INT99505

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Context Info
Confidence 0.77
First Reported 2001
Last Reported 2010
Negated 0
Speculated 4
Reported most in Abstract
Documents 42
Total Number 48
Disease Relevance 33.12
Pain Relevance 10.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2l1) intracellular (Bcl2l1) response to stress (Bcl2l1)
cytoplasm (Bcl2l1) cytosol (Bcl2l1) cell proliferation (Bcl2l1)
Anatomy Link Frequency
retinas 3
brain 3
neurons 3
spinal cord 2
hippocampus 2
Bcl2l1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 11 100.00 Very High Very High Very High
Neuritis 2 99.92 Very High Very High Very High
Paracetamol 12 99.78 Very High Very High Very High
Hippocampus 19 99.68 Very High Very High Very High
dexamethasone 301 99.64 Very High Very High Very High
fluoxetine 22 99.62 Very High Very High Very High
spinothalamic tract 10 99.24 Very High Very High Very High
Spinal cord 22 98.88 Very High Very High Very High
ischemia 461 98.80 Very High Very High Very High
Nerve growth factor 4 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 1498 100.00 Very High Very High Very High
Shock 1 100.00 Very High Very High Very High
Optic Neuritis 2 99.92 Very High Very High Very High
B-cell Lymphoma 2 99.92 Very High Very High Very High
Contusions 8 99.72 Very High Very High Very High
Death 290 99.64 Very High Very High Very High
Convulsion 10 99.54 Very High Very High Very High
Breast Cancer 10 99.24 Very High Very High Very High
Injury 289 98.80 Very High Very High Very High
Retina Disease 171 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bcl-xL expression after contusion to the rat spinal cord.
Gene_expression (expression) of Bcl-xL in spinal cord associated with pain, contusions and spinal cord
1) Confidence 0.77 Published 2001 Journal J. Neurotrauma Section Title Doc Link 11721745 Disease Relevance 1.25 Pain Relevance 0.94
Active caspase-3 and Bax expressions were increased, whereas antiapoptotic Bcl-xl and heat shock protein (HSP) 27 expressions in DRGs were increased.
Gene_expression (expressions) of Bcl-xl associated with shock
2) Confidence 0.75 Published 2005 Journal Diabetes Section Abstract Doc Link 16249457 Disease Relevance 1.39 Pain Relevance 0.60
An early (2-3 days post-CCI) E2F1- and p53-independent apoptosis appeared in the spinal cord as the pro-apoptotic bax gene increased (320 +/- 19%), followed by an increased expression of the anti-apoptotic bcl-2 and bcl-xL genes (60 +/- 11% and 110 +/- 15%, respectively) 7 days from CCI.
Gene_expression (expression) of bcl-xL in spinal cord associated with injury, apoptosis and spinal cord
3) Confidence 0.75 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975670 Disease Relevance 1.77 Pain Relevance 0.85
Reboxetine, tranylcypromine, and ECS selectively increased Bcl-xl, but not Bcl-2 mRNA expression in the hippocampus.
Gene_expression (expression) of Bcl-xl in hippocampus associated with convulsion and hippocampus
4) Confidence 0.68 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17700647 Disease Relevance 1.04 Pain Relevance 0.67
Transduction of Bcl-XL in our study led to significant rescue of RGCs indicating the relevance of this pathway for neuronal survival under autoimmune inflammatory conditions.
Gene_expression (Transduction) of Bcl-XL in RGCs associated with inflammation
5) Confidence 0.65 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 16242630 Disease Relevance 1.22 Pain Relevance 0.33
We also showed SCI-associated changes in the expression of the antiapoptotic protein Bcl-xL, especially among STT cells, consistent with the hypothesis that Bcl-xL regulates the extent of apoptosis after SCI.
Gene_expression (expression) of Bcl-xL associated with spinothalamic tract and apoptosis
6) Confidence 0.60 Published 2001 Journal J. Neurotrauma Section Abstract Doc Link 11721745 Disease Relevance 1.27 Pain Relevance 0.68
Apoptosis related events such as p-ERK, p-Bad, Bcl-xl and cytochrome c expression were evaluated by Western blot analysis and myocardial caspase-3 activity was also measured.
Gene_expression (expression) of Bcl-xl associated with apoptosis
7) Confidence 0.57 Published 2008 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 18641058 Disease Relevance 0.69 Pain Relevance 0.15
However, our results showing a time-related decrease in Bcl-xL expression in the retina following I/R are in conflict with a publication on hippocampal neurons, where no alteration of the abundance of Bcl-xL was observed following I/R [27].
Gene_expression (expression) of Bcl-xL in neurons
8) Confidence 0.54 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.47 Pain Relevance 0.05
It clearly finds an association with an increase in Bax with a decrease in Bcl-xL expression and negates any involvement of Bak and Bcl-2 regulations in the damage induced by retinal ischemia 24 h after reperfusion.
Gene_expression (expression) of Bcl-xL associated with ischemia and retina disease
9) Confidence 0.54 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.71 Pain Relevance 0.17
The observation that Bcl-xL is the predominant Bcl-2 family member expressed in the retina supports the concept that the neural retina has a pattern of Bcl-2 expression similar to that of other central neurons [25,26].
Gene_expression (expressed) of Bcl-xL in neurons
10) Confidence 0.54 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.33 Pain Relevance 0.04
The up-regulated expression of Bcl-2, Bcl-xL and the cellular FLICE-inhibitory protein (c-FLIP) in fluoxetine-treated NSCs was detected by real-time RT-PCR.
Gene_expression (expression) of Bcl-xL in NSCs associated with fluoxetine
11) Confidence 0.50 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16545775 Disease Relevance 0.25 Pain Relevance 0.95
Taken together, we concluded that magnolol inhibits apoptosis through enhancing the activation of ERK1/2 and modulation of the Bcl-xl proteins which brings about reduction of infarct size and improvement of cardiac function in I/R-induced injury.
Gene_expression (modulation) of Bcl-xl associated with injury and apoptosis
12) Confidence 0.49 Published 2008 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 18641058 Disease Relevance 0.65 Pain Relevance 0.04
This suggests that modification in Bcl-xL expression after I/R in the retina could be identical to that following cerebral ischemia.
Gene_expression (expression) of Bcl-xL in retina associated with cv general 4 under development and ischemia
13) Confidence 0.47 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.45 Pain Relevance 0.05
As for mRNA, the Bax:Bcl-2 and Bax:Bcl-xL protein ratios did not reveal any modulation (1.144±0.238 and 0.970±0.129, respectively; Figure 2E-F).


