INT99495

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Context Info
Confidence 0.77
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 23
Disease Relevance 5.00
Pain Relevance 9.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SRD5A1) small molecule metabolic process (SRD5A1) endoplasmic reticulum (SRD5A1)
cytoplasm (SRD5A1)
Anatomy Link Frequency
brain 4
myometrium 3
testis 3
liver 2
genitalia 1
SRD5A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Gabapentin 7 100.00 Very High Very High Very High
pregabalin 5 100.00 Very High Very High Very High
Pain 193 99.36 Very High Very High Very High
Morphine 530 99.00 Very High Very High Very High
Lasting pain 10 98.52 Very High Very High Very High
fluoxetine 3 97.40 Very High Very High Very High
IPN 10 95.72 Very High Very High Very High
Opioid 60 94.32 High High
noradrenaline 1 93.04 High High
gABA 5 92.64 High High
Disease Link Frequency Relevance Heat
Cancer 205 99.84 Very High Very High Very High
Pain 203 99.36 Very High Very High Very High
Congenital Anomalies 6 99.24 Very High Very High Very High
Breast Cancer 69 98.80 Very High Very High Very High
Inflammatory Pain 10 95.72 Very High Very High Very High
Aggression 2 90.24 High High
Anxiety Disorder 7 89.28 High High
Apoptosis 1 86.48 High High
Reprotox - General 2 11 85.00 Quite High
Pathologic Constriction 6 84.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SRD5A1 mRNA expression was significantly lower in the membranes of both laboring groups when compared with those not in labor (spontaneous: 0.10-fold [0.06 to 0.18], P = 0.007; induced: 0.09-fold [0.03 to 0.25], P = 0.013).
Gene_expression (expression) of SRD5A1 mRNA
1) Confidence 0.77 Published 2008 Journal Am J Perinatol Section Abstract Doc Link 18770491 Disease Relevance 0.08 Pain Relevance 0.08
Regardless of labor status, there was no difference in SRD5A1 mRNA expression in the myometrium.
Gene_expression (expression) of SRD5A1 mRNA in myometrium
2) Confidence 0.77 Published 2008 Journal Am J Perinatol Section Abstract Doc Link 18770491 Disease Relevance 0.07 Pain Relevance 0.07
Molecular biological and biochemical studies have now firmly established the presence of the steroidogenic enzymes cytochrome P450 cholesterol side-chain cleavage (P450SCC), aromatase, 5alpha-reductase, 3alpha-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase in human brain.
Gene_expression (presence) of 5alpha-reductase in brain
3) Confidence 0.75 Published 2001 Journal Eur. J. Endocrinol. Section Abstract Doc Link 11720889 Disease Relevance 0.27 Pain Relevance 0.12
In addition, the expression of 5alpha-reductase Type I mRNA and protein was lower in socially-isolated mice than that in group-housed mice whereas 3alpha-HSD mRNA expression remained unchanged.
Gene_expression (expression) of 5alpha-reductase
4) Confidence 0.75 Published 2001 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 11744079 Disease Relevance 0.34 Pain Relevance 0.42
The RNA concentration was measured with a NanoDrop ND-100 spectrophotometer. qRT-PCR was performed to monitor the gene expression levels of 5-alpha reductase type 1 and p450-aromatase.
Gene_expression (expression) of 5-alpha reductase
5) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0 Pain Relevance 0.28
Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma

