INT99291

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Context Info
Confidence 0.46
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.16
Pain Relevance 3.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) plasma membrane (Slc6a4)
Anatomy Link Frequency
aorta 2
B-cell 1
osteoblasts 1
midbrain 1
Slc6a4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Raphe 8 99.98 Very High Very High Very High
midbrain 7 99.68 Very High Very High Very High
fluoxetine 50 99.32 Very High Very High Very High
Eae 24 98.92 Very High Very High Very High
antidepressant 122 98.16 Very High Very High Very High
Serotonin 15 94.04 High High
Hippocampus 18 91.64 High High
medulla 1 87.76 High High
depression 85 85.92 High High
amygdala 8 84.24 Quite High
Disease Link Frequency Relevance Heat
Osteoporosis 2 98.62 Very High Very High Very High
Chronic Lymphoid Leukemia 1 96.96 Very High Very High Very High
Mantle-cell Lymphoma 1 95.72 Very High Very High Very High
Follicular Lymphoma 1 94.84 High High
Lymphatic System Cancer 2 93.60 High High
Targeted Disruption 27 90.56 High High
Depression 92 85.92 High High
Urological Neuroanatomy 4 83.00 Quite High
Shock 3 80.56 Quite High
Respiratory Tract Infection 3 71.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In aorta and mesenteric resistance arteries, real time RT-PCR and western analyses indicated the presence of 5-HTT mRNA and a 74 kDa 5-HTT protein.
Transcription (presence) of 5-HTT in aorta
1) Confidence 0.46 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15167270 Disease Relevance 0 Pain Relevance 0.04
In aorta and mesenteric resistance arteries, real time RT-PCR and western analyses indicated the presence of 5-HTT mRNA and a 74 kDa 5-HTT protein.
Transcription (presence) of 5-HTT in aorta
2) Confidence 0.46 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15167270 Disease Relevance 0 Pain Relevance 0.04
Here we detail SLC6A4 transcript (Q-PCR) and protein (FACS) expression in primary cells from patients with: chronic lymphocytic leukaemia; mantle cell lymphoma; follicular lymphoma; Burkitt's lymphoma; and diffuse large B-cell lymphoma.
Transcription (transcript) of SLC6A4 in B-cell associated with mantle-cell lymphoma, chronic lymphoid leukemia, lymphatic system cancer and follicular lymphoma
3) Confidence 0.41 Published 2010 Journal Leuk. Res. Section Abstract Doc Link 20363025 Disease Relevance 0.47 Pain Relevance 0.35
There were no changes in the expression of 5-HTT mRNA, suggesting these effects were not due to changes in gene transcription.
Transcription (expression) of 5-HTT
4) Confidence 0.27 Published 2009 Journal Neuropsychopharmacology Section Abstract Doc Link 18496518 Disease Relevance 0 Pain Relevance 0.89
A significant induction of TPH2 and 5-HT transporter (5-HTT) mRNAs was detected in the midbrain of untreated rats 24 h after the swim test.
Transcription (detected) of 5-HTT in midbrain associated with midbrain
5) Confidence 0.26 Published 2007 Journal Neuroscience Section Abstract Doc Link 17950541 Disease Relevance 0 Pain Relevance 1.10
Primary cultures of rat osteoblasts (rOB) and a variety of clonal osteoblastic cell lines, including ROS 17/2.8, UMR 106-H5, and Py1a, showed mRNA expression for 5-HTT as well as the 5-HT(1A), 5-HT(1D), 5-HT(2A), and 5-HT(2B) receptors by reverse transcription-polymerase chain reaction (RT-PCR) analysis.
Transcription (expression) of 5-HTT in osteoblasts associated with osteoporosis
6) Confidence 0.23 Published 2001 Journal Bone Section Abstract Doc Link 11704501 Disease Relevance 0.23 Pain Relevance 0.35
Maternal separation induced increased immobility in rat FST was mediated by decreased hippocampal 5-HT and raphe expression of 5-HTT mRNA [162].
Transcription (expression) of 5-HTT associated with eae and raphe
7) Confidence 0.07 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.46 Pain Relevance 0.52

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