INT99506

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Context Info
Confidence 0.58
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 15.70
Pain Relevance 6.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2l1) intracellular (Bcl2l1) response to stress (Bcl2l1)
cytoplasm (Bcl2l1) cytosol (Bcl2l1) cell proliferation (Bcl2l1)
Anatomy Link Frequency
neurons 2
spinal cord 2
neuronal 1
fibroblasts 1
hippocampus 1
Bcl2l1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 38 99.84 Very High Very High Very High
Spinal cord 16 99.42 Very High Very High Very High
Morphine 9 99.42 Very High Very High Very High
Hippocampus 7 99.24 Very High Very High Very High
Clonidine 2 99.22 Very High Very High Very High
dopamine receptor 2 98.62 Very High Very High Very High
amygdala 5 98.16 Very High Very High Very High
ketamine 41 97.72 Very High Very High Very High
gABA 5 97.38 Very High Very High Very High
spinothalamic tract 10 93.56 High High
Disease Link Frequency Relevance Heat
Apoptosis 550 100.00 Very High Very High Very High
Injury 122 99.82 Very High Very High Very High
Spinal Cord Injury 4 99.42 Very High Very High Very High
Death 157 99.00 Very High Very High Very High
Contusions 8 98.92 Very High Very High Very High
Middle Cerebral Artery Infarction 18 98.80 Very High Very High Very High
Stroke 42 96.04 Very High Very High Very High
Fistula 21 96.04 Very High Very High Very High
Stress 183 95.36 Very High Very High Very High
Cancer 41 94.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apoptosis in the injured spinal cord correlated well with prompt decreases in Bcl-xL protein levels and Bcl-xL/Bax protein ratios at the contusion site.
Negative_regulation (decreases) of Bcl-xL in spinal cord associated with spinal cord injury, contusions, apoptosis and spinal cord
1) Confidence 0.58 Published 2001 Journal J. Neurotrauma Section Abstract Doc Link 11721745 Disease Relevance 1.21 Pain Relevance 0.65
Apoptosis in the injured spinal cord correlated well with prompt decreases in Bcl-xL protein levels and Bcl-xL/Bax protein ratios at the contusion site.
Negative_regulation (decreases) of Bcl-xL in spinal cord associated with spinal cord injury, contusions, apoptosis and spinal cord
2) Confidence 0.58 Published 2001 Journal J. Neurotrauma Section Abstract Doc Link 11721745 Disease Relevance 1.21 Pain Relevance 0.65
Bcl-xl mRNA was significantly decreased in hippocampal subfields.
Negative_regulation (decreased) of Bcl-xl mRNA
3) Confidence 0.51 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17700647 Disease Relevance 0.97 Pain Relevance 0.56
Administration of clonidine 20 min after yohimbine administration abolished its effect on Bcl-XL mRNA level in the hippocampus.
Negative_regulation (abolished) of Bcl-XL in hippocampus associated with hippocampus and clonidine
4) Confidence 0.43 Published 2008 Journal Izv. Akad. Nauk. Ser. Biol. Section Abstract Doc Link 18491567 Disease Relevance 0.07 Pain Relevance 0.45
Melatonin-induced neuroprotection was mediated, at least in part, via the inhibition of mitochondria-dependent apoptotic pathway since melatonin caused an up-regulation of the anti-apoptotic protein, bcl-X(L), reduction in anesthesia-induced cytochrome c release into the cytoplasm and a decrease in anesthesia-induced activation of caspase-3, an important step in the activation of DNAses and the formation of the apoptotic bodies.
Negative_regulation (reduction) of bcl-X associated with anesthesia and apoptosis
5) Confidence 0.42 Published 2006 Journal Neurobiol. Dis. Section Abstract Doc Link 16289675 Disease Relevance 0.63 Pain Relevance 0.67
In the core, neuronal apoptotic inhibitory protein (NAIP), GABA-A alpha1 subunit, GRIN2C, GRIA1, mGluR1, D4 dopamine receptor and PSD-95 were upregulated by morphine administration whereas bax, bcl-x, cox-1 and MAP2 were decreased.
Negative_regulation (decreased) of bcl-x in neuronal associated with gaba, dopamine receptor, apoptosis and morphine
6) Confidence 0.41 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183518 Disease Relevance 0.10 Pain Relevance 1.29
We found that the intrinsic pathway is activated early on during anesthesia exposure (within two hours), as measured by the down-regulation of bcl-x(L), up-regulation of cytochrome c and the activation of caspase-9 in 7-day-old rats (the peak of synaptogenesis), but remains inactivated in 14-day-old rats (the end of synaptogenesis).
Negative_regulation (down-regulation) of bcl-x associated with anesthesia
7) Confidence 0.41 Published 2005 Journal Neuroscience Section Abstract Doc Link 16154281 Disease Relevance 0.57 Pain Relevance 0.32
The injury is mostly due to Bcl-xL downregulation rather than downregulation in Bcl-2 expression.
Negative_regulation (downregulation) of Bcl-xL associated with injury
8) Confidence 0.41 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.62 Pain Relevance 0.22
Consistent with mRNA and protein regulation was the time-dependent downregulation of Bcl-xL.
Negative_regulation (downregulation) of Bcl-xL
9) Confidence 0.41 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.34 Pain Relevance 0.03
Analyses 24 h post I/R revealed that Bax and Bcl-xL were downregulated (0.841±0.033, p<0.05, and 0.604±0.025, p<0.01, respectively) while Bak was upregulated (1.478±0.052, p<0.001; Figure 3A-B,D).
Negative_regulation (downregulated) of Bcl-xL
10) Confidence 0.41 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0 Pain Relevance 0
The strong decline of Bcl-xL was further amplified in the Bax:Bcl-xL ratio (1.446±0.106; p<0.005; Figure 3F) Bcl-2 was not significantly modulated (0.759±0.116), nor was the Bax:Bcl-2 ratio (1.194±0.132, Figure 3C,E).


