INT99427

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Context Info
Confidence 0.64
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 4.13
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Atp2a2)
Anatomy Link Frequency
nerve 2
hearts 2
body 2
Atp2a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcium channel 14 97.68 Very High Very High Very High
fibrosis 52 96.56 Very High Very High Very High
qutenza 3 95.76 Very High Very High Very High
tetrodotoxin 3 92.36 High High
unmyelinated 1 89.12 High High
c fibre 1 86.16 High High
Neuropeptide 2 81.64 Quite High
Kinase C 4 77.44 Quite High
Calcitonin gene-related peptide 1 75.00 Quite High
ischemia 20 70.32 Quite High
Disease Link Frequency Relevance Heat
Body Weight 5 100.00 Very High Very High Very High
Diabetic Cardiomyopathies 210 99.22 Very High Very High Very High
Coronary Heart Disease 54 99.08 Very High Very High Very High
Hypoxia 52 98.86 Very High Very High Very High
Cardiovascular Disorder Under Development 32 97.20 Very High Very High Very High
Hypertrophy 64 95.64 Very High Very High Very High
Diabetes Mellitus 362 88.24 High High
Myocardial Infarction 116 81.20 Quite High
Diabetes Complications 4 79.72 Quite High
Cardiomyopathy 34 73.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The overexpression of SERCA2a in diseased hearts has been shown to result in the recovery of contractility [23], [24], [25] and in improved survival, corresponding with an improvement in energy consumption [26].
Positive_regulation (overexpression) of Gene_expression (overexpression) of SERCA2a in hearts
1) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827566 Disease Relevance 0.33 Pain Relevance 0.15
Furthermore, SERCA overexpression decreases or prevents cardiac hypertrophy [27], [28], [29].
Positive_regulation (overexpression) of Gene_expression (overexpression) of SERCA associated with coronary heart disease
2) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827566 Disease Relevance 0.28 Pain Relevance 0.13
These data indicate that nerve impulses play a determinant role in the expression of the SERCA2 isoform.
Spec (determinant) Positive_regulation (role) of Gene_expression (expression) of SERCA2 isoform in nerve
3) Confidence 0.47 Published 2002 Journal Exp. Physiol. Section Abstract Doc Link 12481932 Disease Relevance 0 Pain Relevance 0.23
Treatment with breviscapine reversed the cardiac dysfunction and structure changes in rats with DCM, decreased the expression of PKC, and increased the expression of calcium handling regulators, ie, protein phosphatase inhibitor-1, phospholamban, and SERCA2.
Positive_regulation (increased) of Gene_expression (expression) of SERCA2 associated with diabetic cardiomyopathies
4) Confidence 0.18 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 1.26 Pain Relevance 0.04
The data demonstrate that in DCM, where the expression of SERCA2 is reduced, resveratrol enhances the expression of the SERCA2 and improves cardiac function.169
Positive_regulation (enhances) of Gene_expression (expression) of SERCA2 associated with diabetic cardiomyopathies
5) Confidence 0.17 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 1.16 Pain Relevance 0.19
Constriction of the ascending aorta of rats resulted in an increase in the heart weight to body weight ratio, increased myocyte diameter, re-expression of the fetal genes ANF, MHCbeta and skeletal alpha-actin, and decreased expression of the adult genes GLUT4 and SERCA2a.
Positive_regulation (increase) of Gene_expression (expression) of SERCA2a in body associated with body weight
6) Confidence 0.04 Published 2001 Journal Mol. Cell. Biochem. Section Abstract Doc Link 11716363 Disease Relevance 0.43 Pain Relevance 0.40
Treatment of hypoxia-reoxygenated cells with 50 ┬ÁM thiopental resulted in up-regulation of mRNA transcription levels of SERCA2a and PMCA1 (p < 0.05), and decreased NCX gene expression (p < 0.01).
Positive_regulation (regulation) of Gene_expression (levels) of SERCA2a associated with hypoxia
7) Confidence 0.02 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.66 Pain Relevance 0

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