of disability and with the urgency to prescribe an effective treatment during the first consultation.
MIDAS Binding (associated) of
2) Confidence 0.31 Published 2001 Journal Headache Section Body Doc Link 11703471 Disease Relevance 0.08 Pain Relevance 0
Although explaining only 2.1% of the variance, age was significantly associated with MIDAS scores, with those under 25 years demonstrating higher MIDAS scores than other age groups.
MIDAS Binding (associated) of
3) Confidence 0.31 Published 2003 Journal Headache Section Body Doc Link 12603645 Disease Relevance 0 Pain Relevance 0
MTSM scores showed expected associations with MSFB scores (-0.301; P < 0.01), MIDAS (-0.267; P < 0.01), general health (0.253; P < 0.05), mental health (0.217; P < 0.05), and vitality subscales of SF-36 (0.214; P < 0.05).
MIDAS Binding (associations) of
4) Confidence 0.15 Published 2008 Journal Value Health Section Body Doc Link 18494756 Disease Relevance 0.06 Pain Relevance 0
This might be a best evidence approach in patients with sustained hypertension diagnosed by ABPM but, it might be a high-risk approach in cases with white coat hypertension, not recognized by conventional office blood pressure measurement.


coat hypertension Spec (might) Binding (recognized) of in blood associated with hypertension
5) Confidence 0.03 Published 2005 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC1087862 Disease Relevance 0.85 Pain Relevance 0
MIDAS has five questions assessing headache-related disability over the preceding 3 months, and can be summarized in a single question: “How many days in the last 3 months were you at least 50% disabled due to migraine at work, home, school, or recreational activities?”
MIDAS Binding (summarized) of associated with migraine and headache
6) Confidence 0.03 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646645 Disease Relevance 0.79 Pain Relevance 0.68
PA interacts with both receptors through a common von Willebrand factor A/integrin-like inserted (I) domain that contains a metal ion adhesion site (MIDAS) with five metal ion coordinating residues [30].
MIDAS Binding (interacts) of associated with adhesions
7) Confidence 0.02 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1617126 Disease Relevance 0.82 Pain Relevance 0

General Comments

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