INT99329

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Context Info
Confidence 0.37
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.45
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrna4) transport (Chrna4) plasma membrane (Chrna4)
neurological system process (Chrna4)
Chrna4 (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 2 98.64 Very High Very High Very High
Analgesic 5 98.30 Very High Very High Very High
Nicotine 17 83.04 Quite High
Peripheral nervous system 1 81.84 Quite High
agonist 7 80.96 Quite High
Thalamus 1 72.32 Quite High
Hippocampus 15 65.76 Quite High
antinociception 2 32.72 Quite Low
Pain 1 25.00 Low Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 1 98.92 Very High Very High Very High
Targeted Disruption 27 97.84 Very High Very High Very High
Urological Neuroanatomy 1 74.20 Quite High
Toxicity 1 41.36 Quite Low
Schizophrenia 5 27.20 Quite Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 1 5.00 Very Low Very Low Very Low
Anxiety Disorder 1 5.00 Very Low Very Low Very Low
Infection 1 5.00 Very Low Very Low Very Low
Lifespan 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study examines the hypothesis for the first time that the neonicotinoid insecticides and their imine metabolites and analogs display analgesic (antinociceptive) activity or adverse toxic effects associated with their action on binding to the alpha 4 beta 2 nicotinic acetylcholine receptor (AChR) subtype.
alpha 4 beta 2 nicotinic acetylcholine receptor Binding (binding) of associated with analgesic and antinociceptive
1) Confidence 0.37 Published 2001 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 11708903 Disease Relevance 0 Pain Relevance 0.49
2 nAChR-mediated processing of sensory information (see Schreiber et al., 2002; Champtiaux and Changeux, 2004), though enhanced startle responding in our eyeblink tasks may be associated with previous findings of hyperactivity in ?
nAChR Binding (associated) of associated with attention deficit hyperactivity disorder
2) Confidence 0.10 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2958052 Disease Relevance 0.45 Pain Relevance 0.07
Individual nAChR channels have unique biological functions that are determined by the pentameric combination of 11 distinct subunits: ?
nAChR Binding (Individual) of
3) Confidence 0.03 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.04

General Comments

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