INT99507

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 9.23
Pain Relevance 4.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2l1) intracellular (Bcl2l1) response to stress (Bcl2l1)
cytoplasm (Bcl2l1) cytosol (Bcl2l1) cell proliferation (Bcl2l1)
Anatomy Link Frequency
hippocampus 2
spinal 1
brain 1
1321N1 1
cortex 1
Bcl2l1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 11 99.88 Very High Very High Very High
anesthesia 32 99.28 Very High Very High Very High
amygdala 5 97.96 Very High Very High Very High
Pain 9 97.64 Very High Very High Very High
ischemia 144 96.64 Very High Very High Very High
Immobilon 2 95.40 Very High Very High Very High
Thalamus 2 94.12 High High
Spinal cord 8 93.56 High High
cerebral cortex 2 93.24 High High
fluoxetine 2 93.00 High High
Disease Link Frequency Relevance Heat
Apoptosis 283 100.00 Very High Very High Very High
Convulsion 4 99.74 Very High Very High Very High
Injury 46 99.48 Very High Very High Very High
Anaplastic Astrocytoma 4 98.82 Very High Very High Very High
Spinal Injuries 1 98.36 Very High Very High Very High
Contusions 4 97.96 Very High Very High Very High
Pain 8 97.64 Very High Very High Very High
Retina Disease 68 96.64 Very High Very High Very High
Spinal Cord Injury 2 93.56 High High
Cv Unclassified Under Development 55 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Yohimbine decreased Bax mRNA level in the cerebellum, increased the ratio between Bcl-XL and Bax mRNA levels in the cerebellum, cortex, and hippocampus, and increased Bcl-XL mRNA level in the cortex and hippocampus of 6-day-old-rat pups 24 h after injection.
Positive_regulation (increased) of Bcl-XL in cerebellum associated with hippocampus
1) Confidence 0.69 Published 2008 Journal Izv. Akad. Nauk. Ser. Biol. Section Abstract Doc Link 18491567 Disease Relevance 0.07 Pain Relevance 0.45
Melatonin-induced neuroprotection was mediated, at least in part, via the inhibition of mitochondria-dependent apoptotic pathway since melatonin caused an up-regulation of the anti-apoptotic protein, bcl-X(L), reduction in anesthesia-induced cytochrome c release into the cytoplasm and a decrease in anesthesia-induced activation of caspase-3, an important step in the activation of DNAses and the formation of the apoptotic bodies.
Positive_regulation (up-regulation) of bcl-X associated with anesthesia and apoptosis
2) Confidence 0.67 Published 2006 Journal Neurobiol. Dis. Section Abstract Doc Link 16289675 Disease Relevance 0.64 Pain Relevance 0.68
We interpret these results as evidence that regulation of Bcl-xL may play a role in neural sparing after spinal injury and pain-signaling function.
Positive_regulation (regulation) of Bcl-xL in spinal associated with pain and spinal injuries
3) Confidence 0.50 Published 2001 Journal J. Neurotrauma Section Abstract Doc Link 11721745 Disease Relevance 1.34 Pain Relevance 0.63
Contrary to mRNA, Bax and Bcl-xL protein levels were significantly upregulated 24 h post I/R (1.511±0.148 and 1.402±0.188, p<0.05, respectively).
Positive_regulation (upregulated) of Bcl-xL
4) Confidence 0.49 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.08 Pain Relevance 0
Melatonin-induced neuroprotection was mediated, at least in part, via the inhibition of mitochondria-dependent apoptotic pathway since melatonin caused an up-regulation of the anti-apoptotic protein, bcl-X(L), reduction in anesthesia-induced cytochrome c release into the cytoplasm and a decrease in anesthesia-induced activation of caspase-3, an important step in the activation of DNAses and the formation of the apoptotic bodies.
Positive_regulation (caused) of bcl-X associated with anesthesia and apoptosis
5) Confidence 0.48 Published 2006 Journal Neurobiol. Dis. Section Abstract Doc Link 16289675 Disease Relevance 0.64 Pain Relevance 0.68
Reboxetine, tranylcypromine, and ECS selectively increased Bcl-xl, but not Bcl-2 mRNA expression in the hippocampus.
Neg (not) Positive_regulation (increased) of Bcl-xl in hippocampus associated with convulsion and hippocampus
6) Confidence 0.44 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17700647 Disease Relevance 1.03 Pain Relevance 0.66
The mRNA expression levels of the bcl-2 genes family was changed as follows: bax increased up to 40% in CCI vs the sham rats, while bcl-2 did not change; bcl-xS massively decreased (by 70% and 100%), while bcl-xL increased (by 40%) in CCI rats.
