INT99477

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Context Info
Confidence 0.30
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 7
Disease Relevance 2.45
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Enpp3)
Anatomy Link Frequency
endothelial cells 1
jejunum 1
pericytes 1
astrocytes 1
Enpp3 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 60 97.98 Very High Very High Very High
Restless leg syndrome 6 97.36 Very High Very High Very High
Neurobehavioral 5 91.40 High High
imagery 10 89.48 High High
abdominal pain 1 83.88 Quite High
cva 30 73.36 Quite High
aspirin 10 55.20 Quite High
metalloproteinase 70 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Immobilon 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Brain Hemorrhage 45 97.98 Very High Very High Very High
Increased Venous Pressure Under Development 11 97.36 Very High Very High Very High
Middle Cerebral Artery Infarction 5 95.88 Very High Very High Very High
Injury 35 93.20 High High
Cerebral Edema 50 87.36 High High
Myocardial Infarction 1 86.24 High High
Abdominal Pain 1 83.88 Quite High
Stroke 45 74.64 Quite High
Cv General 3 Under Development 15 73.36 Quite High
Recurrence 5 52.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously, we have reported the isolation of glycycoumarin as a potent antispasmodic with an IC50 value of 2.93+/-0.94 microM for carbamylcholine (CCh)-induced contraction of mouse jejunum from an aqueous extract of Glycyrrhizae radix (licorice), and clarified that its mechanism of action involves inhibition of phosphodiesterase 3.
Negative_regulation (inhibition) of phosphodiesterase 3 in jejunum
1) Confidence 0.30 Published 2007 Journal Biol. Pharm. Bull. Section Abstract Doc Link 17202675 Disease Relevance 0.08 Pain Relevance 0.08
Cilostazol is a phosphodiesterase III inhibitor that has been shown to be effective for treatment of symptomatic intermittent claudication.
Negative_regulation (inhibitor) of phosphodiesterase III associated with restless leg syndrome
2) Confidence 0.29 Published 1999 Journal Heart Dis Section Abstract Doc Link 11720622 Disease Relevance 0.18 Pain Relevance 0.10
Cilostazol, a selective inhibitor of phosphodiesterase III, is an antiplatelet drug and a vasodilator via an increased cyclic AMP (cAMP) level and cyclic GMP level [4], [5].
Negative_regulation (inhibitor) of phosphodiesterase III
3) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997776 Disease Relevance 0.64 Pain Relevance 0.18
To further investigate the mechanism of cilostazol to beneficial effect, we also performed an in vitro study with tPA and a phosphodiesterase-III inhibitor in human brain microvascular endothelial cells, pericytes, and astrocytes.
Negative_regulation (inhibitor) of phosphodiesterase-III in pericytes
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2997776 Disease Relevance 0.39 Pain Relevance 0.13
Phosphodiesterase-III Inhibitor Prevents Hemorrhagic Transformation Induced by Focal Cerebral Ischemia in Mice Treated with tPA

The purpose of the present study was to investigate whether cilostazol, a phosphodiesterase-III inhibitor and antiplatelet drug, would prevent tPA-associated hemorrhagic transformation.

Negative_regulation (inhibitor) of phosphodiesterase-III associated with brain hemorrhage and ischemia
5) Confidence 0.01 Published 2010 Journal PLoS ONE Section Title Doc Link PMC2997776 Disease Relevance 0.39 Pain Relevance 0.14
To further investigate the mechanism of cilostazol to beneficial effect, we also performed an in vitro study with tPA and a phosphodiesterase-III inhibitor in human brain microvascular endothelial cells, pericytes, and astrocytes.
Negative_regulation (inhibitor) of phosphodiesterase-III in endothelial cells
6) Confidence 0.00 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2997776 Disease Relevance 0.39 Pain Relevance 0.13
To further investigate the mechanism of cilostazol to beneficial effect, we also performed an in vitro study with tPA and a phosphodiesterase-III inhibitor in human brain microvascular endothelial cells, pericytes, and astrocytes.
Negative_regulation (inhibitor) of phosphodiesterase-III in astrocytes
7) Confidence 0.00 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2997776 Disease Relevance 0.39 Pain Relevance 0.13

General Comments

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