INT99413

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Context Info
Confidence 0.09
First Reported 2001
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (PPFIA4) cytoplasm (PPFIA4)
Anatomy Link Frequency
autonomic 1
PPFIA4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 22 98.08 Very High Very High Very High
local anesthetic 9 97.00 Very High Very High Very High
Potency 4 82.64 Quite High
lidocaine 1 53.44 Quite High
agonist 17 10.00 Low Low
addiction 3 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The calculated Van der Waals repulsions with alpha4-beta2 and alpha3-beta2 nAChRs remain small, and within the accuracy limit of Van der Waals energy prediction (the otherwise negligible displacement of an atom by a tenth of an Angstrom may result in several kcal/mol energy difference).
Gene_expression (repulsions) of alpha4
1) Confidence 0.09 Published 2002 Journal BMC Struct Biol Section Body Doc Link PMC65631 Disease Relevance 0 Pain Relevance 0.12
The current studies established effects of LAs on function of four human nAChR subtypes: naturally expressed muscle-type (alpha1*-nAChR) or autonomic (alpha3beta4*-nAChR) nAChR, or heterologously expressed nAChR containing alpha4 with either beta2- or beta4-subunits (alpha4beta2- or alpha4beta4-nAChR).
Gene_expression (expressed) of alpha4 in autonomic associated with local anesthetic
2) Confidence 0.04 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11714893 Disease Relevance 0 Pain Relevance 0.70

General Comments

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