Background

Gene_expression (Expression) of SRD5A1 associated with breast cancer
6) Confidence 0.73 Published 2004 Journal BMC Cancer Section Title Doc Link PMC459223 Disease Relevance 0.32 Pain Relevance 0
R1 (SRD5A1) expression in tumor than in the normal tissue.
Gene_expression (expression) of SRD5A1 associated with cancer
7) Confidence 0.73 Published 2004 Journal BMC Cancer Section Body Doc Link PMC459223 Disease Relevance 0.50 Pain Relevance 0
AKR1C1 and SRD5A1 messenger RNA expression at term in the human myometrium and chorioamniotic membranes.
Gene_expression (expression) of SRD5A1 in myometrium
8) Confidence 0.67 Published 2008 Journal Am J Perinatol Section Title Doc Link 18770491 Disease Relevance 0.07 Pain Relevance 0.07
Based on these observations, we can assume that HLDF-6 peptide displays at least two effects on androgen hormones metabolism in males: it stimulates testosterone biosynthesis by both testes and adrenals and simultaneously inhibits its conversion to dihydrotestosterone (DHT), most probably by diminution of 5alpha-reductase isoform 1 mRNA expression.
Gene_expression (expression) of 5alpha-reductase in testes
9) Confidence 0.65 Published 2005 Journal Regul. Pept. Section Abstract Doc Link 15680477 Disease Relevance 0.23 Pain Relevance 0.10
The presence of the steroidogenic enzymes cytochrome P450(SCC), aromatase, 5alpha-reductase, 3alpha-hydroxysteroid dehydrogenase, and 17beta-hydroxysteroid dehydrogenase in the human brain has now been firmly established by molecular biological and biochemical studies.
Gene_expression (presence) of 5alpha-reductase in brain
10) Confidence 0.65 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 14993041 Disease Relevance 0 Pain Relevance 0.10
In this experiment we study the mRNA expression of 5-alpha reductase type 1 (5aR-1) and p450-aromatase (AROM).
Gene_expression (expression) of 5-alpha reductase
11) Confidence 0.65 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0.21 Pain Relevance 0.44
The results provide the first evidence that expression levels of SRD5A1/2 are elevated whereas those of AKR1-3 are markedly decreased in breast carcinoma.
Gene_expression (expression) of SRD5A1 associated with breast cancer
12) Confidence 0.64 Published 2004 Journal BMC Cancer Section Body Doc Link PMC459223 Disease Relevance 0.65 Pain Relevance 0
Quantitative real-time reverse-transcriptase polymerase chain reaction was used to compare relative mRNA expression of AKR1C1 and SRD5A1 in the myometrium and chorioamniotic membranes from 20 subjects during three different states of labor: not in labor ( N = 10), spontaneous labor ( N = 5), or induced labor ( N = 5).
Gene_expression (expression) of SRD5A1 in myometrium
13) Confidence 0.60 Published 2008 Journal Am J Perinatol Section Abstract Doc Link 18770491 Disease Relevance 0.08 Pain Relevance 0.08
Aromatase and 5-alpha reductase gene expression: modulation by pain and morphine treatment in male rats

Background

Gene_expression (expression) of 5-alpha reductase associated with pain and morphine
14) Confidence 0.58 Published 2010 Journal Mol Pain Section Title Doc Link PMC2978140 Disease Relevance 0.19 Pain Relevance 0.95
We showed upregulation of AROM activity in astrocytes in vitro[6] and Amini et al. [7] demonstrated an increase of 5-alpha reductase expression in vivo.
Gene_expression (expression) of 5-alpha reductase in astrocytes
15) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0.22 Pain Relevance 0.49
The main result of the present experiment is that the expression of 5-alpha reductase type 1 (5aR-1) and p450-aromatase (AROM) in the male rat brain, liver and testis was strongly affected by inflammatory pain and morphine.
Gene_expression (expression) of 5-alpha reductase in testis associated with ipn and morphine
16) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0.25 Pain Relevance 0.65
The purpose of this study on male rats was to determine the effects of a single injection of morphine (5 mg/Kg) on persistent pain (formalin test) and the single or combined effects on p450-aromatase and 5-alpha reductase type 1 mRNA expression in the brain, liver and testis.
Gene_expression (expression) of 5-alpha reductase in testis associated with pain, lasting pain and morphine
17) Confidence 0.58 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2978140 Disease Relevance 0.17 Pain Relevance 0.95
The alpha 2 delta-1, alpha 2 delta-2, and alpha 2 delta-3 subunits of voltage-gated Ca(2+) channels, presumed sites of gabapentin and pregabalin action, were detected with immunoblots of human neocortical synaptosomes.
Gene_expression (detected) of alpha 2 delta-1 associated with pregabalin and gabapentin
18) Confidence 0.25 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 11804619 Disease Relevance 0 Pain Relevance 1.20
Overall, the authors conclude that combination of testosterone and staged surgery resulted in pleasing appearance of external genitalia in most patients and recommended MGP for androgen-responsive patients with 17-hydrogenase deficiency.Mendonca et al. [46] reported a cohort of 46, XY patients with 5 alpha-reductase deficiency in Brazil; 14 of 25 patients registered as the female social sex changed to a male gender role around the time of puberty.
Gene_expression (deficiency) of 5 alpha-reductase in genitalia
19) Confidence 0.24 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2963131 Disease Relevance 0.51 Pain Relevance 0
The main result of the present experiment is that the expression of 5-alpha reductase type 1 (5aR-1) and p450-aromatase (AROM) in the male rat brain, liver and testis was strongly affected by inflammatory pain and morphine.
Gene_expression (expression) of 5-alpha reductase in brain associated with ipn and morphine
20) Confidence 0.20 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0.25 Pain Relevance 0.65

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