INT9946

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Context Info
Confidence 0.52
First Reported 1981
Last Reported 1998
Negated 2
Speculated 0
Reported most in Abstract
Documents 27
Total Number 27
Disease Relevance 2.47
Pain Relevance 11.08

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signal transduction (LHB) small molecule metabolic process (LHB) extracellular region (LHB)
cellular nitrogen compound metabolic process (LHB) cell-cell signaling (LHB)
Anatomy Link Frequency
follicle 8
blood 4
plasma 2
brain 2
pituitary 2
LHB (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 125 100.00 Very High Very High Very High
Endogenous opioid 23 100.00 Very High Very High Very High
Morphine 23 100.00 Very High Very High Very High
antagonist 13 100.00 Very High Very High Very High
ketamine 11 100.00 Very High Very High Very High
opiate 11 100.00 Very High Very High Very High
Dopamine 11 100.00 Very High Very High Very High
anesthesia 5 100.00 Very High Very High Very High
opioid receptor 5 100.00 Very High Very High Very High
Opioid 20 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Reprotox - General 1 14 99.32 Very High Very High Very High
Cluster Headache 10 98.56 Very High Very High Very High
Endometriosis (extended) 1 98.40 Very High Very High Very High
Disease 6 98.32 Very High Very High Very High
Hypogonadotropic Hypogonadism 1 93.80 High High
Schizophrenia 1 88.64 High High
Stress 2 75.00 Quite High
Hallucination 1 71.84 Quite High
Parkinson's Disease 1 63.56 Quite High
Heart Rate Under Development 1 52.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study evaluated the activity of central opiate receptors modulating luteinizing hormone (LH) secretion before and during treatment with human menopausal gonadotropin (n = 8) or purified human urinary follicle-stimulating hormone (n = 6) in 14 patients with hypogonadotropic hypogonadism (n = 6) or secondary amenorrhea (n = 8).
Regulation (modulating) of Localization (secretion) of luteinizing hormone in follicle associated with endometriosis (extended), hypogonadotropic hypogonadism, opiate and reprotox - general 1
1) Confidence 0.52 Published 1987 Journal Fertil. Steril. Section Abstract Doc Link 3032691 Disease Relevance 0.34 Pain Relevance 0.28
Dopamine is not involved in the opioid control of luteinizing hormone secretion in man.
Regulation (control) of Localization (secretion) of luteinizing hormone associated with dopamine and opioid
2) Confidence 0.40 Published 1985 Journal Fertil. Steril. Section Title Doc Link 4054321 Disease Relevance 0 Pain Relevance 0.58
The aim of this study was to examine the role of the central dopaminergic system in the mechanisms by which opioid peptides exert their influence on luteinizing hormone (LH) secretion in man.
Regulation (influence) of Localization (secretion) of luteinizing hormone associated with opioid
3) Confidence 0.40 Published 1985 Journal Fertil. Steril. Section Abstract Doc Link 4054321 Disease Relevance 0 Pain Relevance 0.49
In addition, the effects of ketamine on behavior, vital signs, homovanillic acid (HVA) plasma levels and secretion of cortisol and luteinizing hormone (LH) were also determined.
Regulation (effects) of Localization (secretion) of luteinizing hormone in plasma associated with ketamine
4) Confidence 0.31 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9683005 Disease Relevance 0.21 Pain Relevance 0.61
Endogenous opiates modulate pulsatile luteinizing hormone release in humans.
Regulation (modulate) of Localization (release) of luteinizing hormone associated with narcan and opiate
5) Confidence 0.30 Published 1981 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 6780598 Disease Relevance 0 Pain Relevance 0.50
Evidence for serotoninergic system involvement in opioid control of luteinizing hormone secretion in man.
Regulation (control) of Localization (secretion) of luteinizing hormone associated with narcan and opioid
6) Confidence 0.24 Published 1986 Journal Clin. Endocrinol. (Oxf) Section Title Doc Link 3621624 Disease Relevance 0 Pain Relevance 0.79
The circadian changes in testosterone (T) and cortisol secretion and morning luteinizing hormone (LH) levels were evaluated in nine episodic cluster headache (CH) patients in active phase and in seven healthy volunteers, with collection of blood samples every 2 h for 24 h.
Regulation (changes) of Localization (secretion) of luteinizing hormone in blood associated with cluster headache
7) Confidence 0.18 Published 1986 Journal Cephalalgia Section Abstract Doc Link 3698090 Disease Relevance 0.61 Pain Relevance 0.54
The influence of ovariectomy and steroid replacement on naloxone-induced changes in pulsatile secretion of luteinizing hormone (LH) in the female rabbit was examined.
Regulation (influence) of Localization (secretion) of luteinizing hormone associated with narcan
8) Confidence 0.10 Published 1988 Journal Biol. Reprod. Section Abstract Doc Link 3196795 Disease Relevance 0 Pain Relevance 0.12
Opioidergic control of luteinizing hormone release in the female rabbit: influence of ovariectomy and steroid replacement on pulsatile secretion.
Regulation (control) of Localization (release) of luteinizing hormone associated with narcan
