INT99444

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Context Info
Confidence 0.45
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 9.18
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Proc) extracellular space (Proc) extracellular region (Proc)
Anatomy Link Frequency
eye 1
plasma 1
cartilage 1
neurons 1
vessels 1
Proc (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 96 100.00 Very High Very High Very High
cINOD 25 99.16 Very High Very High Very High
metalloproteinase 14 98.28 Very High Very High Very High
ischemia 30 96.56 Very High Very High Very High
antagonist 2 95.12 Very High Very High Very High
chemokine 6 91.12 High High
cytokine 29 90.24 High High
Pain 14 90.04 High High
Osteoarthritis 42 84.52 Quite High
Inflammatory stimuli 3 82.80 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 118 100.00 Very High Very High Very High
Coagulation Disorder 8 100.00 Very High Very High Very High
Stress 29 99.90 Very High Very High Very High
Ocular Hypertension 57 99.60 Very High Very High Very High
Middle Cerebral Artery Infarction 8 98.32 Very High Very High Very High
Stroke 80 97.68 Very High Very High Very High
Burns 8 97.56 Very High Very High Very High
Toxicity 6 97.20 Very High Very High Very High
Fibrosis 45 96.92 Very High Very High Very High
Cv Unclassified Under Development 39 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activated protein C (APC) is a serine protease with potent anti-inflammatory effects.
Positive_regulation (Activated) of protein C associated with inflammation
1) Confidence 0.45 Published 2004 Journal Blood Section Abstract Doc Link 14604971 Disease Relevance 0.94 Pain Relevance 0.37
Human activated protein C functions as a potent anticoagulant in human plasma by inhibiting the activity of coagulation cofactors Va and VIIIa.
Positive_regulation (activated) of protein C in plasma
2) Confidence 0.45 Published 2003 Journal Rinsho Shinkeigaku Section Abstract Doc Link 15152454 Disease Relevance 1.18 Pain Relevance 0
The agent may act by causing an upregulation of the growth factors, as well as influencing other local factors.
Positive_regulation (upregulation) of factors
3) Confidence 0.39 Published 2001 Journal Burns Section Abstract Doc Link 11718984 Disease Relevance 0.46 Pain Relevance 0.07
Taken together, these data and our results confirm the critical role of aggrecanases in cartilage destruction and suggest that a controlled level of MMP-mediated aggrecanolysis may be needed for cartilage homeostasis, and possibly repair, as MMPs proteolysis can facilitate cell migration, regulate tissue architecture, release and activate ECM bound growth factors and signaling molecules49.
Positive_regulation (activate) of factors in cartilage associated with metalloproteinase
4) Confidence 0.01 Published 2009 Journal Osteoarthritis Cartilage Section Body Doc Link PMC2706394 Disease Relevance 0.29 Pain Relevance 0.35
As in many aspects of cell function, the rapid activation of transcription factors in neurons is part of an early genomic response that constitutes a critical step in the molecular mechanisms required for persistent neuronal modification and the laying down of long-term memories.
Positive_regulation (activation) of factors in neurons
5) Confidence 0.01 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0 Pain Relevance 0
In order to search for therapeutic targets other than receptors themselves, we set forth to determine the transcription factors downstream of PAR activation as the next step in elucidating the network of responses at the molecular level to PAR activation.
Positive_regulation (activation) of factors
6) Confidence 0.01 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.76 Pain Relevance 0.50
Thus, the upregulation of PGE2 by PK might contribute to its healing activity primarily via increasing the levels of mucin, and other growth factors, and to a lesser extent due to inhibition to gastric secretion.
Positive_regulation (increasing) of factors
7) Confidence 0.01 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266895 Disease Relevance 0.28 Pain Relevance 0
Its healing action could be attributed to the antioxidant activity along with the ability to modulate mucin secretion, PG synthesis, and upregulation of the growth factors.
Positive_regulation (upregulation) of factors
8) Confidence 0.01 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266895 Disease Relevance 0.33 Pain Relevance 0
and 1% O2, and promoter activation of the two factors was also additively increased by combined treatment.
Positive_regulation (activation) of factors
9) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.13 Pain Relevance 0
It is highly likely that other signals and transcription factors are necessary to confer specificity on Runx3 activation by Brn3a.
Positive_regulation (necessary) of factors
10) Confidence 0.01 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.07 Pain Relevance 0
Each model has advantages and disadvantages, related to factors such as the ease of inducing elevated IOP, the magnitude, duration and variability of elevated IOP, and secondary effects on the eye.
Positive_regulation (inducing) of factors in eye associated with ocular hypertension
11) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 1.05 Pain Relevance 0
In the conduit vessels, which include larger arteries such as the aorta and the carotid/coronary/ brachial/femoral arteries, a healthy endothelium provides a smooth, quiescent surface that limits the activation of clotting and proinflammatory factors.
Positive_regulation (activation) of factors in endothelium associated with coagulation disorder
12) Confidence 0.01 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.58 Pain Relevance 0.15
Although smaller epifluorescence apertures and laser targeting to individual arteries were associated with smaller strokes it was difficult to predict the size of RB strokes due to the interconnected nature of the rodent surface vessels [16] and potential for the clots themselves or clot inducing factors to diffuse.
Positive_regulation (inducing) of factors in vessels associated with stroke
13) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1854912 Disease Relevance 0.65 Pain Relevance 0.09
For example, proteins contributing to angiogenesis (VEGFR1), extracellular matrix remodeling (MMP-2 and MMP-3) were not upregulated in ischemic/reperfused muscles as compared to myotoxin injured muscles, whereas some factors regulating the activation and migration of leukocytes in injured tissues (MIP-1, MIP-2 and MIP-3) and inflammation (sTNF R1 and sTNF R2) were increased in ischemic/reperfused muscles (Table 1).
Positive_regulation (increased) of factors in extracellular matrix associated with inflammation
14) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2866363 Disease Relevance 0.31 Pain Relevance 0.16
The fibrotic tissue also contained nitrosylated proteins concordant with elevated numbers of chymase and FGF producing mast cells, indicative of oxidative stress and increased fibroproliferative factors driving cell survival and proliferation.
Positive_regulation (increased) of factors in mast cells associated with stress and fibrosis
15) Confidence 0.00 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 1.15 Pain Relevance 0.06

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