INT99391

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Context Info
Confidence 0.80
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 5.84
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctnnb1) enzyme binding (Ctnnb1) DNA binding (Ctnnb1)
protein complex (Ctnnb1) cytoplasm (Ctnnb1) cell proliferation (Ctnnb1)
Anatomy Link Frequency
spinal cord 1
epithelium 1
Ctnnb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 2 98.76 Very High Very High Very High
withdrawal 3 98.48 Very High Very High Very High
Spinal cord 2 97.76 Very High Very High Very High
Inflammation 25 96.68 Very High Very High Very High
antagonist 2 95.48 Very High Very High Very High
cINOD 10 92.92 High High
antidepressant 2 92.32 High High
Hippocampus 22 60.88 Quite High
dexamethasone 7 50.36 Quite High
cytokine 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aberrant Crypt Foci 28 99.84 Very High Very High Very High
Colorectal Cancer 5 99.56 Very High Very High Very High
Cancer 13 98.88 Very High Very High Very High
Opiate Addiction 1 98.76 Very High Very High Very High
INFLAMMATION 38 96.68 Very High Very High Very High
Rheumatoid Arthritis 6 95.80 Very High Very High Very High
Nociception 1 95.04 Very High Very High Very High
Apoptosis 22 89.40 High High
Pneumococcal Meningitis 21 83.04 Quite High
Colitis 2 82.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of beta-catenin translocation in rodent colorectal tumors: a novel explanation for the protective effect of nonsteroidal antiinflammatory drugs in colorectal cancer.
Localization (translocation) of beta-catenin associated with colorectal cancer and inflammation
1) Confidence 0.80 Published 2001 Journal Dig. Dis. Sci. Section Title Doc Link 11713928 Disease Relevance 1.19 Pain Relevance 0.06
In most of the ACF (91%), beta-catenin was localized at the cell membrane like in normal colon epithelium.
Localization (localized) of beta-catenin in epithelium associated with aberrant crypt foci
2) Confidence 0.67 Published 2002 Journal Int. J. Mol. Med. Section Abstract Doc Link 11891526 Disease Relevance 1.96 Pain Relevance 0.36
Increased prostaglandin E2 release and activated Akt/beta-catenin signaling pathway occur after opioid withdrawal in rat spinal cord.
Localization (release) of beta-catenin in spinal cord associated with withdrawal, opioid and spinal cord
3) Confidence 0.61 Published 2006 Journal Anesthesiology Section Title Doc Link 16810007 Disease Relevance 0.19 Pain Relevance 0.38
Furthermore, we examined the expression and the localization of beta-catenin protein, and the proliferating cell nuclear antigen (PCNA)-labeling index (LI) in ACF and cancer.
Localization (localization) of beta-catenin associated with aberrant crypt foci and cancer
4) Confidence 0.58 Published 2002 Journal Int. J. Mol. Med. Section Abstract Doc Link 11891526 Disease Relevance 1.74 Pain Relevance 0.41
However, in the azoxymethane-treated rat, where beta-catenin is frequently rendered GSK-3beta-insensitive, nabumetone failed to alter beta-catenin levels but did decrease beta-catenin nuclear localization and transcriptional activity as gauged by cyclin D1.
Localization (localization) of beta-catenin
5) Confidence 0.55 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15617833 Disease Relevance 0.24 Pain Relevance 0.12
However, in the azoxymethane-treated rat, where beta-catenin is frequently rendered GSK-3beta-insensitive, nabumetone failed to alter beta-catenin levels but did decrease beta-catenin nuclear localization and transcriptional activity as gauged by cyclin D1.
Localization (localization) of beta-catenin
6) Confidence 0.55 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15617833 Disease Relevance 0.24 Pain Relevance 0.12
In the same line of evidence it was demonstrated that the chronic administration of the dual reuptake inhibitor venlafaxine induces the nuclear translocation of beta-catenin most likely by an inhibition of GSK3?
Localization (translocation) of beta-catenin
7) Confidence 0.09 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.28 Pain Relevance 0.17

General Comments

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