INT99504

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Context Info
Confidence 0.56
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 8.89
Pain Relevance 4.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Anatomy Link Frequency
neuronal 2
primary neurons 1
neurons 1
spinal cord 1
heart 1
Bax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 60 99.78 Very High Very High Very High
Morphine 24 99.78 Very High Very High Very High
Kinase C 1 99.72 Very High Very High Very High
Spinal cord 5 99.42 Very High Very High Very High
dopamine receptor 4 98.72 Very High Very High Very High
ketamine 18 97.88 Very High Very High Very High
Glutamate 151 97.76 Very High Very High Very High
gABA 6 97.48 Very High Very High Very High
Neuropeptide 1 95.20 Very High Very High Very High
spinothalamic tract 5 93.56 High High
Disease Link Frequency Relevance Heat
Apoptosis 380 99.76 Very High Very High Very High
Death 151 99.68 Very High Very High Very High
Spinal Cord Injury 2 99.42 Very High Very High Very High
Contusions 4 99.08 Very High Very High Very High
Injury 74 98.92 Very High Very High Very High
Cancer 24 98.62 Very High Very High Very High
Hypoxia 62 98.50 Very High Very High Very High
Anaplastic Astrocytoma 4 97.74 Very High Very High Very High
Cv Unclassified Under Development 61 92.48 High High
Retina Disease 34 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine treatment decreases Bax and Hsp70 levels in cultured rat primary neurons, suggesting morphine may have a protective role in staurosporine and serum deprivation induced cytotoxicity.
Negative_regulation (decreases) of Bax in primary neurons associated with morphine
1) Confidence 0.56 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18601975 Disease Relevance 0.44 Pain Relevance 0.87
Analyses 24 h post I/R revealed that Bax and Bcl-xL were downregulated (0.841±0.033, p<0.05, and 0.604±0.025, p<0.01, respectively) while Bak was upregulated (1.478±0.052, p<0.001; Figure 3A-B,D).
Negative_regulation (downregulated) of Bax
2) Confidence 0.48 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0 Pain Relevance 0
Apoptosis in the injured spinal cord correlated well with prompt decreases in Bcl-xL protein levels and Bcl-xL/Bax protein ratios at the contusion site.
Negative_regulation (decreases) of Bax in spinal cord associated with spinal cord injury, contusions, apoptosis and spinal cord
3) Confidence 0.42 Published 2001 Journal J. Neurotrauma Section Abstract Doc Link 11721745 Disease Relevance 1.21 Pain Relevance 0.65
These authors showed that in 1321N1 astrocytoma cells expressing P2Y2 receptors, acute treatment with UTP upregulated anti-apoptotic genes Bcl-2 and Bcl-Xl and downregulated the proapoptotic gene Bax.
Negative_regulation (downregulated) of Bax in 1321N1 associated with anaplastic astrocytoma and apoptosis
4) Confidence 0.42 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096663 Disease Relevance 0.33 Pain Relevance 0.05
We and others have previously reported that glutamate induces characteristic oligonucleosomal DNA fragmentation (DNA ladder) and apoptotic cell death by up and down-regulation of Bax and Bcl-2, in a stable mouse hippocampal neuronal cell line HT22 which lacks caspase-3, the primary activator of apoptotic DNA fragmentation [5].
Negative_regulation (regulation) of Bax in neuronal associated with glutamate, apoptosis and death
5) Confidence 0.42 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1526740 Disease Relevance 0.83 Pain Relevance 0.25
Nonetheless, in street heroin-treated cortical neurons, cytochrome c was released, accompanied by a decrease in mitochondrial potential and Bcl-2/Bax.
Negative_regulation (decrease) of Bax in neurons
6) Confidence 0.42 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17250679 Disease Relevance 0.56 Pain Relevance 0.15
Accordingly, the ratio of bcl-2 to bax was reduced in the reperfused area, indicating a pro-apoptotic trend.
Negative_regulation (reduced) of bax associated with apoptosis
7) Confidence 0.41 Published 2001 Journal Jpn Heart J Section Abstract Doc Link 11933925 Disease Relevance 0.49 Pain Relevance 0.14
In the core, neuronal apoptotic inhibitory protein (NAIP), GABA-A alpha1 subunit, GRIN2C, GRIA1, mGluR1, D4 dopamine receptor and PSD-95 were upregulated by morphine administration whereas bax, bcl-x, cox-1 and MAP2 were decreased.
Negative_regulation (decreased) of bax in neuronal associated with gaba, dopamine receptor, apoptosis and morphine
8) Confidence 0.41 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183518 Disease Relevance 0.10 Pain Relevance 1.29
At the late phase of recovery, Bax and Bcl-xL mRNAs were downregulated while Bak was increased.
