INT99443

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Context Info
Confidence 0.23
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 5.28
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Proc) extracellular space (Proc) extracellular region (Proc)
Anatomy Link Frequency
osteoblast 1
nucleus 1
Proc (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 75 99.36 Very High Very High Very High
Inflammation 28 68.84 Quite High
Nerve growth factor 2 67.52 Quite High
antagonist 2 52.72 Quite High
Spinal cord 2 44.92 Quite Low
superficial lamina 1 44.16 Quite Low
chemokine 5 43.44 Quite Low
fibrosis 4 30.36 Quite Low
anesthesia 3 25.00 Low Low
nociceptor 32 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 309 100.00 Very High Very High Very High
Metastasis 216 99.92 Very High Very High Very High
Ganglion Cysts 87 99.36 Very High Very High Very High
Targeted Disruption 94 99.30 Very High Very High Very High
Hypoxia 154 98.80 Very High Very High Very High
Aging 37 98.76 Very High Very High Very High
Burns 8 95.68 Very High Very High Very High
Breast Cancer 68 95.04 Very High Very High Very High
Osteoporosis 26 93.76 High High
Apoptosis 24 90.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The agent may act by causing an upregulation of the growth factors, as well as influencing other local factors.
Regulation (influencing) of factors
1) Confidence 0.23 Published 2001 Journal Burns Section Abstract Doc Link 11718984 Disease Relevance 0.45 Pain Relevance 0.07
In the nucleus, Akt isoforms have been hypothesized to phosphorylate and modulate the activity of transcription factors [56].
Regulation (modulate) of factors in nucleus
2) Confidence 0.01 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.22 Pain Relevance 0.03
Confounding factors such as husbandry, environment, and genetic background were likely responsible for the discrepancies, as several laboratories did not observe the reduced lifespans reported by Fabris and co-workers (1972; Silberberg 1972; Bartke et al. 1977; Schneider 1976; Shire 1973).
Spec (likely) Regulation (responsible) of factors
3) Confidence 0.01 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.69 Pain Relevance 0
signaling pathways regulate tumor-secreted factors such as CXCR4 which promotes tumor cell homing to the bone [50], and VEGF which stimulates tumor angiogenesis and increases both osteoclast [65], [69] and osteoblast activity [61].
Regulation (regulate) of factors in osteoblast associated with cancer and osteoporosis
4) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.35 Pain Relevance 0
promotes bone metastases by regulating factors such as CXCR4, which promotes tumor cell homing to bone [50] and VEGF, which promotes angiogenesis.
Regulation (regulating) of factors associated with cancer and metastasis
5) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.47 Pain Relevance 0.03
We then plotted the changes in gene expression in the VP16-Brn3a mouse against changes observed in Brn3a knockout TG (Figure 6E), revealing similar regulation of key developmental transcription factors (Figure 6F).
Regulation (regulation) of factors associated with targeted disruption and trigeminal ganglion
6) Confidence 0.00 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.66 Pain Relevance 0.11
There is also participation in the transcriptional regulation of growth factors such as EGF through JNK activation [61].
Regulation (regulation) of factors
7) Confidence 0.00 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.43 Pain Relevance 0

General Comments

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