INT99438

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 4.28
Pain Relevance 5.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Atf6b) nucleus (Atf6b) intracellular (Atf6b)
DNA binding (Atf6b)
Anatomy Link Frequency
intermediary 1
neurons 1
Atf6b (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 31 100.00 Very High Very High Very High
Kinase C 19 100.00 Very High Very High Very High
antidepressant 175 99.98 Very High Very High Very High
Spinal cord 6 99.84 Very High Very High Very High
withdrawal 7 99.70 Very High Very High Very High
Morphine 13 99.22 Very High Very High Very High
Cholecystokinin 96 99.04 Very High Very High Very High
opioid receptor 1 98.84 Very High Very High Very High
Hippocampus 40 97.60 Very High Very High Very High
addiction 6 97.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 56 99.14 Very High Very High Very High
Depression 177 96.20 Very High Very High Very High
Aging 3 95.80 Very High Very High Very High
Stress 45 95.44 Very High Very High Very High
Psychosis 6 94.72 High High
INFLAMMATION 13 93.84 High High
Repression 1 93.16 High High
Anxiety Disorder 28 91.44 High High
Ganglion Cysts 7 90.36 High High
Drug Dependence 6 79.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antidepressants up-regulate the cAMP response element binding protein (CREB) and the brain-derived neurotrophic factor (BDNF) in hippocampus and these effects contribute to the protection of hippocampal neurons from stressful stimuli such as high glucocorticoid levels.
Positive_regulation (up-regulate) of cAMP response element binding protein in neurons associated with antidepressant and hippocampus
1) Confidence 0.49 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 15555640 Disease Relevance 0.18 Pain Relevance 0.46
This increased excitability was mediated by direct activation of opioid receptors and up-regulation of the cAMP pathway and accompanied by increased cAMP response-element binding protein (CREB) activity.
Positive_regulation (increased) of cAMP response-element binding protein associated with opioid receptor
2) Confidence 0.46 Published 2010 Journal Proc. Natl. Acad. Sci. U.S.A. Section Abstract Doc Link 20837544 Disease Relevance 0.07 Pain Relevance 1.19
Additionally, NAN-190 decreased and 8-OH-DPAT increased phosphorylated cAMP response element-binding protein (CREB) levels in WT mice but not in KO mice.
Positive_regulation (increased) of cAMP response element-binding protein
3) Confidence 0.46 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20164327 Disease Relevance 0.60 Pain Relevance 0.35
The underlying molecular mechanisms controlling neurogenesis are not fully understood, but may involve activation of the cAMP response-element binding protein (CREB) cascade.
Positive_regulation (activation) of cAMP response-element binding protein associated with neurodegenerative disease
4) Confidence 0.44 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC434499 Disease Relevance 0.85 Pain Relevance 0.31
Different requirements for cAMP response element binding protein in positive and negative reinforcing properties of drugs of abuse.
Positive_regulation (requirements) of cAMP response element binding protein
5) Confidence 0.43 Published 2001 Journal J. Neurosci. Section Title Doc Link 11717377 Disease Relevance 0.07 Pain Relevance 0.28
Chronic morphine exposure and withdrawal significantly increased phosphorylation of N-methyl-D-aspartate receptor subunit NR2B as well as the activated forms of extracellular signal-regulated kinase and the cAMP response element binding protein in SC.
Positive_regulation (increased) of cAMP response element binding protein associated with nmda receptor, withdrawal, spinal cord and morphine
6) Confidence 0.36 Published 2009 Journal FASEB J. Section Abstract Doc Link 18772347 Disease Relevance 0.23 Pain Relevance 1.34
The action of CCK on CART expression was shown to be mediated by activation of protein kinase C and cAMP response element binding protein (CREB) and was inhibited by orexigenic ghrelin [25].
Positive_regulation (activation) of cAMP response element binding protein associated with kinase c and cholecystokinin
7) Confidence 0.33 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0.15 Pain Relevance 0.68
Coactivators such as cAMP response element-binding protein (CBP) and p300 are thought to act as histone acetyltransferases that cause chromatin decondensation to prepare promoters for the recruitment of the RNA polymerase.
Positive_regulation (Coactivators) of cAMP response element-binding protein
8) Confidence 0.18 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912024 Disease Relevance 0.09 Pain Relevance 0
The concomitant increases of both the transcription factor cAMP response element-binding protein (CREB) and hippocampal neurogenesis in response to chronic antidepressant treatment, but not to non-antidepressant psychotic drugs, strongly suggest that CREB regulates hippocampal neurogenesis [13],[38].
Positive_regulation (increases) of cAMP response element associated with antidepressant, psychosis and neurodegenerative disease
9) Confidence 0.16 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.62 Pain Relevance 0.18
In slice preparations, it has been shown that NO–cGMP–PKG resulted in the phosphorylation of the transcription factor CREB (cAMP response element binding protein) in the cell bodies of postsynaptic neurones by a mechanism involving Ca2+ release from ryanodine-sensitive stores (Lu et al., 1999; Lu & Hawkins, 2002), implicating cyclic ADP ribose as an intermediary.
Positive_regulation (resulted) of cAMP response element binding protein in intermediary
10) Confidence 0.13 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.09 Pain Relevance 0.23
It may be suggested that [18] long-term antidepressant treatment up-regulates cAMP pathway [24], in turn activating the transcription factor cAMP response element binding protein (CREB)[25], increasing BDNF gene expression [15,26,27].
Positive_regulation (activating) of cAMP response element binding protein associated with antidepressant
11) Confidence 0.10 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2169225 Disease Relevance 1.11 Pain Relevance 0.56
CREB is a member of the leucine zipper family of transcription factors, activating or repressing multiple genes with the cAMP response element (CRE) promoter (Yamamoto et al 1988).
Positive_regulation (activating) of cAMP response element
12) Confidence 0.06 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.21 Pain Relevance 0.39

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