Negative_regulation (downregulated) of Bax
9) Confidence 0.36 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2765238 Disease Relevance 0.84 Pain Relevance 0.22
After EA, in comparison with model group 2, Fas and FasL IR-positive cell number and Bax/Bcl-2 decreased significantly (P < 0.01, 0.05), and Bcl-2 IR-positive cell number increased markedly in EA group (P < 0.05); in comparison with model group 1, Bcl-2 IR-positive cell number increased significantly (P < 0.01), while Bax, Fas and FasL IR-positive cell number and Bax/Bcl-2 decreased evidently in EA group (P < 0.01).
Negative_regulation (decreased) of Bax
10) Confidence 0.31 Published 2008 Journal Zhen Ci Yan Jiu Section Body Doc Link 18928115 Disease Relevance 0 Pain Relevance 0
In comparison with model group 2, Bcl-2 IR-positive cell number of model group 1 decreased significantly (P < 0.05), Bax, Fas and FasL IR-positive cell number and Bax/Bcl-2 of model group 1 were significantly higher (P < 0.01, fl. 05).
Negative_regulation (decreased) of Bax
11) Confidence 0.31 Published 2008 Journal Zhen Ci Yan Jiu Section Body Doc Link 18928115 Disease Relevance 0.05 Pain Relevance 0
As a result, the ratio of Bcl-2/Bax was significantly reduced.
Negative_regulation (reduced) of Bax
12) Confidence 0.27 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967004 Disease Relevance 0.11 Pain Relevance 0
Chronic treatment with Cl significantly reduced TUNEL positivity (p < 0.05), Bax protein (p < 0.001) and upregulated Bcl-2 (p < 0.001) expression in comparison to control IR group.
Negative_regulation (reduced) of Bax protein
13) Confidence 0.25 Published 2006 Journal BMC Complement Altern Med Section Abstract Doc Link PMC1397864 Disease Relevance 0.41 Pain Relevance 0.03
Thus a decrease in the BCL-XL/Bax ratio is associated with apoptosis as was seen with ketamine.
Negative_regulation (decrease) of Bax associated with ketamine and apoptosis
14) Confidence 0.24 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 0.53 Pain Relevance 0.31
Six months of acetaminophen treatment decreased Bax protein level by 53.8%, when compared to the age-matched control animals (P<0.05).
Negative_regulation (decreased) of Bax associated with paracetamol
15) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.14 Pain Relevance 0.40
In addition, activaton of Erk 1/2 inhibits the conformational change in Bax protein and cytochrome c-induced caspase activation, thereby preventing apoptosis.31 The anti-apoptotic protein Bcl-2 was identified in the outer mitochondrial membrane and attenuates cellular injury by inhibiting cytochrome c translocation, preventing injurious Ca2+ release from the endoplasmic reticulum32 and inhibiting Bax translocation from the cytoplasm to the mitochondria.33 During IPC, an increase in Bcl-2 concomitant with a decrease in the proapoptotic protein Bax was observed in the isolated rat heart.34 It has been reported that overexpression of Bax can affect the storage of Ca2+ in the intracellular membranes, and changes in intracellular Ca2+ storage can feed back to the translocation of Bax from cytosol to intracellular membranes.35 Our results demonstrated that the thiopental-induced protective effect against hypoxia-reoxygenation injury was associated with an increase in Bcl-2 expression, decrease in Bax, and attenuation of mitochondrial cytochrome c release, resulting in the reduction of caspase-3 activity.
Negative_regulation (decrease) of Bax in heart associated with hypoxia, injury and apoptosis
16) Confidence 0.17 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.67 Pain Relevance 0
Concomitantly, renoprotective [28] and neuroprotective [29] effects of EPO could be attributed to an upregulation of Bcl-2 and a downregulation of Bax.
Negative_regulation (downregulation) of Bax
17) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2592699 Disease Relevance 0.81 Pain Relevance 0
This normally causes inhibition of the ubiquitin-proteosome complex and release of proapoptotic factors.36 Direct binding of the propargylamine moiety, however, prevents downstream activation of proapoptotic factors,37–40 partially via activation of anti-apoptotic factors including Bcl-2 and protein kinase C, and also by downregulation of proapoptotic catalysts including FAS and Bax protein families.36
Negative_regulation (downregulation) of Bax associated with kinase c and apoptosis
18) Confidence 0.10 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2695242 Disease Relevance 0.74 Pain Relevance 0.08
For example, previous research in our laboratory demonstrated that ethanol concentrations equal to those used in this study induced apoptosis in more differentiated postnatal cortical [10], and cerebellar explant cultures [11], perhaps because tumor-suppressor genes like p53, and down-stream pro-apoptotic genes like Bax are suppressed in proliferating cortical cells and only induced during differentiation [54].
Negative_regulation (suppressed) of Bax associated with cancer and apoptosis
19) Confidence 0.07 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.62 Pain Relevance 0

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