INT99325

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.55
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pdha1) oxidoreductase activity (Pdha1)
Anatomy Link Frequency
pyramidal cell 1
pore 1
Pdha1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 14 100.00 Very High Very High Very High
Migraine 3 100.00 Very High Very High Very High
Pyramidal cell 59 99.68 Very High Very High Very High
Hippocampus 13 98.36 Very High Very High Very High
interstitial cystitis 41 94.88 High High
anesthesia 14 94.08 High High
ketamine 75 80.56 Quite High
Calcium channel 1 75.00 Quite High
Glutamate 1 45.12 Quite Low
Limbic system 4 44.48 Quite Low
Disease Link Frequency Relevance Heat
Migraine With Aura 1 100.00 Very High Very High Very High
Cystitis 70 97.68 Very High Very High Very High
Interstitial Cystitis 41 94.88 High High
Lactic Acidosis 3 94.88 High High
Death 3 92.00 High High
Targeted Disruption 3 90.56 High High
Headache 2 75.00 Quite High
Unconsciousness 14 63.08 Quite High
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mosaic mice were interbred to increase the degree of mosaicism for the Pdha1(Deltaex8) allele in the subsequent generation, resulting in a significantly smaller litter size (54% reduction).
Positive_regulation (increase) of Pdha1
1) Confidence 0.49 Published 2001 Journal Mol. Genet. Metab. Section Abstract Doc Link 11708858 Disease Relevance 0.13 Pain Relevance 0.06
Inactivation of the murine pyruvate dehydrogenase (Pdha1) gene and its effect on early embryonic development.
Positive_regulation (Inactivation) of Pdha1
2) Confidence 0.49 Published 2001 Journal Mol. Genet. Metab. Section Title Doc Link 11708858 Disease Relevance 0.19 Pain Relevance 0.09
Two loxP sequences were introduced into intronic sequences flanking exon 8 to generate the Pdha1(flox8) allele.
Positive_regulation (generate) of Pdha1
3) Confidence 0.45 Published 2001 Journal Mol. Genet. Metab. Section Abstract Doc Link 11708858 Disease Relevance 0.17 Pain Relevance 0.09
Familial hemiplegic migraine type 1 (FHM1) is caused by missense mutations in the CACNA1A gene that encodes the alpha1A pore-forming subunit of Ca(V)2.1 Ca(2+) channels.
Positive_regulation (caused) of Familial hemiplegic migraine type 1 in pore associated with migraine with aura and migraine
4) Confidence 0.09 Published 2010 Journal Proteomics Section Abstract Doc Link 20391530 Disease Relevance 0.43 Pain Relevance 0.21
Serum levels of these CXCR3 ligands and local T helper type 1 (Th1) cytokines were also increased.
Positive_regulation (increased) of helper type 1 associated with cytokine
5) Confidence 0.02 Published 2008 Journal J Immune Based Ther Vaccines Section Abstract Doc Link PMC2583981 Disease Relevance 0.57 Pain Relevance 0.34
Type-1 (basket cell), type-2 (bistratified cell) and type-3 (chandelier cell) are positioned in the pyramidal cell body layer in the hippocampus CA1 subregion.
Positive_regulation (positioned) of Type-1 in pyramidal cell associated with pyramidal cell and hippocampus
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999569 Disease Relevance 0.06 Pain Relevance 0.43

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox