INT99416

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Context Info
Confidence 0.34
First Reported 2001
Last Reported 2001
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.64
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Bcar1) plasma membrane (Bcar1) cytoplasm (Bcar1)
Bcar1 (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 20 99.76 Very High Very High Very High
antinociception 12 98.84 Very High Very High Very High
analgesia 2 91.40 High High
Morphine 2 69.68 Quite High
Analgesic 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Nociception 10 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
L-NG-nitroarginine methyl ester (CAS 51298-62-5), a NO synthase inhibitor, at 75 mg/kg, s.c. produced antinociception and significantly increased the antinociceptive effect of pyridoxine (63.7 +/- 1.2%).
Negative_regulation (inhibitor) of CAS associated with antinociception and antinociceptive
1) Confidence 0.34 Published 2001 Journal Arzneimittelforschung Section Abstract Doc Link 11715636 Disease Relevance 0.31 Pain Relevance 0.90
Methylene blue (CAS 61-73-4, MB), a guanylyl cyclase and/or NO synthase inhibitor, was antinociceptive and nociceptive at 5 and 40 mg/kg doses, respectively, 5 mg/kg dose of MB significantly increased the antinociceptive effect of pyridoxine, but did not change it at 40 mg/kg dose.
Neg (NO) Negative_regulation (inhibitor) of CAS associated with nociception and antinociceptive
2) Confidence 0.34 Published 2001 Journal Arzneimittelforschung Section Abstract Doc Link 11715636 Disease Relevance 0.33 Pain Relevance 0.94

General Comments

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