INT99375

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Context Info
Confidence 0.61
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.63
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (APP) extracellular matrix organization (APP) DNA binding (APP)
cytoplasm (APP) cytosol (APP) extracellular region (APP)
APP (Homo sapiens)
Pain Link Frequency Relevance Heat
Abeta 3 100.00 Very High Very High Very High
aspirin 5 99.78 Very High Very High Very High
palliative 1 97.36 Very High Very High Very High
cINOD 5 92.16 High High
Arthritis 3 89.64 High High
Potency 1 69.76 Quite High
COX2 1 25.00 Low Low
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 9 100.00 Very High Very High Very High
Disease 9 98.12 Very High Very High Very High
Arthritis 3 89.64 High High
INFLAMMATION 3 87.84 High High
Amyloid Plaque 1 70.76 Quite High
Increased Venous Pressure Under Development 1 42.64 Quite Low
Cancer 1 5.00 Very Low Very Low Very Low
Cardiovascular Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aspirin prevented enhanced Abeta aggregation by aluminum, an environmental risk factor for AD.
Positive_regulation (enhanced) of Abeta Binding (aggregation) of associated with aspirin, disease and abeta
1) Confidence 0.61 Published 2001 Journal Neuroreport Section Abstract Doc Link 11711868 Disease Relevance 0.86 Pain Relevance 0.70
The drug-induced decrease of membrane fluidity correlated with an increased association of APP and its beta-site cleaving enzyme BACE1 with detergent-resistant membranes (DRMs), which represent membrane clusters of substantial rigidity.
Positive_regulation (increased) of APP Binding (association) of
2) Confidence 0.49 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17395689 Disease Relevance 0.50 Pain Relevance 0
The interest for acetylcholinesterase as a target for the palliative treatment of Alzheimer's disease has been renewed in the last years owing to the evidences that support the role of this enzyme in accelerating the aggregation and deposition of the beta-amyloid peptide.
Positive_regulation (accelerating) of beta-amyloid peptide Binding (aggregation) of associated with alzheimer's dementia, disease and palliative
3) Confidence 0.11 Published 2004 Journal Curr. Pharm. Des. Section Abstract Doc Link 15544503 Disease Relevance 0.27 Pain Relevance 0.13

General Comments

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