INT99454

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 1.76
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NAT2) small molecule metabolic process (NAT2) transferase activity, transferring acyl groups (NAT2)
cytoplasm (NAT2)
Anatomy Link Frequency
T24 2
liver 1
NAT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 95.24 Very High Very High Very High
Potency 18 95.16 Very High Very High Very High
Chronic pancreatitis 1 77.04 Quite High
Paracetamol 15 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bladder Cancer 29 97.80 Very High Very High Very High
Cancer 32 97.08 Very High Very High Very High
INFLAMMATION 2 95.04 Very High Very High Very High
Nicotine Addiction 37 93.08 High High
Pancreatic Cancer 7 80.64 Quite High
Pancreatitis 1 77.04 Quite High
Toxicity 9 73.20 Quite High
Stress 4 59.56 Quite High
Multiple Chemical Sensitivity 20 5.00 Very Low Very Low Very Low
Disease 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Table 3 shows the distribution of NAT2, GSTM1, GSTT1, and GSTP1 genotypes by self-reported chemical-related sensitivity score (?
Gene_expression (distribution) of NAT2
1) Confidence 0.67 Published 2007 Journal Environ Health Section Body Doc Link PMC1802749 Disease Relevance 0.18 Pain Relevance 0
In two cell lines both expressing CYP1A2 and NAT2, but one deficient in NER, 2,6-DMA and 3,5-DMA were cytotoxic and mutagenic at dose levels between 100 ?
Gene_expression (expressing) of NAT2
2) Confidence 0.63 Published 2010 Journal Carcinogenesis Section Body Doc Link PMC2802674 Disease Relevance 0.07 Pain Relevance 0.09
Using the same three alkylanilines listed in Table I, we assessed DNA binding of radioisotope catalyzed by human liver S9 in the absence and presence of cofactors that promote N-acetyltransferase (NAT), sulfotransferase and glucuronyl transferase activities.
Gene_expression (promote) of N-acetyltransferase in liver
3) Confidence 0.55 Published 2010 Journal Carcinogenesis Section Body Doc Link PMC2802674 Disease Relevance 0 Pain Relevance 0
In two cell lines both deficient in NER and one expressing CYP1A2 and NAT2, 2,6-DMA and 3,5-DMA were cytotoxic at dose levels of 100 ?
Gene_expression (one) of NAT2
4) Confidence 0.55 Published 2010 Journal Carcinogenesis Section Body Doc Link PMC2802674 Disease Relevance 0.06 Pain Relevance 0.08
Sulindac inhibited gene expression and activity of arylamine N-acetyltransferase and DNA-2-aminofluorene adduct formation in T24 human bladder tumor cells.
Gene_expression (expression) of arylamine N-acetyltransferase in T24 associated with bladder cancer
5) Confidence 0.49 Published 2001 Journal Urol. Res. Section Title Doc Link 11828994 Disease Relevance 0.28 Pain Relevance 0.10
Polymorphisms of the CYP1A1, CYP2E1, NAT1, NAT2, GSTM1, MnSOD, and hOGG1 genes were determined in these patients.
Spec (determined) Gene_expression (determined) of NAT2
6) Confidence 0.46 Published 2002 Journal Mutat. Res. Section Abstract Doc Link 11719088 Disease Relevance 0.91 Pain Relevance 0.08
The aim of the present study was to determine whether sulindac affects arylamine N-acetyltransferase (NAT) activity and gene expression and DNA-2-aminofluorene adduct formation in the T24 human bladder tumor cell line.
Gene_expression (expression) of arylamine N-acetyltransferase in T24 associated with bladder cancer
7) Confidence 0.42 Published 2001 Journal Urol. Res. Section Abstract Doc Link 11828994 Disease Relevance 0.27 Pain Relevance 0.09

General Comments

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