Positive_regulation (increased) of bcl-xL associated with injury
7) Confidence 0.37 Published 2002 Journal Neuroreport Section Abstract Doc Link 11924868 Disease Relevance 1.09 Pain Relevance 0.42
At the late phase of recovery, Bax and Bcl-xL mRNAs were downregulated while Bak was increased.
Positive_regulation (increased) of Bcl-xL
8) Confidence 0.33 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2765238 Disease Relevance 0.84 Pain Relevance 0.22
Analyses 24 h post I/R revealed that Bax and Bcl-xL were downregulated (0.841±0.033, p<0.05, and 0.604±0.025, p<0.01, respectively) while Bak was upregulated (1.478±0.052, p<0.001; Figure 3A-B,D).
Positive_regulation (upregulated) of Bcl-xL
9) Confidence 0.33 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0 Pain Relevance 0
At the protein level, proapoptotic Bax and Bak were not modulated while Bcl-2 and Bcl-xL were significantly upregulated.
Positive_regulation (upregulated) of Bcl-xL
10) Confidence 0.33 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2765238 Disease Relevance 0.88 Pain Relevance 0.24
Yohimbine decreased Bax mRNA level in the cerebellum, increased the ratio between Bcl-XL and Bax mRNA levels in the cerebellum, cortex, and hippocampus, and increased Bcl-XL mRNA level in the cortex and hippocampus of 6-day-old-rat pups 24 h after injection.
Positive_regulation (increased) of Bcl-XL in hippocampus associated with hippocampus
11) Confidence 0.23 Published 2008 Journal Izv. Akad. Nauk. Ser. Biol. Section Abstract Doc Link 18491567 Disease Relevance 0.07 Pain Relevance 0.45
Yohimbine decreased Bax mRNA level in the cerebellum, increased the ratio between Bcl-XL and Bax mRNA levels in the cerebellum, cortex, and hippocampus, and increased Bcl-XL mRNA level in the cortex and hippocampus of 6-day-old-rat pups 24 h after injection.
Positive_regulation (increased) of Bcl-XL in cortex associated with hippocampus
12) Confidence 0.23 Published 2008 Journal Izv. Akad. Nauk. Ser. Biol. Section Abstract Doc Link 18491567 Disease Relevance 0.07 Pain Relevance 0.45
However, taurine treatment inhibited As-induced up-regulation of Bad, Bax and down-regulation of Bcl-2, Bcl-xL.
Positive_regulation (regulation) of Bcl-xL
13) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.76 Pain Relevance 0
As seen in figure 7, immunofluorescent staining performed in brain sections from animals after 24 hr of reperfusion showed that, in comparable regions, H-100-treated brain expressed higher levels of Bcl-xL than vehicle-treated brain.
Positive_regulation (levels) of Bcl-xL in brain
14) Confidence 0.16 Published 2010 Journal Journal of Neuroinflammation Section Body Doc Link PMC3022819 Disease Relevance 0.37 Pain Relevance 0
After blockade of non-specific binding sites, membranes were incubated for 2 h at room temperature with a mouse monoclonal anti-Bcl-xL (1:1,000; BD PharMingen, Heidelberg, Germany) or a mouse monoclonal anti-Bax antibody (1:250; BD PharMingen), followed by a secondary peroxidase-linked anti-mouse antibody (BcL-xL 1:10,000 and Bax 1:20,000; Sigma).
Positive_regulation (incubated) of BcL-xL
15) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2592699 Disease Relevance 0.16 Pain Relevance 0.05
In the present study we could observe an initial upregulation of the anti-apoptotic member Bcl-xL at 24 h after pHx in the EPO-treated group.
Positive_regulation (upregulation) of Bcl-xL associated with apoptosis
16) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2592699 Disease Relevance 0.85 Pain Relevance 0
These authors showed that in 1321N1 astrocytoma cells expressing P2Y2 receptors, acute treatment with UTP upregulated anti-apoptotic genes Bcl-2 and Bcl-Xl and downregulated the proapoptotic gene Bax.
Positive_regulation (upregulated) of Bcl-Xl in 1321N1 associated with anaplastic astrocytoma and apoptosis
17) Confidence 0.08 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096663 Disease Relevance 0.32 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox