INT99389

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Context Info
Confidence 0.45
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.97
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctnnb1) enzyme binding (Ctnnb1) DNA binding (Ctnnb1)
protein complex (Ctnnb1) cytoplasm (Ctnnb1) cell proliferation (Ctnnb1)
Anatomy Link Frequency
colon 2
Ctnnb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 13 99.42 Very High Very High Very High
Inflammation 20 97.52 Very High Very High Very High
COX-2 inhibitor 1 79.20 Quite High
aspirin 8 75.00 Quite High
COX2 1 25.00 Low Low
cytokine 20 5.00 Very Low Very Low Very Low
fibrosis 7 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 10 99.68 Very High Very High Very High
Hepatocellular Cancer 76 99.38 Very High Very High Very High
INFLAMMATION 31 99.32 Very High Very High Very High
Colorectal Cancer 5 99.00 Very High Very High Very High
Cancer 25 90.76 High High
Apoptosis 7 88.84 High High
Cirrhosis 28 74.48 Quite High
Stress 4 68.88 Quite High
Hepatitis C Virus Infection 72 50.00 Quite Low
Body Weight 1 38.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We report that nabumetone decreased uninvolved intestinal mucosal beta-catenin levels in the MIN mouse with a concomitant increase in glycogen synthase kinase (GSK)-3beta levels, an enzyme that targets beta-catenin for destruction.
Negative_regulation (decreased) of beta-catenin
1) Confidence 0.45 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15617833 Disease Relevance 0.27 Pain Relevance 0.12
In conclusion, we demonstrate that the differential mechanisms for beta-catenin suppression may be determined, at least partly, by GSK-3beta.
Negative_regulation (suppression) of beta-catenin
2) Confidence 0.45 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15617833 Disease Relevance 0.23 Pain Relevance 0.11
Inhibition of beta-catenin translocation in rodent colorectal tumors: a novel explanation for the protective effect of nonsteroidal antiinflammatory drugs in colorectal cancer.
Negative_regulation (Inhibition) of beta-catenin associated with colorectal cancer and inflammation
3) Confidence 0.43 Published 2001 Journal Dig. Dis. Sci. Section Title Doc Link 11713928 Disease Relevance 1.18 Pain Relevance 0.06
However, in the azoxymethane-treated rat, where beta-catenin is frequently rendered GSK-3beta-insensitive, nabumetone failed to alter beta-catenin levels but did decrease beta-catenin nuclear localization and transcriptional activity as gauged by cyclin D1.
Neg (failed) Negative_regulation (decrease) of beta-catenin
4) Confidence 0.33 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15617833 Disease Relevance 0.24 Pain Relevance 0.12
The mechanisms through which beta-catenin signaling is inhibited during colorectal cancer chemoprevention by nonsteroidal anti-inflammatory agents is incompletely understood.
Negative_regulation (inhibited) of beta-catenin associated with inflammation and colon cancer
5) Confidence 0.33 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15617833 Disease Relevance 0.27 Pain Relevance 0.12
The nonsteroidal anti-inflammatory drug, nabumetone, differentially inhibits beta-catenin signaling in the MIN mouse and azoxymethane-treated rat models of colon carcinogenesis.
Negative_regulation (inhibits) of beta-catenin in colon associated with inflammation and cinod
6) Confidence 0.33 Published 2005 Journal Cancer Lett. Section Title Doc Link 15617833 Disease Relevance 0.28 Pain Relevance 0.15
The results of this study provide strong evidence that NO-NSAIDs possess strong inhibitory effect against colon carcinogenesis; their effect is associated with suppression of COX and NOS-2 activities and beta-catenin levels in colon tumors.
Negative_regulation (suppression) of beta-catenin in colon associated with colon cancer and cinod
7) Confidence 0.21 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16818512 Disease Relevance 0.50 Pain Relevance 0.41
Recent evidence suggested that cyclooxygenase-2 (COX-2)-derived prostaglandin PGE(2) and Wnt/beta-catenin signaling pathways are implicated in hepatocarcinogenesis and reported that omega-3 polyunsaturated fatty acids (PUFA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) inhibited HCC growth through simultaneously inhibition of COX-2 and beta-catenin [74].
Negative_regulation (inhibition) of beta-catenin associated with hepatocellular cancer
8) Confidence 0.01 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 1.00 Pain Relevance 0.12

General Comments

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