INT9945

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Context Info
Confidence 0.51
First Reported 1986
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 35
Total Number 35
Disease Relevance 17.85
Pain Relevance 11.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Csf2) extracellular region (Csf2)
Anatomy Link Frequency
CSF 9
outflow 5
spinal 2
blood 2
MGRF 1
Csf2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 18 99.98 Very High Very High Very High
nMDA receptor 16 99.88 Very High Very High Very High
acular 12 99.76 Very High Very High Very High
Multiple sclerosis 57 99.64 Very High Very High Very High
Paracetamol 166 99.56 Very High Very High Very High
intrathecal 8 99.56 Very High Very High Very High
cva 37 99.52 Very High Very High Very High
Central nervous system 39 98.86 Very High Very High Very High
tolerance 5 98.80 Very High Very High Very High
Morphine 15 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 14 99.64 Very High Very High Very High
Cv General 3 Under Development 27 99.52 Very High Very High Very High
Bacterial Meningitis 8 99.40 Very High Very High Very High
Disease 296 99.26 Very High Very High Very High
Schizophrenia 22 99.24 Very High Very High Very High
Calcification 23 99.16 Very High Very High Very High
Disorder Of Lipid Metabolism 10 98.72 Very High Very High Very High
Hydrocephalus 316 98.66 Very High Very High Very High
Leukocytosis 3 98.56 Very High Very High Very High
Injury 22 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decrease in [Na]CSF occurred sooner in dehydrated than in euhydrated rats in response to the decrease in [Na]p (P < 0.01).
Negative_regulation (decrease) of CSF
1) Confidence 0.51 Published 1992 Journal J. Appl. Physiol. Section Abstract Doc Link 1447087 Disease Relevance 0.07 Pain Relevance 0.08
Damage to the bulbospinal serotonergic fibers also occurs in patients with MS (as reflected by reduced lumbar CSF 5-HIAA levels) and may contribute to several manifestations of the disease including autonomic dysregulation, sensory symptoms (i.e., paresthesias, pain) and motor symptoms (weakness, spasticity, clonus).
Negative_regulation (reduced) of CSF in autonomic associated with pain, dysesthesia, multiple sclerosis, spasticity and disease
2) Confidence 0.51 Published 1999 Journal Int. J. Neurosci. Section Abstract Doc Link 10681122 Disease Relevance 1.65 Pain Relevance 0.39
CSF 5-HIAA concentrations were also decreased to 77% and 66%, respectively.
Negative_regulation (decreased) of CSF 5-HIAA in CSF
3) Confidence 0.43 Published 1993 Journal Life Sci. Section Abstract Doc Link 8102468 Disease Relevance 0 Pain Relevance 0.61
Intrathecal ketorolac (4 microg) reduced CSF PGE2 after surgery without affecting tissue PGE2 levels, whereas intrathecal L-745,337 (80 microg) did not reduce CSF PGE2.
Neg (not) Negative_regulation (reduce) of CSF PGE2 in CSF associated with acular and intrathecal
4) Confidence 0.43 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16861414 Disease Relevance 0.45 Pain Relevance 0.93
RESULTS: We found that GM-CSF increases efferent electric activity in the splenic nerve and decreases that of MGRF as is evident by the frequency of electric discharges.
Negative_regulation (decreases) of GM-CSF in MGRF
5) Confidence 0.43 Published 2004 Journal Neuroimmunomodulation Section Body Doc Link 14557677 Disease Relevance 0 Pain Relevance 0
Decreased CSF 5-HT and 5-HIAA concentrations after i.v. administration of clonidine (30 micrograms/kg) were abolished by noradrenergic denervation after pretreatment with 6-hydroxydopamine (200 micrograms/rat, i.c.v.).
Negative_regulation (Decreased) of CSF in CSF associated with clonidine
6) Confidence 0.38 Published 1993 Journal Life Sci. Section Abstract Doc Link 8102468 Disease Relevance 0 Pain Relevance 0.73
Intrathecal ketorolac (4 microg) reduced CSF PGE2 after surgery without affecting tissue PGE2 levels, whereas intrathecal L-745,337 (80 microg) did not reduce CSF PGE2.
Negative_regulation (reduced) of CSF PGE2 in CSF associated with acular and intrathecal
7) Confidence 0.38 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16861414 Disease Relevance 0.45 Pain Relevance 0.96
With surgery under isoflurane or spinal bupivacaine, presurgical oral administration of ketorolac or rofecoxib 3 mg/kg reduced postsurgical CSF PGE2 levels and tissue PGE2 levels.
Negative_regulation (reduced) of CSF PGE2 in spinal associated with acular and isoflurane
8) Confidence 0.38 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16861414 Disease Relevance 0.45 Pain Relevance 0.98
