INT99419

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Context Info
Confidence 0.48
First Reported 2001
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.89
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Drd3) plasma membrane (Drd3) signal transducer activity (Drd3)
Anatomy Link Frequency
striatum 2
nucleus accumbens 1
hippocampus 1
Drd3 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 31 100.00 Very High Very High Very High
Dynorphin 1 99.48 Very High Very High Very High
Morphine 2 99.20 Very High Very High Very High
Nucleus accumbens 6 98.24 Very High Very High Very High
Hippocampus 8 97.28 Very High Very High Very High
Neuropeptide 7 96.96 Very High Very High Very High
dopamine receptor 12 96.60 Very High Very High Very High
cocaine 1 93.68 High High
Enkephalin 5 92.48 High High
Substantia nigra 6 90.88 High High
Disease Link Frequency Relevance Heat
Sprains And Strains 3 97.32 Very High Very High Very High
Watson Syndrome 28 95.32 Very High Very High Very High
Dyskinesias 5 95.12 Very High Very High Very High
Toxicity 1 91.80 High High
Targeted Disruption 7 75.00 Quite High
Dystonia 10 73.76 Quite High
Disease 3 60.92 Quite High
Cognitive Disorder 18 50.00 Quite Low
Alzheimer's Dementia 3 42.40 Quite Low
Shock 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DRD3, a member of the G alpha inhibitory G protein coupled receptor family, was also dysregulated in the mutant mice, showing a 3 fold increase in expression in the hippocampus.
Regulation (dysregulated) of DRD3 in hippocampus associated with hippocampus
1) Confidence 0.48 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.39 Pain Relevance 0.20
Dopamine D3 receptor ligands modulate the acquisition of morphine-conditioned place preference.
Regulation (modulate) of D3 receptor associated with dopamine and morphine
2) Confidence 0.37 Published 2004 Journal Psychopharmacology (Berl.) Section Title Doc Link 15095031 Disease Relevance 0 Pain Relevance 0.33
Functional changes in dopamine D3 receptors by prenatal and neonatal exposure to an endocrine disruptor bisphenol-A in mice.
Regulation (changes) of dopamine D3 associated with dopamine
3) Confidence 0.27 Published 2004 Journal Addict Biol Section Title Doc Link 15203435 Disease Relevance 0.09 Pain Relevance 0.37
There was no difference in the modulation of D3 receptor density and dynorphin (DYN) mRNA expression between the two mouse strains.
Regulation (modulation) of D3 receptor associated with dynorphin and sprains and strains
4) Confidence 0.22 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16930409 Disease Relevance 0.42 Pain Relevance 0.42
Total and subregional analysis of the striatum and nucleus accumbens showed that D-2 receptor ([3H]spiperone) binding density was increased while D-1 receptor ([3H]SCH 23390) and D-3 receptor ([3H]7-OH-DPAT) binding density was not altered.
Regulation (altered) of D-3 receptor in striatum associated with nucleus accumbens
5) Confidence 0.07 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530890 Disease Relevance 0.34 Pain Relevance 0.60
Chronic high dose L-dopa treatment does not alter the levels of dopamine D-1, D-2 or D-3 receptor in the striatum of normal monkeys: an autoradiographic study.
Neg (not) Regulation (alter) of D-3 receptor in striatum associated with dopamine
6) Confidence 0.02 Published 2001 Journal J Neural Transm Section Title Doc Link 11716146 Disease Relevance 0.32 Pain Relevance 0.28
Total and subregional analysis of the striatum and nucleus accumbens showed that D-2 receptor ([3H]spiperone) binding density was increased while D-1 receptor ([3H]SCH 23390) and D-3 receptor ([3H]7-OH-DPAT) binding density was not altered.
Regulation (altered) of D-3 receptor in nucleus accumbens associated with nucleus accumbens
7) Confidence 0.02 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530890 Disease Relevance 0.34 Pain Relevance 0.60

General Comments

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