INT99327

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.24
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PNKD) nucleus (PNKD) cytoplasm (PNKD)
Anatomy Link Frequency
peripheral nerves 1
hip joints 1
PNKD (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 1 98.28 Very High Very High Very High
diabetic neuropathy 4 98.12 Very High Very High Very High
Sciatic nerve 2 96.68 Very High Very High Very High
Pain 1 87.60 High High
allodynia 1 71.08 Quite High
Thermal hyperalgesia 1 70.08 Quite High
spinal inflammation 2 50.00 Quite Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lactic Acidosis 1 99.08 Very High Very High Very High
Diabetic Neuropathy 3 98.12 Very High Very High Very High
Death 1 96.20 Very High Very High Very High
Stress 5 90.16 High High
Pain 1 87.60 High High
Nociception 1 72.12 Quite High
Neuropathic Pain 1 71.08 Quite High
Low Back Pain 2 70.12 Quite High
Hyperalgesia 1 70.08 Quite High
Peripheral Neuropathy 1 63.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A deficiency of pyruvate dehydrogenase complex (PDC) in humans results in lactic acidosis and neurological dysfunction that frequently results in death during infancy.
Negative_regulation (deficiency) of PDC associated with anesthesia, lactic acidosis and death
1) Confidence 0.57 Published 2001 Journal Mol. Genet. Metab. Section Abstract Doc Link 11708858 Disease Relevance 0.20 Pain Relevance 0.10
After treatment, 12 patients showed decreased ASspiMRI-a score and less affection in the sacroiliac and hip joints.
Negative_regulation (decreased) of MRI in hip joints
2) Confidence 0.42 Published 2007 Journal Radiologia Section Body Doc Link 17524334 Disease Relevance 0.07 Pain Relevance 0
Thus, it can be concluded that treatment with the combination of a PDC and PARP inhibitor attenuates alteration in peripheral nerves in diabetic neuropathy (DN).
Negative_regulation (inhibitor) of PDC in peripheral nerves associated with diabetic neuropathy
3) Confidence 0.41 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19900402 Disease Relevance 0.97 Pain Relevance 0.46

General Comments

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