9) Confidence 0.10 Published 1988 Journal Biol. Reprod. Section Title Doc Link 3196795 Disease Relevance 0 Pain Relevance 0.23
Naltrexone administration modulates the neuroendocrine control of luteinizing hormone secretion in hypothalamic amenorrhoea.
Regulation (modulates) of Localization (secretion) of luteinizing hormone associated with reprotox - general 1
10) Confidence 0.08 Published 1995 Journal Hum. Reprod. Section Title Doc Link 8747034 Disease Relevance 0.36 Pain Relevance 0.19
Effects of pentobarbital anesthesia on tonic luteinizing hormone secretion in the ewe: evidence for active inhibition of luteinizing hormone in anestrus.
Regulation (Effects) of Localization (secretion) of luteinizing hormone associated with anesthesia
11) Confidence 0.06 Published 1984 Journal Biol. Reprod. Section Title Doc Link 6538445 Disease Relevance 0 Pain Relevance 0.35
The influence of ovariectomy and steroid replacement on naloxone-induced changes in pulsatile secretion of luteinizing hormone (LH) in the female rabbit was examined.
Regulation (changes) of Localization (secretion) of luteinizing hormone associated with narcan
12) Confidence 0.04 Published 1988 Journal Biol. Reprod. Section Abstract Doc Link 3196795 Disease Relevance 0 Pain Relevance 0.12
To determine the role of endogenous opioid peptides in regulating pulsatile luteinizing hormone (LH) release in the early follicular phase of the menstrual cycle of eumenorrheic women, we evaluated serum LH concentrations in blood collected every 10 min for 12 h in 27 women each studied during two menstrual cycles: (1) without pretreatment and (2) following oral administration of naltrexone, a mu opiate receptor blocking agent, at a dose of 1.0 mg/kg.
Regulation (regulating) of Localization (release) of luteinizing hormone in blood associated with opioid receptor 1 and endogenous opioid
13) Confidence 0.04 Published 1992 Journal J. Endocrinol. Invest. Section Abstract Doc Link 1447490 Disease Relevance 0 Pain Relevance 0.23
Absence of brain opioid peptide modulation of luteinizing hormone secretion in the prepubertal gilt.
Regulation (modulation) of Localization (secretion) of luteinizing hormone in brain associated with narcan and opioid
14) Confidence 0.04 Published 1988 Journal Biol. Reprod. Section Title Doc Link 3196794 Disease Relevance 0 Pain Relevance 0.62
Naltrexone administration modulates the neuroendocrine control of luteinizing hormone secretion in hypothalamic amenorrhoea.
Regulation (control) of Localization (secretion) of luteinizing hormone associated with reprotox - general 1
15) Confidence 0.03 Published 1995 Journal Hum. Reprod. Section Title Doc Link 8747034 Disease Relevance 0.36 Pain Relevance 0.19
The effect of intravenous injections or infusions of the opioid receptor antagonist naloxone on the secretion of luteinizing hormone (LH) was studied in 18 spayed cats anaesthetized with Althesin.
Regulation (effect) of Localization (secretion) of luteinizing hormone associated with antagonist, narcan and opioid receptor
16) Confidence 0.03 Published 1990 Journal Neurosci. Lett. Section Abstract Doc Link 2154726 Disease Relevance 0 Pain Relevance 0.25
Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion prior to and during the gonadotrophin surge were not affected by naloxone (0.33 mg/kg body wt per h) administered from the time of medroxyprogesterone acetate withdrawal until 30 h after the onset of oestrus (n = 6).
Neg (not) Regulation (affected) of Localization (secretion) of Luteinizing hormone in body associated with narcan and withdrawal
17) Confidence 0.02 Published 1991 Journal J. Reprod. Fertil. Section Abstract Doc Link 1909367 Disease Relevance 0 Pain Relevance 0.77
Altered neuroendocrine regulation of luteinizing hormone secretion in postmenopausal women with Parkinson's disease.
Regulation (regulation) of Localization (secretion) of luteinizing hormone associated with narcan and disease
18) Confidence 0.02 Published 1991 Journal Neuroendocrinology Section Title Doc Link 1678880 Disease Relevance 0.40 Pain Relevance 0.39
To evaluate whether dopaminergic treatment may modify endogenous opioid activity at the hypothalamic-pituitary level, the effects of naloxone infusion (1.6 mg/h for 4 h) on luteinizing hormone (LH) secretion were studied in 5 postmenopausal women either before or after chronic administration of the dopaminergic drug bromocriptine (BCT; 5 mg/day for 30 days).
Regulation (effects) of Localization (secretion) of luteinizing hormone in pituitary associated with narcan and endogenous opioid
19) Confidence 0.02 Published 1988 Journal Neuroendocrinology Section Abstract Doc Link 2830551 Disease Relevance 0 Pain Relevance 0.32
Three experiments were conducted to evaluate the role of endogenous opioid peptides (EOP) in modulating luteinizing hormone (LH) secretion in the prepubertal gilt.
Regulation (role) of Localization (secretion) of luteinizing hormone associated with endogenous opioid
20) Confidence 0.02 Published 1988 Journal Biol. Reprod. Section Abstract Doc Link 3196794 Disease Relevance 0 Pain Relevance 0.46

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