Gene_expression (ratios) of Bcl-xL
14) Confidence 0.47 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0 Pain Relevance 0.06
Although slight differences between mRNA and protein regulation were obtained in ischemic and control retinas, Bax:Bcl-2 and Bax:Bcl-xL ratios were similarly modulated over time.
Gene_expression (ratios) of Bcl-xL in retinas
15) Confidence 0.47 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.60 Pain Relevance 0.26
The observation that neither the Bax:Bcl-2 nor the Bax:Bcl-xL ratios are regulated at a time when apoptosis is already detectable (3 h) suggests that Bcl-2-related family members are not associated with early cell death following I/R.
Gene_expression (ratios) of Bcl-xL associated with apoptosis and death
16) Confidence 0.47 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.56 Pain Relevance 0.07
The strong decline of Bcl-xL was further amplified in the Bax:Bcl-xL ratio (1.446±0.106; p<0.005; Figure 3F) Bcl-2 was not significantly modulated (0.759±0.116), nor was the Bax:Bcl-2 ratio (1.194±0.132, Figure 3C,E).


Gene_expression (ratio) of Bcl-xL
17) Confidence 0.47 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.06 Pain Relevance 0
Fluoxetine did not influence Bcl-xl expression in the hippocampus, but it was the only ADT that decreased Bax expression in this region.
Gene_expression (expression) of Bcl-xl in hippocampus associated with hippocampus and fluoxetine
18) Confidence 0.46 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17700647 Disease Relevance 0.97 Pain Relevance 0.66
Expression of apoptosis-related molecules, such as Bcl-xS, Bax, and caspase-3, seems to be little regulated in the early stage of this vessel remodeling process.


Gene_expression (Expression) of Bcl-xS associated with apoptosis
19) Confidence 0.45 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC119850 Disease Relevance 0.73 Pain Relevance 0
In addition, mefenamic acid up-regulates expression of the antiapoptotic protein Bcl-X(L).
Gene_expression (expression) of Bcl-X
20) Confidence 0.43 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16223958 Disease Relevance 0.90 Pain Relevance 0.54

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