INT99426

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Context Info
Confidence 0.59
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 13.70
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Atp2a2)
Anatomy Link Frequency
heart 6
cardiomyocytes 2
CPA 2
lumen 2
reticulum 2
Atp2a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Action potential 56 99.90 Very High Very High Very High
tetrodotoxin 5 99.78 Very High Very High Very High
action potential duration 36 99.76 Very High Very High Very High
qutenza 35 95.76 Very High Very High Very High
ischemia 95 95.36 Very High Very High Very High
fibrosis 44 92.48 High High
unmyelinated 1 89.12 High High
Calcium channel 17 88.84 High High
c fibre 1 86.16 High High
cytokine 12 81.84 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 688 99.88 Very High Very High Very High
Diabetes Mellitus 1012 99.84 Very High Very High Very High
Myocardial Infarction 220 99.82 Very High Very High Very High
Diabetic Cardiomyopathies 393 99.76 Very High Very High Very High
Coronary Heart Disease 63 99.48 Very High Very High Very High
Cardiomyopathy 51 99.44 Very High Very High Very High
Injury 47 98.80 Very High Very High Very High
Stress 129 98.40 Very High Very High Very High
Body Weight 17 97.76 Very High Very High Very High
Coronary Artery Disease 83 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Denervation or TTX treatment prevented the expression of the SERCA2 isoform.
Negative_regulation (prevented) of Gene_expression (expression) of SERCA2 isoform associated with tetrodotoxin
1) Confidence 0.59 Published 2002 Journal Exp. Physiol. Section Abstract Doc Link 12481932 Disease Relevance 0 Pain Relevance 0.25
New results are presented showing suboptimal Ca(2+) concentration in the ER lumen in association with reduced SERCA2 expression in sensory neurones from type 1 diabetic rats.
Negative_regulation (reduced) of Gene_expression (expression) of SERCA2 in lumen associated with diabetes mellitus
2) Confidence 0.52 Published 2008 Journal Cell Calcium Section Abstract Doc Link 18191198 Disease Relevance 1.25 Pain Relevance 0.06
Furthermore, SERCA overexpression decreases or prevents cardiac hypertrophy [27], [28], [29].
Negative_regulation (decreases) of Gene_expression (overexpression) of SERCA associated with coronary heart disease
3) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827566 Disease Relevance 0.29 Pain Relevance 0.13
The latter explanation seems likely because we found decreased levels of SERCA2a expression in the diabetic rat.
Negative_regulation (decreased) of Gene_expression (expression) of SERCA2a associated with diabetes mellitus
4) Confidence 0.20 Published 2008 Journal Diabetes Section Body Doc Link PMC2494698 Disease Relevance 0.58 Pain Relevance 0.04
The slower action potential and reduced SERCA2a expression can explain the slower Ca2+ transient kinetics in diabetic rats but not the contractile deficit.
Negative_regulation (reduced) of Gene_expression (expression) of SERCA2a associated with action potential and diabetes mellitus
5) Confidence 0.20 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2494698 Disease Relevance 0.83 Pain Relevance 0.09
The reduction in the level of expression of SERCA2a (?
Negative_regulation (reduction) of Gene_expression (expression) of SERCA2a
6) Confidence 0.20 Published 2008 Journal Diabetes Section Body Doc Link PMC2494698 Disease Relevance 0.39 Pain Relevance 0.05
Decreased SERCA2a expression should alter the balance of Ca2+ homeostasis in favor of increased Ca2+ extrusion via NCX and might be expected to reduce SR Ca2+ content.
Negative_regulation (Decreased) of Gene_expression (expression) of SERCA2a
7) Confidence 0.20 Published 2008 Journal Diabetes Section Body Doc Link PMC2494698 Disease Relevance 0.57 Pain Relevance 0.04
The data demonstrate that in DCM, where the expression of SERCA2 is reduced, resveratrol enhances the expression of the SERCA2 and improves cardiac function.169
Negative_regulation (reduced) of Gene_expression (expression) of SERCA2 associated with diabetic cardiomyopathies
8) Confidence 0.16 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 1.16 Pain Relevance 0.19
As previously discussed,47 a significant role in the myocardial dysfunction of DCM is supported by the reduction of the sarcoplasmic calcium ATPase myocardial expression (SERCA2).
