INT99341

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.15
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 1
medial entorhinal cortex 1
globus pallidus 1
Slc6a12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 36 100.00 Very High Very High Very High
GABAergic 4 94.92 High High
pregabalin 8 94.24 High High
Gabapentin 9 93.64 High High
Neuropathic pain 5 90.96 High High
Glutamate 107 86.64 High High
antagonist 8 84.88 Quite High
Action potential 5 81.36 Quite High
tetrodotoxin 3 77.76 Quite High
Kinase C 1 77.20 Quite High
Disease Link Frequency Relevance Heat
Epilepsy 101 91.48 High High
Neuropathic Pain 6 90.96 High High
Syndrome 140 85.72 High High
Neurological Disease 1 77.12 Quite High
Hyperalgesia 5 75.08 Quite High
Convulsion 127 74.72 Quite High
Psychosis 1 55.72 Quite High
Death 4 51.60 Quite High
Apoptosis 1 47.20 Quite Low
Cognitive Disorder 6 44.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To elucidate the cellular action of tiagabine, an inhibitor of GAT-1 GABA transporter, in the globus pallidus, whole-cell patch-clamp recordings were made from rat globus pallidus neurons in the acutely prepared brain slice.
Negative_regulation (inhibitor) of GAT-1 in globus pallidus associated with gaba
1) Confidence 0.57 Published 2003 Journal Exp Brain Res Section Abstract Doc Link 12879169 Disease Relevance 0 Pain Relevance 0.33
This increase in uptake was correlated with a redistribution of GAT1 protein from intracellular locations to the plasma membrane.
Negative_regulation (redistribution) of GAT1 in plasma
2) Confidence 0.43 Published 2001 Journal Biochem. Soc. Trans. Section Abstract Doc Link 11709066 Disease Relevance 0.22 Pain Relevance 0.89
The ability of two GABA transport inhibitors to modulate inhibitory tone via inhibition of mGAT1 (tiagabine) or mGAT2/BGT-1 (N-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-4-(methylamino-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol), also known as EF1502) was evaluated using an in vitro model of spontaneous interictal-like bursting (SB).
Negative_regulation (inhibition) of BGT-1 associated with gaba
3) Confidence 0.41 Published 2008 Journal Epilepsy Res. Section Abstract Doc Link 18262393 Disease Relevance 0.18 Pain Relevance 0.27
Inhibition of the betaine-GABA transporter (mGAT2/BGT-1) modulates spontaneous electrographic bursting in the medial entorhinal cortex (mEC).
Negative_regulation (Inhibition) of betaine-GABA in medial entorhinal cortex associated with gaba
4) Confidence 0.34 Published 2008 Journal Epilepsy Res. Section Title Doc Link 18262393 Disease Relevance 0.18 Pain Relevance 0.27
TGB is a selective competitive inhibitor of GAT1 that prevents GABA uptake.
Negative_regulation (inhibitor) of GAT1 associated with gaba
5) Confidence 0.09 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646636 Disease Relevance 0.56 Pain Relevance 0.20
These currents were also insensitive to the GABA transporter inhibitor SKF-89976A (25 ?
Negative_regulation (inhibitor) of GABA transporter associated with gaba
6) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2713213 Disease Relevance 0 Pain Relevance 0.31

General Comments

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