Negative_regulation (decline) of Bcl-xL
11) Confidence 0.36 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.05 Pain Relevance 0
At the late phase of recovery, Bax and Bcl-xL mRNAs were downregulated while Bak was increased.
Negative_regulation (downregulated) of Bcl-xL
12) Confidence 0.30 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2765238 Disease Relevance 0.84 Pain Relevance 0.22
Three hours after I/R, the following proapoptotic Bax (0.679±0.058, p<0.05) and Bak mRNAs (0.600±0.033, p<0.001), as well as the antiapoptotic Bcl-xL (0.768±0.047, p<0.05) were significantly downregulated.
Negative_regulation (downregulated) of Bcl-xL
13) Confidence 0.30 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.15 Pain Relevance 0.12
Bax expression significantly increased by about 30% both at the mRNA (1.325±0.044) and protein levels (1.383±0.135), while Bcl-xL decreased by about 20% at the mRNA (0.787±0.033) and protein levels (0.826±0.106).
Negative_regulation (decreased) of Bcl-xL
14) Confidence 0.30 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.21 Pain Relevance 0.03
The sustained increase in GFAP indicates astrogliosis, while the decreased bcl-xl protein level suggests a commitment to cellular death, as clearly shown by the reduction in the RGC population and decreased thy-1 expression.
Negative_regulation (decreased) of bcl-xl associated with death
15) Confidence 0.26 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2831780 Disease Relevance 0.41 Pain Relevance 0
GFAP (a marker of astrogliosis) remained upregulated at days 2, 7, and 14, while bcl-xl (anti-apoptotic) decreased.


Negative_regulation (decreased) of bcl-xl associated with apoptosis
16) Confidence 0.26 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2831780 Disease Relevance 0.47 Pain Relevance 0
For example, the mRNA levels of Bcl-xS were initially decreased at 1 day, 3 days and 1 week followed by returning to base line level after 2 weeks.
Negative_regulation (decreased) of Bcl-xS
17) Confidence 0.25 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC119850 Disease Relevance 0.64 Pain Relevance 0.06
Bcl-xl downregulation is involved in initiating apoptosis and not surprisingly was reduced following ONC (Figure 5B, 67±9% and 56±10% at days 7 and 14, respectively, p<0.005, n=7).
Negative_regulation (downregulation) of Bcl-xl associated with apoptosis
18) Confidence 0.23 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.63 Pain Relevance 0
It has been reported that CNTF, Bcl-xL and Caspase inhibitor could increase the survival of rat vasopressin magnocellular neurons in organotypic cluture.
Negative_regulation (inhibitor) of Bcl-xL in neurons
19) Confidence 0.18 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2442085 Disease Relevance 0.84 Pain Relevance 0
We observed that NaAsO2 induced up-regulation of pro apoptotic (active non-phospho form of Bad, Bax) and down-regulation of anti apoptotic (active non-phospho form of Bcl-2, Bcl-xL) Bcl-2 family proteins both in vivo and in vitro (Fig. 5A, 5B, 5C, 5D).
Negative_regulation (regulation) of Bcl-xL associated with apoptosis
20) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.89 Pain Relevance 0

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