INT99410

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Context Info
Confidence 0.45
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 2.20
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (UGT1A1) endoplasmic reticulum (UGT1A1) enzyme binding (UGT1A1)
Anatomy Link Frequency
hepatocytes 3
liver 1
small intestine 1
UGT1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 26 99.96 Very High Very High Very High
Buprenorphine 12 99.12 Very High Very High Very High
ischemia 1 87.36 High High
abdominal pain 1 70.80 Quite High
Pain 1 68.64 Quite High
Morphine 7 55.20 Quite High
Bile 73 49.68 Quite Low
Inflammation 17 40.96 Quite Low
agonist 91 5.00 Very Low Very Low Very Low
Kinase C 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 21 99.30 Very High Very High Very High
Targeted Disruption 14 97.44 Very High Very High Very High
Gallstones 29 97.28 Very High Very High Very High
Choledocholithiasis 4 93.68 High High
Thalassemia 3 92.32 High High
Sickle Cell Anemia 6 88.68 High High
Cv Unclassified Under Development 1 87.36 High High
Intrahepatic Cholestasis 3 83.16 Quite High
Lithiasis 3 80.88 Quite High
Poisoning 1 76.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although most UGTs could glucuronidate APAP, UGT1A1, UGT1A6, and UGT1A9 were most active.
Positive_regulation (active) of UGT1A1 associated with paracetamol
1) Confidence 0.45 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11714888 Disease Relevance 0.08 Pain Relevance 0.86
The UGT1A1 promoter (TA)(6/7)TAA mutation (UGT1A1*28) resulted in a 28% decrease of BUP glucuronidation V(max) in pooled HLMs but was not statistically associated with glucuronidation rate in 52 individual HLMs.
Neg (not) Positive_regulation (resulted) of UGT1A1 associated with buprenorphine
2) Confidence 0.43 Published 2010 Journal Drug Metab. Dispos. Section Abstract Doc Link 19841060 Disease Relevance 0 Pain Relevance 0.98
In a study using antipeptide antibodies to examine the effects of drug treatments on rat hepatic microsomal UGT levels, clofibrate treatment was found to increase the immunoreactive protein levels of UGT1A1 and UGT1A5 (termed UGT1B1 and UGT1B5 in that study) along with bilirubin UGT activity [110].
Positive_regulation (increase) of UGT1A1
3) Confidence 0.27 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0 Pain Relevance 0.06
activators produced modest increases in hepatic UGT1A1 and UGT1A3 mRNA levels [122].
Positive_regulation (increases) of UGT1A1
4) Confidence 0.27 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0 Pain Relevance 0
In a recent study by Senekeo-Effenberger et al. [125], Wy-14,643 treatment of primary cultured human hepatocytes increased the levels of UGT1A1, UGT1A3, UGT1A4, and UGT1A6, but not UGT1A9, mRNAs.
Positive_regulation (increased) of UGT1A1 in hepatocytes
5) Confidence 0.25 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.09 Pain Relevance 0
In the same study, experiments conducted with transgenic mice engineered to express the complete human UGT1 gene locus demonstrated that oral Wy-14,643 treatment resulted in prominent induction of human UGT1A1 and UGT1A6, and observable induction of UGT1A4, immunoreactive protein content in liver microsomes.
Positive_regulation (induction) of UGT1A1 in liver associated with targeted disruption
6) Confidence 0.25 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.10 Pain Relevance 0
In small intestine, Wy-14,643 treatment produced induction of UGT1A1 and UGT1A4, but not UGT1A6, while in kidney only UGT1A6 was induced [125].
Positive_regulation (induction) of UGT1A1 in small intestine
7) Confidence 0.25 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.28 Pain Relevance 0
In addition, clofibric acid treatment of primary cultured rat hepatocytes has been reported to increase the amount of UGT1A1 protein by western blot analysis [119] and the amount of UGT1A1 mRNA by microarray analysis [123].
Positive_regulation (increase) of UGT1A1 protein in hepatocytes
8) Confidence 0.25 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0 Pain Relevance 0
At the mRNA level in liver, very strong (>100-fold) induction of UGT1A1 and UGT1A3, significant (~3- to 4-fold) induction of UGT1A4 and UGT1A6, and no induction of UGT1A9 were seen, in general agreement with the above-described effects in the human hepatocyte cultures [125].
Positive_regulation (induction) of UGT1A1 in hepatocyte
9) Confidence 0.25 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.09 Pain Relevance 0
The highest prevalence of these complications occurs in patients with Gilbert's syndrome because of the combined effect of increased bilirubin production and reduced bilirubin-diphosphate-glucuronosyltransferase (UGT1-A1) enzyme activity [7,8].
Positive_regulation (increased) of bilirubin-diphosphate-glucuronosyltransferase associated with syndrome
10) Confidence 0.06 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964605 Disease Relevance 1.57 Pain Relevance 0.18

General Comments

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