The alpha 2-agonists reduced the concentration of MHPG in CSF, indicating a decreased release, metabolism and turnover of noradrenaline in the CNS.
Negative_regulation (reduced) of CSF in CNS associated with noradrenaline, agonist and central nervous system
9) Confidence 0.37 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2872072 Disease Relevance 0 Pain Relevance 0.44
The alpha 2-agonists caused a dose-dependent, statistically significant decrease in the concentration of MHPG in CSF compared to the concentration in animals treated with saline or diazepam.
Negative_regulation (decrease) of CSF in CSF associated with agonist
10) Confidence 0.37 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2872072 Disease Relevance 0 Pain Relevance 0.42
Elevated CSF concentrations of fibroblast growth factor (FGF-2) are associated with hydrocephalus and when FGF-2 is introduced into the ventricular system of rats, CSF formation rate declines and CSF outflow resistance increases [3].
Negative_regulation (declines) of CSF in outflow associated with hydrocephalus
11) Confidence 0.35 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2831828 Disease Relevance 0.64 Pain Relevance 0.15
Taken together, the data suggest that the kaolin-induced reduction in lymphatic CSF uptake plays a major role in the increased outflow resistance.
Negative_regulation (reduction) of CSF in outflow
12) Confidence 0.35 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2831828 Disease Relevance 0.26 Pain Relevance 0.05
While not measured in our study, CSF removal from the spinal subarachnoid compartment in the kaolin rat model may have been compromised as well.
Negative_regulation (removal) of CSF in spinal
13) Confidence 0.35 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2831828 Disease Relevance 0.08 Pain Relevance 0.04
The latter is the result of dilution within the third ventricle by inflowing unlabeled CSF from the contralateral lateral ventricle and by production of fresh CSF by the third ventricle choroid plexus.
Negative_regulation (inflowing) of CSF in third ventricle choroid plexus
14) Confidence 0.35 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1190198 Disease Relevance 0.13 Pain Relevance 0.12
Collagen deposits were observed in the arachnoid membrane and likely impeded CSF flow in this model.
Negative_regulation (impeded) of CSF
15) Confidence 0.35 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2831828 Disease Relevance 0.66 Pain Relevance 0.16
Third, in sheep in which a similar proportion of CSF absorption occurs through this pathway, sealing the cribriform plate on the extracranial surface leads to reduction in CSF absorption [13,14], elevation of intracranial pressure [21] and a significant increase in CSF outflow resistance [22].
Negative_regulation (increase) of CSF in outflow associated with cva
16) Confidence 0.35 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2831828 Disease Relevance 0.10 Pain Relevance 0.05
In the study reported here, we observed a decline in global CSF absorption in a communicating form of hydrocephalus and this impediment correlated significantly with increasing ventricular size.
Negative_regulation (decline) of CSF associated with hydrocephalus
17) Confidence 0.35 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2831828 Disease Relevance 0.56 Pain Relevance 0
Third, in sheep in which a similar proportion of CSF absorption occurs through this pathway, sealing the cribriform plate on the extracranial surface leads to reduction in CSF absorption [13,14], elevation of intracranial pressure [21] and a significant increase in CSF outflow resistance [22].
Negative_regulation (reduction) of CSF in outflow associated with cva
18) Confidence 0.35 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2831828 Disease Relevance 0.10 Pain Relevance 0.05
The morphine concentrations in the blood and intrathecal cerebrospinal fluid (CSF) were gradually decreased by the repeated treatment with morphine.
Negative_regulation (decreased) of CSF in cerebrospinal fluid associated with intrathecal and morphine
19) Confidence 0.30 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 19043223 Disease Relevance 0 Pain Relevance 1.82
Such transfer was not, however, achieved on the dorsal surface of the brain, which may be due to the very low delivery of CSF-entrained substances over the cortex as observed in other studies [13,14] as well as the present one.


Negative_regulation (delivery) of CSF in brain
20) Confidence 0.30 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1190198 Disease Relevance 0 Pain Relevance 0

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