Negative_regulation (reduction) of Gene_expression (expression) of SERCA2 associated with cardiomyopathy and diabetic cardiomyopathies
9) Confidence 0.16 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 1.33 Pain Relevance 0.24
Resveratrol treatment to these mice had a tremendous beneficial effect both in terms of improving SERCA2 expression and cardiac function.
Negative_regulation (improving) of Gene_expression (expression) of SERCA2
10) Confidence 0.16 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 1.13 Pain Relevance 0.20
Although we found almost no effects on peak Ca2+ in a variety of conditions, the finding that there was a reduced rate of SR Ca2+ uptake and SERCA2a expression was surprising, since these changes might be expected to decrease SR Ca2+ content (and therefore the amplitude of the Ca2+ transient).
Negative_regulation (reduced) of Gene_expression (expression) of SERCA2a
11) Confidence 0.14 Published 2008 Journal Diabetes Section Body Doc Link PMC2494698 Disease Relevance 0.21 Pain Relevance 0.09
Anoxia also reduced both sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) activity and Ca2+ extrusion [probably via plasma membrane Ca2+-ATPase (PMCA)].
Negative_regulation (reduced) of Gene_expression (extrusion) of SERCA in reticulum associated with hypoxia
12) Confidence 0.14 Published 2008 Journal Journal of Neurophysiology Section Abstract Doc Link PMC2493471 Disease Relevance 0.78 Pain Relevance 0.10
Figure 4 shows Western blots of SERCA2a and NCX protein expression.
Negative_regulation (blots) of Gene_expression (expression) of SERCA2a
13) Confidence 0.14 Published 2008 Journal Diabetes Section Body Doc Link PMC2494698 Disease Relevance 0.74 Pain Relevance 0
Anoxia (3 min) reduced this SERCA-mediated Ca2+ clearance to 6.2 nM/s or ?
Negative_regulation (reduced) of Gene_expression (clearance) of SERCA-mediated associated with hypoxia
14) Confidence 0.13 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.61 Pain Relevance 0
Anoxia (3 min) reduced this SERCA-mediated Ca2+ clearance to 6.2 nM/s or ?
Negative_regulation (this) of Gene_expression (clearance) of SERCA-mediated associated with hypoxia
15) Confidence 0.13 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.60 Pain Relevance 0
In support of this hypothesis, we noted that when SERCA is inhibited with CPA (10 ?
Negative_regulation (inhibited) of Gene_expression (is) of SERCA in CPA
16) Confidence 0.13 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.31 Pain Relevance 0
In many heart failure models, decreased SR Ca2+ load [33,34] due to reduced expression of SERCA protein [11,33] or impaired SERCA regulation by phospholamban [35,36] are responsible, at least in part, for the E-C uncoupling.
Negative_regulation (reduced) of Gene_expression (expression) of SERCA in heart associated with myocardial infarction
17) Confidence 0.08 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.61 Pain Relevance 0.03
In many heart failure models, decreased SR Ca2+ load [33,34] due to reduced expression of SERCA protein [11,33] or impaired SERCA regulation by phospholamban [35,36] are responsible, at least in part, for the E-C uncoupling.
Negative_regulation (decreased) of Gene_expression (expression) of SERCA in heart associated with myocardial infarction
18) Confidence 0.08 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.62 Pain Relevance 0.06
Constriction of the ascending aorta of rats resulted in an increase in the heart weight to body weight ratio, increased myocyte diameter, re-expression of the fetal genes ANF, MHCbeta and skeletal alpha-actin, and decreased expression of the adult genes GLUT4 and SERCA2a.
Negative_regulation (decreased) of Gene_expression (expression) of SERCA2a in body associated with body weight
19) Confidence 0.03 Published 2001 Journal Mol. Cell. Biochem. Section Abstract Doc Link 11716363 Disease Relevance 0.41 Pain Relevance 0.40
In conclusion, hypoxia-reoxygenation stress increases intracellular Ca2+ content via enhanced NCX-mediated Ca2+ influx and decreased SERCA2a expression resulting in myocardial cell injury through intracellular Ca2+ overload in neonatal cardiomyocytes.
Negative_regulation (decreased) of Gene_expression (expression) of SERCA2a in cardiomyocytes associated with stress, hypoxia and injury
20) Confidence 0.01 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.88 Pain Relevance 0

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